Results 91 to 100 of about 5,026 (198)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Povetacicept (ALPN-303; TACI vTD-Fc), an enhanced, potent dual inhibitor of BAFF and APRIL, ameliorates experimental autoimmune myasthenia gravis in C57BL/6N mice

Frontiers in Immunology
Background and ObjectivesMyasthenia gravis (MG) is a T cell-dependent, B cell-mediated autoimmune disease targeting the acetylcholine receptor (AChR) and other proteins of the neuromuscular junction postsynaptic membrane.
Elena Rinaldi, Elisa Puleo, Alessandra Consonni, Martina Miglietti, Renato Mantegazza, NingXin Wang, Stanford L. Peng, Katherine E. Lewis, Stacey R. Dillon, Fulvio Baggi   +9 more
doaj   +1 more source

Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation. [PDF]

, 2014
The TNF family ligand ectodysplasin A (EDA) regulates the induction, morphogenesis and/or maintenance of skin-derived structures such as teeth, hair, sweat glands and several other glands.
Kowalczyk-Quintas, C., Schneider, P.
core   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

Autoimmunization of Ewes Against Pregnancy-associated Glycoproteins Does Not Interfere with the Establishment and Maintenance of Pregnancy [PDF]

, 2009
doi:10.1017/S1751731109004145Pregnancy-associated glycoproteins (PAGs) are a large grouping of placental proteins that belong to the aspartic peptidase gene family.
Ealy, Alan D., Egen, Tina E., Green, Jonathan A., 1969-, Roberts, R. M. (Robert Michael), 1940-   +3 more
core   +1 more source

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, EarlyView.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source

Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection [PDF]

, 2019
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
Ballegeer, Marlies, Creytens, Sarah, De Vlieger, Dorien, Hengel, Hartmut, Hoffmann, Katja, Nerinckx, Wim, Remaut, Han, Saelens, Xavier, Schepens, Bert, Van Hoecke, Lien, Van Molle, Inge   +10 more
core   +2 more sources

Kidney Transplant Recipients Develop Nasal Mucosal Antibodies to SARS‐CoV‐2 With ACE2‐Inhibiting Activity Following mRNA Vaccination

Transplant Infectious Disease, EarlyView.
Kidney transplant recipients develop nasal mucosal antibodies after systemic COVID‐19 vaccination, which are able to inhibit binding of SARS‐CoV‐2 to the ACE2 receptor, but at a lower concentration than the general population. ABSTRACT Background Less than 60% of kidney transplant recipients (KTRs) become IgG seropositive for the viral spike (S ...
Vera J. C. H. Koomen, Christa E. van der Gaast‐deJongh, Fred van Opzeeland, Ria Philipsen, Marije C. Baas, A. Lianne Messchendorp, Frederike J. Bemelman, Marcia M. L. Kho, Carla C. Baan, Debbie van Baarle, Jan‐Stephan F. Sanders, Rob van Binnendijk, Gerco den Hartog, Ron T. Gansevoort, Renate G. van der Molen, Luuk B. Hilbrands, Dimitri A. Diavatopoulos   +16 more
wiley   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Emergency use of eculizumab in impending and manifest myasthenic crisis: a retrospective case series

Therapeutic Advances in Neurological Disorders
Impending and manifest myasthenic crisis (MC) represent life-threatening neurological emergencies that require immediate intervention. Although eculizumab, a terminal complement C5 inhibitor, has established efficacy in generalized myasthenia gravis ...
Ying Huang, Yihan Xiong, Hui Zhan, Futian Wu, Yichun Jiang, Yaqing Zhang, Jiaxun Chen, Silin Zeng, Ting Zhang, Xiaofeng Xiong, Zhuomin Chen, Fang Yang, Gang Li, Qianhui Xu   +13 more
doaj   +1 more source