Results 71 to 80 of about 6,140 (133)

Fc Proteoforms of ACPA IgG Discriminate Autoimmune Responses in Plasma and Synovial Fluid of Rheumatoid Arthritis Patients and Associate with Disease Activity

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Rheumatoid arthritis is a prototypic autoimmune disease characterized by highly prevalent autoantibodies – anti‐citrullinated protein antibodies (ACPA). A novel nanoHPLC‐MS approach based on the intact Fc/2 subunit identifies hitherto neglected Fc proteoform profiles of IgG (auto)antibodies across different biofluids. The findings demonstrate subclass‐
Constantin Blöchl, Eva Maria Stork, Hans Ulrich Scherer, Rene E. M. Toes, Manfred Wuhrer, Elena Domínguez‐Vega   +5 more
wiley   +1 more source

The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor

Nature Communications
Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw, Devra Huey, Makky Mousa-Makky, Jared Compaleo, Kylie Nennig, Aadit P. Shah, Fei Jiang, Xueer Qiu, Devon Klipsic, Raymond R. R. Rowland, Igor I. Slukvin, Meagan E. Sullender, Megan T. Baldridge, Haichang Li, Cody J. Warren, Adam L. Bailey   +15 more
doaj   +1 more source

The neonatal Fc receptor in cancer FcRn in cancer

Cancer Medicine, 2020
Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda, Guillaume Brachet, Caroline Goupille, Lobna Ouldamer, Valérie Gouilleux‐Gruart   +4 more
doaj   +1 more source

The Crystal Structure of Human IgD‐Fc Reveals Unexpected Differences With Other Antibody Isotypes

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 4, Page 786-800, April 2025.
ABSTRACT Of the five human antibody isotypes, the function of IgD is the least well‐understood, although various studies point to a role for IgD in mucosal immunity. IgD is also the least well structurally characterized isotype. Until recently, when crystal structures were reported for the IgD Fab, the only structural information available was a model ...
Anna M. Davies, Tam T. T. Bui, Raúl Pacheco‐Gómez, Susan K. Vester, Andrew J. Beavil, Hannah J. Gould, Brian J. Sutton, James M. McDonnell   +7 more
wiley   +1 more source

Pharmacokinetics‐Based Design of Subcutaneous Controlled Release Systems for Biologics

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 668-680, April 2025.
ABSTRACT Protein therapeutics have emerged as an exceedingly promising treatment modality in recent times but are predominantly given as intravenous administration. Transitioning to subcutaneous (SC) administration of these therapies could significantly enhance patient convenience by enabling at‐home administration, thereby potentially reducing the ...
Abigail K. Grosskopf, Antonio A. Ginart, Phillip Spinosa, Vittal Shivva   +3 more
wiley   +1 more source

Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension

Haematologica
Fusion of therapeutic proteins to the Fc fragment of human IgG1 promotes their FcRn-mediated recycling and subsequent extension in circulating half-life.
Alejandra Reyes-Ruiz, Sandrine Delignat, Aishwarya Sudam Bhale, Victoria Daventure, Robin V. Lacombe, Leslie Dourthe, Olivier Christophe, Sune Justesen, Krishnan Venkataraman, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes   +10 more
doaj   +1 more source

Antibody‐Nanoparticle Conjugates in Therapy: Combining the Best of Two Worlds

Small, Volume 21, Issue 15, April 16, 2025.
Antibody‐nanomaterial conjugates (ANCs) are an emerging therapeutic class combining the precise targeting specificity of antibodies with the versatility and functionality of nanomaterials. This review summarizes ANC design, synthesis, and potential therapeutic applications in this rapidly advancing field.
Aniruddha Adhikari, Irene A. Chen
wiley   +1 more source

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT: Pharmacometrics & Systems Pharmacology, 2019
Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms.
Hannah M. Jones, Zhiwei Zhang, Paul Jasper, Haobin Luo, Lindsay B. Avery, Lindsay E. King, Hendrik Neubert, Hugh A. Barton, Alison M. Betts, Robert Webster   +9 more
doaj   +1 more source

Skin Lesion Analysis Towards Melanoma Detection Using Deep Learning Network [PDF]

arXiv, 2017
Skin lesion is a severe disease in world-wide extent. Early detection of melanoma in dermoscopy images significantly increases the survival rate. However, the accurate recognition of melanoma is extremely challenging due to the following reasons, e.g.
arxiv  

Intravitreal Administration of Adalimumab‐Loaded Poly(Lactic‐co‐Glycolic Acid) Nanoparticles: Effects on Biodistribution and Pharmacokinetics

Small Science, Volume 5, Issue 4, April 2025.
Adalimumab‐loaded poly(lactic‐co‐glycolic acid) nanoparticles are developed to improve biodistribution and targeted delivery for inflammatory eye diseases. The system demonstrates favorable physicochemical properties, high encapsulation efficiency, sustained release, and minimal cytotoxicity.
Xurxo García‐Otero, Rubén Varela‐Fernández, Andrea Cuartero‐Martínez, Noemí Gómez‐Lado, Miguel González‐Barcia, Cristina Mondelo‐García, Carolina Feitosa, Pablo Aguiar, Anxo Fernández‐Ferreiro, Francisco J. Otero‐Espinar   +9 more
wiley   +1 more source