Results 31 to 40 of about 2,051 (177)

CLEC4G Reverses Lenvatinib Resistance in Hepatocellular Carcinoma by Suppressing PD-1 Expression via the Wnt/<i>β</i>-Catenin Pathway. [PDF]

Int J Genomics
Objective The objective was to analyze the effect of C-type lectin domain family 4 member G (CLEC4G) on hepatocellular carcinoma (HCC) and investigate its impact on lenvatinib (Lenva) resistance as well as the underlying action pathway. Methods Differentially expressed genes (DEGs) were screened from the GSE101685 dataset, followed by functional ...
Xiao K, Yan J, He G, He B, Wang Q.
europepmc   +2 more sources

Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis. [PDF]

Journal of Infectious Diseases, 2012
Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases.A Nigerian cohort of 168 Schistosoma haematobium-infected individuals and 192 healthy controls were examined for functional single-nucleotide polymorphisms in the promoter region (-986G>A,
E. A. Ouf, O. Ojurongbe, A. Akindele, Olawumi R Sina-Agbaje, Hoang Van Tong, A. Adeyeba, P. Kremsner, J. Kun, T. Velavan   +8 more
semanticscholar   +4 more sources

Exosome-Mediated Lectin Pathway and Resistin-MIF-AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia. [PDF]

Adv Sci (Weinh)
Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Li J, Wang X, Chen Y, Sun X, Fu L, Xin Q, Zhang H, Qin B, Sun N, Li Y, Xu Y, Yang H, Huo D, Dong Y, Wang S, Zhao M, Lin Q, Wang F, Yue B, Gao Y, Jiang Y, Guo R.   +21 more
europepmc   +2 more sources

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2. [PDF]

Human Molecular Genetics, 2005
The ficolin 1, 2 and 3 (derived from the FCN1, 2 and 3 genes, respectively) are homologous soluble pattern recognition molecules of importance for innate immunity, comprising collagen-like and fibrinogen-like domains, binding to sugar groups on different types of microorganisms.
T. Hummelshøj, L. Munthe-Fog, H. Madsen, T. Fujita, M. Matsushita, P. Garred   +5 more
semanticscholar   +4 more sources

Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors

Frontiers in Immunology, 2021
Thousands of leprosy patients not only suffer from physical deformities, but also either have or have had hepatitis B virus (HBV) coinfection. Polymorphisms of the complement system modulate susceptibility to leprosy, but genetic susceptibility to past ...
Angelica Beate Winter Boldt, Angelica Beate Winter Boldt, Camila de Freitas Oliveira-Toré, Gabriela Canalli Kretzschmar, Hellen Weinschutz Mendes, Sérvio Túlio Stinghen, Fabiana Antunes Andrade, Valéria Bumiller-Bini, Letícia Boslooper Gonçalves, Anna Carolina de Moraes Braga, Ewalda von Rosen Seeling Stahlke, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Steffen Thiel, Iara José Taborda de Messias-Reason   +15 more
doaj   +1 more source

Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Proteomic evaluation of plasma samples could accelerate the identification of novel Alzheimer's disease (AD) biomarkers. We evaluated the novel NUcleic acid Linked Immuno‐Sandwich Assay (NULISA) proteomic method in an ethnically diverse cohort.
Zeng X, Sehrawat A, Lafferty TK, Chen Y, Rawat M, Kamboh MI, Villemagne VL, Lopez OL, Cohen AD, Karikari TK.   +9 more
europepmc   +2 more sources

Genetic Susceptibility to Rheumatic Heart Disease: A Narrative Literature Review Highlighting Evidence From African Populations and Research Gaps in Sudan. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Rheumatic heart disease (RHD) remains a significant public health burden in low‐ and middle‐income countries, particularly in sub‐Saharan Africa. Although socioeconomic factors contribute to disease persistence, genetic susceptibility plays a critical role in determining progression from Group A Streptococcal infection to ...
Alkhalifamohamed H, Jebreel WMA, Elhassan M, Ali SKM.   +3 more
europepmc   +2 more sources

Plasma Proteomic Biomarkers Relating to Alzheimer’s Disease: A Meta-Analysis Based on Our Own Studies

Frontiers in Aging Neuroscience, 2021
Background and Objective: Plasma biomarkers for the diagnosis and stratification of Alzheimer’s disease (AD) are intensively sought. However, no plasma markers are well established so far for AD diagnosis.
Liu Shi, Noel J. Buckley, Isabelle Bos, Isabelle Bos, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Kristel Sleegers, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lléo, Julius Popp, Julius Popp, Pablo Martinez-Lage, Cristina Legido-Quigley, Cristina Legido-Quigley, Frederik Barkhof, Frederik Barkhof, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Pieter Jelle Visser, Pieter Jelle Visser, Lars Bertram, Lars Bertram, Simon Lovestone, Simon Lovestone, Alejo J. Nevado-Holgado   +28 more
doaj   +1 more source

Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles [PDF]

, 2010
A naturally occurring nanoparticle, the plant virus Cowpea mosaic virus, can be decorated with ferrocene derivatives, of various linker lengths with amine and carboxylategroups, on the external surface using a range of conjugation strategies.
Alaa A. A. Aljabali, Astruc, Beasley, Chatterji, Chidsey, Constable, David J. Evans, Evans, Evans, Frederix, George P. Lomonossoff, Green, J. Elaine Barclay, Julea N. Butt, Lin, Lomonossoff, Lopez, Molina, Newkome, Padeste, Steinmetz, Steinmetz, Steinmetz, Togni, Wang, Wang, Wellink, Yang, Yang   +28 more
core   +1 more source

Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns

Frontiers in Immunology, 2023
IntroductionFicolin-2 is a serum pattern recognition molecule, involved in complement activation via the lectin pathway. This study aimed to investigate the association of ficolin-2 concentration in cord blood serum with complications related to ...
Gabriela Gajek, Anna S. Świerzko, Dariusz Jarych, Damian Mikulski, Paulina Kobiela, Karolina Chojnacka, Maja Kufelnicka-Babout, Agnieszka Szala-Poździej, Jędrzej Chrzanowski, Katarzyna Sobczuk, Wojciech Fendler, Misao Matsushita, Iwona Domżalska-Popadiuk, Jan Mazela, Jarosław Kalinka, Hideharu Sekine, Maciej Cedzyński   +16 more
doaj   +1 more source