Results 11 to 20 of about 630,325 (166)

Phase 2 multiple-dose study of an FcRn inhibitor, rozanolixizumab, in patients with primary immune thrombocytopenia [PDF]

Blood Advances, 2020
Isidro Jarque, James Bussel, Tadeusz Robak   +2 more
exaly   +2 more sources

Real-world efficacy of eculizumab in generalized myasthenia gravis patients with poor early response to efgartigimod: a prospective cohort study [PDF]

Frontiers in Immunology
ObjectiveThe management of generalized myasthenia gravis (gMG) poses a therapeutic challenge. Efgartigimod, a neonatal Fc receptor (FcRn) inhibitor, has significant efficacy in patients with positive acetylcholine receptor (AChR) antibodies.
Xueting An, Lijie Zhu, Xiaoyu Huang, Xiaoyu Huang, Zhouao Zhang, Yong Zhang, Chao Zhang   +6 more
doaj   +2 more sources

From Payload-First Toward Dual-Mechanism Antibody-Drug Conjugates. [PDF]

Adv Mater
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Pivot X, Jung S, Harlepp S, Detappe A.
europepmc   +2 more sources

The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors. [PDF]

, 2021
The neonatal Fc receptor (FcRn) binds endogenous IgG and protects it from lysosomal degradation by transporting it back to the cell surface to re-enter the circulation, extending the serum IgG life span.
Dalakas, Marinos C., Späth, Peter J.
core   +2 more sources

Delanzomib, a Novel Proteasome Inhibitor, Combined With Adalimumab Drastically Ameliorates Collagen-Induced Arthritis in Rats by Improving and Prolonging the Anti-TNF-α Effect of Adalimumab

Frontiers in Pharmacology, 2021
Delanzomib is a novel proteasome inhibitor initially developed for treating multiple myeloma. It was found to inhibit the expression of tumor necrosis factor alpha (TNF-α). This study aimed to investigate the ameliorating effect of delanzomib on collagen-
Lei Wang, Lei Wang, Lixiong Liu, Xiaoping Hong, Dongzhou Liu, Zeneng Cheng   +5 more
doaj   +1 more source

Activation of the JNK/MAPK Signaling Pathway by TGF-β1 Enhances Neonatal Fc Receptor Expression and IgG Transcytosis

Microorganisms, 2021
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the foetus or newborn and protects the IgG from degradation. FcRn is expressed in several porcine tissues and cell types and its expression levels are regulated by immune and ...
Shaoju Qian, Chenxi Li, Xi Liu, Xiangchao Jia, Yuncai Xiao, Zili Li   +5 more
doaj   +1 more source

Delving into Molecular Pathways: Analyzing the Mechanisms of Action of Monoclonal Antibodies Integrated in IMGT/mAb-DB for Myasthenia Gravis

Vaccines, 2023
Background: Myasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs).
Rebecca Golfinopoulou, Véronique Giudicelli, Taciana Manso, Sofia Kossida   +3 more
doaj   +1 more source

Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells

Frontiers in Microbiology, 2020
Transmissible gastroenteritis virus (TGEV) is a porcine intestinal coronavirus that causes fatal severe watery diarrhea in piglets. The neonatal Fc receptor (FcRn) is the only IgG transport receptor, its expression on mucosal surfaces is triggered upon ...
Shaoju Qian, Zitong Gao, Rui Cao, Kang Yang, Yijie Cui, Shaowen Li, Shaowen Li, Shaowen Li, Xianrong Meng, Xianrong Meng, Xianrong Meng, Qigai He, Qigai He, Qigai He, Zili Li, Zili Li, Zili Li   +16 more
doaj   +1 more source

Targeting therapy in pemphigus: Where are we now and where are we going?

Heliyon, 2023
Pemphigus is a heterogeneous group of autoimmune skin disorders characterized by blistering of the skin and mucosal membranes, potentially affecting the quality of life if left unchecked.
Kailibinuer Abulikemu, Fengxia Hu, Junqin Liang, Xiaojing Kang   +3 more
doaj   +1 more source

FcRn Antagonism Leads to a Decrease of Desmoglein-Specific B Cells: Secondary Analysis of a Phase 2 Study of Efgartigimod in Pemphigus Vulgaris and Pemphigus Foliaceus

Frontiers in Immunology, 2022
BackgroundImmunoglobulin G (IgG) levels are maintained by the IgG-recycling neonatal Fc-receptor (FcRn). Pemphigus vulgaris and pemphigus foliaceus are debilitating autoimmune disorders triggered by IgG autoantibodies against mucosal and epidermal ...
Maud Maho-Vaillant, Maud Maho-Vaillant, Magdalena Sips, Marie-Laure Golinski, Marie-Laure Golinski, Gestur Vidarsson, Matthias Goebeler, Johanna Stoevesandt, Zsuzsanna Bata-Csörgő, Bianca Balbino, Peter Verheesen, Pascal Joly, Michael Hertl, Sébastien Calbo   +13 more
doaj   +1 more source