Incorporation of albumin fusion proteins into fibrin clots in vitro and in vivo: comparison of different fusion motifs recognized by factor XIIIa [PDF]
, 2011 Background The transglutaminase activated factor XIII (FXIIIa) acts to strengthen pathological fibrin clots and to slow their dissolution, in part by crosslinking active α2-antiplasmin (α2AP) to fibrin.
William P Sheffield +1 more
core +2 more sources
Immunogenicity of long-lasting recombinant factor VIII products [PDF]
, 2016 International audienceReplacement therapy for patients with hemophilia A using plasma-derived or recombinant factor VIII (FVIII) is complicated by the short half-life of the FVIII products and by the occurrence of neutralizing antibodies in a substantial
Delignat, Sandrine +6 more
core +4 more sources
An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ. [PDF]
, 2004 Passive immunization against β-amyloid (Aβ) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD). However, traditional passive immunization approaches carry the risk of Fcγ receptor-mediated overactivation
Adolfsson, O. +20 more
core +3 more sources
Factor VIII-Fc Activates Natural Killer Cells via Fc-Mediated Interactions With CD16
Frontiers in Immunology, 2021 The most challenging complication associated with Factor VIII (FVIII) replacement therapy is the development of neutralizing anti-drug antibodies, or inhibitors, which occur in 23-35% of severe (FVIII level <1%) hemophilia A (HA) patients and are a ...
H.A. Daniel Lagassé +5 more
doaj +1 more source
Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca [PDF]
, 2015 Bears produce the most altricial neonates of any placental mammal. We hypothesized that the transition from colostrum to mature milk in bears reflects a temporal and biochemical adaptation for altricial development and immune protection.
Burchmore, Richard J. S. +9 more
core +1 more source
Development of anti-infectives using phage display: biological agents against bacteria, viruses, and parasites [PDF]
, 2012 The vast majority of anti-infective therapeutics on the market or in development are small molecules; however, there is now a nascent pipeline of biological agents in development.
Bishop-Hurley, Sharon L. +2 more
core +1 more source
Animal models of Zika virus infection, pathogenesis, and immunity [PDF]
, 2017 Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features ...
Diamond, Michael S, Morrison, Thomas E
core +2 more sources
Polymorphism in COMT is associated with IgG 3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome [PDF]
, 2015 Background Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and ...
Bauer, Sandra +9 more
core +1 more source
Antibody engineering for increased potency, breadth and half-life [PDF]
, 2015 Purpose of review: This review highlights recent developments in HIV-1 antibody engineering and discusses the effects of increased polyreactivity on serum half-lives of engineered antibodies.
Bjorkman, Pamela J. +3 more
core +1 more source
Rapid changes in Atlantic grey seal milk from birth to weaning – immune factors and indicators of metabolic strain [PDF]
, 2017 True seals have the shortest lactation periods of any group of placental mammal. Most are capital breeders that undergo short, intense lactations, during which they fast while transferring substantial proportions of their body reserves to their pups ...
Bawazeer, Sami +6 more
core +3 more sources