Results 11 to 20 of about 2,051 (177)
Reliable and rapid characterization of functional
BMC Medical Genetics, 2012 Background Ficolin-2 coded by FCN2 gene is a soluble serum protein and an innate immune recognition element of the complement system. FCN2 gene polymorphisms reveal distinct geographical patterns and are documented to alter serum ficolin levels and ...
Ojurongbe Olusola +11 more
doaj +4 more sources
Cost-effective procedures for genotyping of human FCN2 gene single nucleotide polymorphisms [PDF]
Immunogenetics, 2013 L-ficolin (ficolin-2) is a complement-activating pattern-recognition lectin taking part in the innate immune response. Both its serum concentration and sugar binding capacity are influenced by single nucleotide polymorphisms (SNP) of the corresponding ...
Maciej Cedzynski
exaly +5 more sources
Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure [PDF]
ESC Heart FailureAims Most proteomic analyses in patients with heart failure (HF) focus on the stable ambulatory setting; pathways that drive acute decompensated heart failure (ADHF) are largely uncharacterized.
Kenneth T. Hubbell +8 more
doaj +3 more sources
Медицинская иммунологияAsthma is one of the most common chronic diseases in all age groups. Asthma has heterogeneous phenotypes with different etiologies. Many parameters are used to classify asthma, for example, the severity and level of flow control.
M. V. Smolnikova +3 more
doaj +3 more sources
The Impact of FCN2 Polymorphisms and Haplotypes on the Ficolin‐2 Serum Levels [PDF]
Scandinavian Journal of Immunology, 2007 AbstractFicolin‐2 (L‐ficolin), derived from the FCN2 gene, is an innate immunity pattern recognition molecule found in human serum in which inter‐individual variation in serum appears to be under genetic control. To validate and extend this finding, we developed a sandwich ELISA for detection of human Ficolin‐2 in serum samples and identified FCN2 ...
Hans O Madsen, Peter Garred
exaly +5 more sources
Definitions, 2020 This gene is involved in carbohydrate binding and the lectin complement pathway.
semanticscholar +2 more sources
Ficolin-2: A potential immune-related therapeutic target with low expression in liver cancer [PDF]
Frontiers in Oncology, 2022 ObjectiveThis study aimed to investigate the role of ficolin-2 (FCN2) in the development and course of hepatocellular carcinoma (HCC) and to contribute to the evolution of innovative HCC therapeutics.MethodsOncomine, GEPIA (Gene Expression Profiling ...
Li-ting Wang +6 more
doaj +2 more sources
International Journal of Rheumatology, 2022 Genetic association studies in rheumatoid arthritis conducted in various populations have yielded heterogeneous results. The present systematic review was conducted to synthesize the results of the studies in order to establish the impact of ...
S. Gil-Quiñones +5 more
semanticscholar +4 more sources
Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease [PDF]
Clinical and Experimental Immunology, 2009 Summary Ficolins are pattern-recognition proteins involved in innate immunity, which upon binding to their specific pathogen-associated molecular patterns on the microbial surfaces trigger the immune response either by binding to collectin cellular receptors or by initiating the complement lectin pathway.
Peter G Kremsner
exaly +4 more sources
Unveiling ficolins: diagnostic and prognostic biomarkers linked to the Tumor Microenvironment in Lung Cancer [PDF]
World Journal of Surgical OncologyBackground Ficolins (FCNs) are a family of proteins, comprising FCN1, FCN2 and FCN3, and integral to the immune system which have been implicated in the onset and progression of tumors.
Zeyu Zhang +6 more
doaj +2 more sources