Results 31 to 40 of about 630,325 (166)

FcRn Blockade as a Targeted Therapeutic Strategy in Antibody-Mediated Autoimmune Diseases: A Focus on Warm Autoimmune Hemolytic Anemia

Antibodies
Antibody-mediated autoimmune diseases are common, can involve any organ system, and pose a large burden for patients and healthcare systems. Most antibody-mediated diseases are mediated by IgG antibodies.
Michael Sandhu, Irina Murakhovskaya
doaj   +1 more source

THE FUNCTIONAL REGULATION OF FCRN EXPRESSION AND FCRN-MEDIATED ANTIGEN PRESENTATION [PDF]

, 2009
The neonatal Fc receptor for IgG (FcRn), a major histocompatibility complex (MHC) class I-related molecule, plays an important role in IgG transport and protection.
Liu, Xindong
core   +1 more source

In Translation: FcRn across the Therapeutic Spectrum

, 2021
As an essential modulator of IgG disposition, the neonatal Fc receptor (FcRn) governs the pharmacokinetics and functions many therapeutic modalities. In this review, we thoroughly reexamine the hitherto elucidated biological and thermodynamic properties ...
Yanguang Cao, Timothy Qi
core   +1 more source

Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor

Nature Communications
Human astroviruses (HAstVs) are a leading cause of viral gastroenteritis in children worldwide. Recently the neonatal Fc receptor (FcRn) was identified as a receptor for HAstV, however the molecular basis for the FcRn-HAstV interaction remained unclear ...
Adam Lentz, Sarah Lanning, Khurshid R. Iranpur, Lena Ricemeyer, Carlos F. Arias, Rebecca M. DuBois   +5 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

FcRn inhibitors for myasthenia gravis

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of FcRn inhibitors for the maintenance treatment of myasthenia gravis in adult participants compared with control treatment ...
White, Laura M, Clay, Fiona J, Spillane, Jennifer, Dodd, Katherine C, Storms, Karen, Sussman, Jon, Keh, Ryan Yann Shern, Lilleker, James B, Forbes, Anne-Marie   +8 more
core   +3 more sources

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

A comparison of IgG distribution between FcRn^+/+ and FcRn^−/− neonatal gut.

, 2013
A. Photomicrographs illustrating gut sections from FcRn+/+ (a, b, c) and FcRn−/− (d, e, f) neonates labeled to visualize IgG (green) with goat anti-mouse IgG heavy chain Fc antibody.
Latha P. Ganesan (203662), Sudhasri Mohanty (203665), Gary S. Phillips (351937), Clark L. Anderson (203675), Jonghan Kim (203668), John M. Robinson (203671)   +5 more
core   +1 more source

Ozoralizumab, a trivalent anti-TNFα NANOBODY® compound, is resistant to rheumatoid factor-mediated modulation of FcRn-dependent recycling and immune complex uptake

Frontiers in Immunology
Rheumatoid factor (RF), an autoantibody targeting IgG, is a key diagnostic marker of autoimmune diseases, especially rheumatoid arthritis (RA). In patients with RA, high RF titers have been reported to be associated with disease severity and may ...
Mai Morimoto, Yukihisa Sawa, Chihiro Ishiwatari-Ogata, Naoki Kojima, Yasuyuki Fujii   +4 more
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source