Results 21 to 30 of about 630,325 (166)

Megalin Orchestrates FcRn Endocytosis and Trafficking [PDF]

, 2022
The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport mechanism is the
Lea Maximiliane Klie, Yaman Anan, Anan, Yaman, Klie, Lea Maximiliane, Franziska Theilig, Eileen Dahlke, Hartkopf, Ariane Elisabeth, Theilig, Franziska, Ariane Elisabeth Hartkopf, Dahlke, Eileen   +9 more
core   +1 more source

Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans

JCSM Rapid Communications, 2021
Background Monoclonal antibody (mAb) immune checkpoint inhibitor (ICI) therapies have dramatically impacted oncology this past decade. However, only about one‐third of patients respond to treatment, and biomarkers to predict responders are lacking ...
Alyssa Marie M. Castillo, Trang T. Vu, Sophia G. Liva, Min Chen, Zhiliang Xie, Justin Thomas, Bryan Remaily, Yizhen Guo, Uma L. Subrayan, Travis Costa, Timothy H. Helms, Donald J. Irby, Kyeongmin Kim, Dwight H. Owen, Samuel K. Kulp, Thomas A. Mace, Mitch A. Phelps, Christopher C. Coss   +17 more
doaj   +1 more source

Efficacy and safety of the innovative monoclonal antibodies in adults with generalized myasthenia gravis: a Bayesian network analysis

Frontiers in Immunology, 2023
BackgroundA series of clinical trials support the effectiveness of monoclonal antibodies for generalized myasthenia gravis (MG) compared to the placebo, but the priority among drugs remains unclear.
Huiru Chen, Huiru Chen, Youjia Qiu, Ziqian Yin, Zilan Wang, Yanbing Tang, Hanyu Ni, Jiaye Lu, Zhouqing Chen, Yan Kong, Zhong Wang   +10 more
doaj   +1 more source

Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling. [PDF]

, 2021
Serum albumin shows slow clearance from circulation due to neonatal Fc receptor (FcRn)-mediated recycling and has been used for half-life extension. We report here fusions to a high-affinity DARPin, binding to Epithelial Cell Adhesion Molecule (EpCAM ...
Zangemeister-Wittke, Uwe, Andersen, Jan Terje, Brandl, Fabian, Irpinio, Linda, Sand, Kine M K, Schaefer, Jonas V., Sand, Kine M.K., Plückthun, Andreas, Merten, Hannes, Zimmermann, Martina, Schaefer, Jonas V, Nilsen, Jeannette   +11 more
core   +2 more sources

Characterization of Full‐Length Antibody Complexes Through HDX‐Mass Spectrometry Coupled With NMR Spectroscopy: New Insight Into Avelumab/PD‐L1 Interaction

Angewandte Chemie, EarlyView.
Combining HDX‐MS and NMR enables the mapping of epitopes and paratopes in full‐length antibody complexes, revealing transient interactions and potential artifacts. ABSTRACT Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation,
Francesca Sacco, Fabio Baroni, Angela Capolupo, Sofia Petrocchi, Jonathan Zöller, Linda Cerofolini, Pasquale Russomanno, Rebecca Calamandrei, Bianca Susini, Siyu Lin, Fabio D'Amici, Enrico Ravera, Julian Langer, Marco Fragai   +13 more
wiley   +2 more sources

Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function [PDF]

, 2020
The neonatal Fc receptor, FcRn, is expressed in many different cell types and serves several functions, some of which are cell type-specific. A function common to most cell types that express this receptor is salvage of IgG from cellular degradation ...
Challa, Dilip Kumar
core   +1 more source

Crystal structure of the compound UCB-FcRn-303 (R enantiomer) bound to FcRn_ECD.

, 2018
(A) The protein crystallized as a dimer composed of two β2m (dark grey and green) and two α-chain (light grey and blue) molecules. (B) At the interface of β2m and the α-chain, UCB-FcRn-303 (grey) occupies a binding pocket with Glycine, Cysteine ...
Marta Westwood (485655), David Fox III (278422), Christine Prosser (3864490), John Porter (768399), Lorna C. Waters (106113), James White (359733), Katharine Cain (718169), Hartmut Oschkinat (1277907), Daniel Stöppler (5244383), Nicolas Basse (2325763), Alistair Henry (2723098), Susanne Smith-Penzel (5244377), Robert Griffin (1308738), Hervé Deboves (5244380), Sebastian Kelm (2837174), Richard Taylor (34490), Richard D. Taylor (1773559), Fabien Lecomte (2408164), Alastair D. Lawson (5244386), Alex Macpherson (5244374), Tim Norman (5244389), Amy H. Sullivan (5244392), Ben Cossins (5244395), Mark D. Carr (106139), Beat H. Meier (109772)   +24 more
core   +1 more source

meyer-lab/FcRn-trafficking: Re-release to enable Zenodo DOI

, 2019
Trafficking model of FcRn to explain the effects of failed release at the cell ...
Aaron Meyer
core   +1 more source

Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn [PDF]

, 2012
The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation.
Bosze, Z, Hoffmann, OI, Cervenak, J, Farkas, A, Baranyi, M, Bender, B, Kacskovics, I, Kerekes, A, Catunda, Lemos AP, Hiripi, L   +9 more
core   +3 more sources

Factor VIII-Fc Activates Natural Killer Cells via Fc-Mediated Interactions With CD16

Frontiers in Immunology, 2021
The most challenging complication associated with Factor VIII (FVIII) replacement therapy is the development of neutralizing anti-drug antibodies, or inhibitors, which occur in 23-35% of severe (FVIII level <1%) hemophilia A (HA) patients and are a ...
H.A. Daniel Lagassé, Louis B. Hopkins, Wojciech Jankowski, Marc G. Jacquemin, Zuben E. Sauna, Basil Golding   +5 more
doaj   +1 more source