Results 41 to 50 of about 5,026 (198)

Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins [PDF]

, 2015
Effective delivery of therapeutic proteins is a formidable challenge. Herein, using a unique polymer family with a wide-ranging set of cationic and hydrophobic features, we developed a novel nanoparticle (NP) platform capable of installing protein ...
D'Ortenzio, Mathew, Farokhzad, Omid C., Huang, Yuan, Karnik, Rohit, Lim, Jong-Min, Shan, Wei, Shi, Jinjun, Tao, Wei, Wu, Jun, Zhao, Lili, Zhu, Xi   +10 more
core   +1 more source

Cervico-vaginal immunoglobulin g levels increase post-ovulation independently of neutrophils [PDF]

, 2014
The prevalence of sexually transmitted infections (STIs) is often higher in females than in males. Although the reproductive cycle profoundly modulates local immunity in the female reproductive tract (FRT) system, significant gaps in our knowledge of the
A Arici, AK Criss, BN Jaeger, C Kaushic, C Willis, Charles J. Lacey, CR Wira, CR Wira, CR Wira, CR Wira, CR Wira, D Nardelli-Haefliger, DK Hickey, E Allen, EJ Chipperfield, EJ Chipperfield, EL Parr, ER Cobo, F Chua, F Rachman, GA Wood, GN Milligan, GN Milligan, H Hocini, HO Critchley, HO Critchley, I Puga, J Hurlimann, J Yano, JM Daley, JP Bouvet, JR Mascola, Katrein Schaefer, L Di Yacovo, L Miller, L Shang, L Shen, LA Salamonsen, LA Shrier, LC Monteiro EF, M Brannstrom, M Johansson, M Lindqvist, M Thapa, M Yoshida, MP Herman, Nades Palaniyar, Najmeeyah Brown, P Yurdakul, PA Kozlowski, Paul M. Kaye, RG Rank, S Cauci, S Rose, S Sasaki, SJ Usala, SR Bornstein, TW Jungi, V-L Roig de, W Wuttke, WB Chodirker, WH Kutteh, Y Sonoda, Z Li   +63 more
core   +4 more sources

Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis [PDF]

, 2013
PURPOSE: To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs).
Amanda L. Kauffman, Benjamin Harman, Connie Kliwinski, Edwin Ragwan, Gordon D. Powers, Haimanti Dorai, Jill Giles-Komar, John R. Mabus, Pamela J. Hornby, Philip R. Cooper, Susan H. Tam, Suzanne Thompson, Zhengyin Yan   +12 more
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion [PDF]

, 2012
BACKGROUND: Interleukin-1 receptor antagonist, a cytokine that is highly therapeutic to rheumatoid arthritis and several other inflammatory diseases, exhibits rapid blood clearance and poor retention time on the target in clinical application due to its ...
Dongxu Liu, Guoping Liu, Lei Hu, Mengyuan Liu, Xiaosong Yang, Xueping Hu, Yi Huang   +6 more
core   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Defining functional classes of Barth syndrome mutation in humans [PDF]

, 2016
The X-linked disease Barth syndrome (BTHS) is caused by mutations in TAZ; TAZ is the main determinant of the final acyl chain composition of the mitochondrial-specific phospholipid, cardiolipin.
Claypool, Steven M., Galbraith, Laura, Gottlieb, Eyal, Herndon, Jenny, Koehler, Carla M., Lu, Ya-Lin, Lu, Ya-Wen, Luyf, Angela, McCaffery, J.Michael, Pras-Raves, Mia, Van Kampen, Antoine, Vaz, Frederic M., Vervaart, Martin   +12 more
core   +2 more sources

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

The hope and reality of long‐acting hemophilia products [PDF]

, 2012
Recombinant DNA technology and protein engineering are creating hope that we can address ongoing challenges in hemophilia care such as reducing the costs of therapy, increasing the availability to the developing world, and improving the functional ...
Agersoe, Aledort, Aledort, Armstrong, Astermark, Batorova, Bergman, Bjorkman, Bjorkman, Bjorkman, Bornaes, Buyue, Carr, Casonato, Collins, Collins, Dranitsaris, Dreyfus, Dumont, Fijnvandraat, Fischer, Franchini, Ganson, Ghosh, Guh, Guh, Hay, Iorio, Ivanciu, Kenet, Knop, Lambert, Lauritzen, Lillicrap, Lindsay, Lusher, Lusher, Manco-Johnson, Mannucci, Mannucci, Mei, Metzner, Moss, Moss, Moss, Nathwani, Negrier, Nilsson, Oldenburg, Ostergaard, Pan, Parameswaran, Peters, Pipe, Pipe, Powell, Powell, Powell, Prasad, Rostin, Schulte, Shapiro, Skinner, Spira, Stonebraker, Stonebraker, Toudjarska, Van Cott, Vlot, Waters, Weimer, Weiss, Westwood, White, Wiatr   +74 more
core   +1 more source

Albumin-based cancer therapeutics for intraperitoneal drug delivery : a review [PDF]

, 2020
Albumin is a remarkable carrier protein with multiple cellular receptor and ligand binding sites, which are able to bind and transport numerous endogenous and exogenous compounds.
Al Rawahi T, Carlier C, Daugirdas JT, Dedrick RL, Fan R, Flessner MF, Goodman MD, Hartung G, Kragh-Hansen U., Lotze MT, Maltas E, Oseledchyk A, Sjobring U, Sun C, Zhao D   +14 more
core   +2 more sources