Results 101 to 110 of about 630,325 (166)

Patient Communication Outside of Visits: Implications for Remote Monitoring and Digital Care Models in Myasthenia Gravis

Muscle &Nerve, Volume 74, Issue S1, Page S118-S123, September 2026.
ABSTRACT Introduction/Aims Myasthenia gravis (MG) is a rare autoimmune disorder requiring individualized, specialized treatment, yet access to specialized care is limited and documentation fragmented. Several remote monitoring tools have emerged to address this gap, yet their integration into clinical care remains challenging.
Maike Stein, Lea Gerischer, Yvonne J. M. Campman, Anna Rostedt Punga, Pushpa Narayanaswami, Andreas Meisel, Martijn R. Tannemaat, Sophie Lehnerer   +7 more
wiley   +1 more source

Open-label study of efgartigimod in seronegative myasthenia gravis

Therapeutic Advances in Neurological Disorders
Background: The ADAPT trial demonstrated the benefit of efgartigimod, a neonatal Fc receptor (FcRn) inhibitor, in acetylcholine receptor antibody (AChRAb) positive patients with generalized myasthenia gravis (MG).
Mohamed Khateb, Ajith Sivadasan, Carolina Barnett-Tapia, Lubna Daniyal, Lahiru Fernando, Shiyi Chen, Leif Erik Lovblom, Hans Katzberg, Vera Bril   +8 more
doaj   +1 more source

Clinical outcomes, serum IgG changes, and follow-up observations in the treatment of anti-AChR antibody-positive generalized myasthenia gravis with Efgartigimod

BMC Neurology
Purpose To investigate the clinical effects, changes in serum IgG levels, and follow-up observations following treatment with Efgartigimod in patients with anti-acetylcholine receptor (anti-AChR) positive generalized myasthenia gravis (gMG). Methods This
Jingting Fu, Xianzhao Zheng, Xiaoli Ma, Qianqian Qu, Wenhao Cui, Xing Mao, Wenhua Fu, Haidong Lyv   +7 more
doaj   +1 more source

Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury

, 2019
The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG.
Mezo, Adam, Andersen, Jan Terje, Pyzik, Michal, Christianson, Greg, Lencer, Wayne, Rath, Timo, Gandhi, Amit, Kuo, Timothy, McDonnell, Kevin, Roopenian, Derry, Taylor, Zachary, Purohit, Shalaka, Mizoguchi, Atsushi, Blumberg, Richard, Kaplowitz, Neil, Hubbard, Jonathan, Nienaber, Vicki, Sandlie, Inger, Win, Sanda, Baker, Kristi, Jones, Susan, Blumberg, Laurence, Grenha, Rosa, Krämer, Thomas D.   +23 more
core   +1 more source

Beyond the tumour microenvironment: Harnessing border immunity for glioblastoma immunotherapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Lanjie Chen, Yixin Gao, Jian Zhong, Nu Zhang   +3 more
wiley   +1 more source

Pharmacokinetics and delivery of proteins modified with FcRn binding ligands [PDF]

, 2013
The importance of therapeutic recombinant proteins in medicine has led to a variety of tactics to increase their circulation time or to enable routes of administration other than injection. One clinically successful tactic to improve protein circulation
Sockolosky, Jonathan
core  

Myasthenia gravis: the future is here

The Journal of Clinical Investigation
Myasthenia gravis (MG) stands as a prototypical antibody-mediated autoimmune disease: it is dependent on T cells and characterized by the presence of autoantibodies targeting proteins located on the postsynaptic surface of skeletal muscle, known as the ...
Henry J. Kaminski, Patricia Sikorski, S. Isabel Coronel, Linda L. Kusner   +3 more
doaj   +1 more source

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles

Research into the neonatal Fc receptor (FcRn) has increased dramatically ever since Simister and Mostov first purified a rat version of the receptor.
George Haddad, Judith Blaine
core   +1 more source

The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]

Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
et al.,, Shaw, Teressa M, Sullender, Meagan E, Baldridge, Megan T   +3 more
core   +1 more source

Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation

IgGs have become successful drug scaffolds by combining specific target binding with the ability to induce cellular cytotoxicity. Furthermore, IgGs possess unusually long half-lives in the blood (2-3 weeks).
Alexander Leitner, Andersen, Jan Terje, Esben Trabjerg, Leitner, Alexander, Torleif Tollefsrud Gjølberg, Jan Terje Andersen, Gjolberg, Torleif Tollefsrud, Jeannette Nilsen, Trabjerg, Esben, Rand, Kasper D., Nilsen, Jeannette, Kasper D. Rand   +11 more
core   +1 more source