Results 71 to 80 of about 630,325 (166)

Cell surface dynamics and cellular distribution of endogenous FcRn. [PDF]

, 2017
A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral pH.
Lena D'Hooghe, Sam Heywood, Paul Whitley, Andrew D Chalmers   +3 more
core   +1 more source

Successful treatment with efgartigimod as an add-on therapy for acute attack of anti-NMDA receptor encephalitis: a case report

BMC Neurology
Background Anti-NMDA receptor encephalitis is an autoimmune, antibody-mediated inflammatory disease of the brain characterized by the presence of IgG antibodies targeting the excitatory N-methyl-D-aspartate receptor (NMDAR).
Huasheng Huang, Yizhi Wei, Huihui Qin, Guangshun Han, Jie Li   +4 more
doaj   +1 more source

Efgartigimod-alfa therapy in acetylcholine receptor antibody myasthenia gravis: Romanian experience

Frontiers in Neurology
BackgroundEfgartigimod alfa, the first neonatal Fc receptor inhibitor approved for the treatment of acetylcholine receptor antibody (AChR)-positive generalized myasthenia gravis (MG), has demonstrated efficacy in randomized controlled trials.
Nicolae Grecu, Oana Antonia Mihalache, Eugenia Irene Davidescu, Eugenia Irene Davidescu, Rodica Bălașa, Rodica Bălașa, Mihaela Simu, Mihaela Simu, Mihaela Simu, Vitalie Văcăraș, Vitalie Văcăraș, Ileana-Maria Vodă, Andreea-Ioana Mușuroi, Andra Mădălina Ene, Diana Mihaela Petrescu, Cristina Elena Mitu, Lorena Furnică, Lorena Furnică, Amalia Cornea, Amalia Cornea, Romana Homorodean, Crisanda Vîlciu, Crisanda Vîlciu, Cristina Tiu, Cristina Tiu   +24 more
doaj   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Human IgE does not bind to human FcRn

, 2022
The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens.
Bentlage, Arthur E H, Ooijevaar-de Heer, Pleuni, Brinkhaus, Maximilian, Rispens, Theo, Derksen, Ninotska I L, van der Kooi, Elvera J, Vidarsson, Gestur   +6 more
core   +1 more source

Tumor intrinsic properties dictate Fc receptor expression and cancer cachexia associated increase in checkpoint inhibitor clearance

Frontiers in Immunology
PurposePatients with cancer cachexia display a general resistance to immune checkpoint inhibitor (ICI) therapy, and baseline ICI catabolic clearance is a predictive indicator for overall survival, independent of dose and drug exposure.
Bryan C. Remaily, Greg Young, Hannah Lathrop, Justin Thomas, Kyeongmin Kim, Trang T. Vu, Adeoluwa Adeluola, Camille Stanton, Gillian Mulcahy, Zhiliang Xie, Lauren Granchie, Yizhen Guo, Min Hai, Jessica Wedig, Maria Schmidt, Millennium Manna, Xiaokui Mo, Xiaokui Mo, Xiaokui Mo, Jeovanna Lowe, Jill A. Rafael-Fortney, Jill A. Rafael-Fortney, Edmund Folefac, Paul Gregorevic, Paul Gregorevic, Dwight H. Owen, Dwight H. Owen, Samuel K. Kulp, Latha P. Ganesan, Christopher C. Coss, Christopher C. Coss, Thomas A. Mace, Thomas A. Mace, Thomas A. Mace, Mitch A. Phelps, Mitch A. Phelps   +35 more
doaj   +1 more source

Sequential and Concurrent C5 and Neonatal Fc Receptor Inhibition in Prolonged Myasthenic Crisis due to Advanced Invasive Thymoma‐Associated Myasthenia Gravis: A Case Report and Literature Review

Clinical and Experimental Neuroimmunology, Volume 17, Issue 4, November 2026.
ABSTRACT Thymoma‐associated myasthenia gravis (TAMG) is frequently refractory, particularly when complicated by myasthenic crisis in advanced invasive disease. Complement C5 inhibitors and neonatal Fc receptor (FcRn) inhibitors have expanded the treatment of acetylcholine receptor (AChR) antibody‐positive generalized myasthenia gravis; however, their ...
Yuta Kizuka, Yuriko Nakamura, Kensuke Okada, Yu Okubo, Kaoru Kaseda, Hirofumi Toyama, Keisuke Asakura, Atsuya Takeda, Jin Nakahara, Kei Ishizuchi   +9 more
wiley   +1 more source

VIRAL IMMUNE EVASION OF FCRN FUNCTIONS

, 2018
Human Cytomegalovirus (HCMV) is known to evade host immunity, allowing it to persistently infect humans. Although the strategies of HCMV to evade cellular immunity is well studied, there is limited understanding on how HCMV antagonizes humoral immunity.
LIU, XIAOYANG
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, Volume 78, Issue 10, Page 1510-1521, October 2026.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Efgartigimod for treating Guillain-Barré syndrome with poor response to intravenous immunoglobulin: a case report

BMC Neurology
Background Guillain-Barré syndrome (GBS) is a peripheral neuropathy mediated by immunoglobulin G (IgG) autoantibodies, which can cause acute flaccid paralysis. Miller-Fisher syndrome (MFS) is a variant of GBS, and in some cases, MFS may overlap with GBS (
Bai Qi Hu, Sen Xiang Wu, Qiao Wen Tong, Hua Ye, Ping Ping Jin   +4 more
doaj   +1 more source