Results 61 to 70 of about 5,026 (198)

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

OR31-08 The FcRn Inhibitor Batoclimab Rapidly Normalizes Thyroid Function and Improves Clinical Outcomes in Graves’ Disease [PDF]

J Endocr Soc
Abstract Disclosure: G.J. Kahaly: The Johannes Gutenberg-University (JGU) Medical Center, Mainz, Germany receives research-associated funding from, and GJK consults for, Immunovant Inc., NY, NY, USA.​. J. Wolf: None. A. Ganz: None. M. Luffy: None. K. Albert: Employee of Immunovant, Inc. F. Ali: Employee of Immunovant, Inc. E.
Kahaly, George Jean, Wolf, Jan, Ganz, Anna-Lena, Luffy, Maximillian, Albert, Katherine, Ali, Farah, Lin, E, Macias, William   +7 more
europepmc   +3 more sources

Intestinal barrier dysfunction in inflammatory bowel diseases [PDF]

, 2009
The etiology of human inflammatory bowel diseases (IBDs) is believed to involve inappropriate host responses to the complex commensal microbial flora in the gut, although an altered commensal flora is not completely excluded.
Eri, Rajaraman, Florin, Timothy H. J., McGuckin, Michael A., Radford-Smith, Graham, Simms, Lisa A.   +4 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Case Report: Guillain−Barré syndrome temporally associated with levofloxacin exposure and improvement following efgartigimod treatment

Frontiers in Immunology
Levofloxacin, the L-isomer of the racemic fluoroquinolone ofloxacin, is a broad-spectrum antibiotic with broad clinical applications in both prophylactic and therapeutic indications.
Shiyuan Xie, Yueling Zhang, Feng Shen, Lining Wu, Yunxia Tang, Jun Li   +5 more
doaj   +1 more source

Limitations of Complement Activity Assays as Biomarkers for Ravulizumab Therapeutic Monitoring

Annals of Clinical and Translational Neurology, EarlyView.
Francesco Saccà, Ryan Pelto
wiley   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches. [PDF]

Brain Behav
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Khan A, Khan A, Rai KD, Saeed A, Kumar H, Sangtiani AK, Fatima T, Alam MT, Rajput F, Chawla S, Shah HH, Kalam H.   +11 more
europepmc   +2 more sources

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Oral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum with adjuvant saponin protects mice against highly pathogenic avian influenza A virus infection [PDF]

, 2018
Pandemics in poultry caused by the highly pathogenic avian influenza (HPAI) A virus occur too frequently globally, and there is growing concern about the HPAI A virus due to the possibility of a pandemic among humans.
Choi, JP, Goeun Lee, Hong, CP, Hwang, I, Jang, MH, Kim, DH, Kim, JH, Kim, YK, Na, YJ, Seo, YB, Sohn, EJ, Sung, YC, Yang, BG, Yun, CH   +13 more
core   +1 more source