Results 51 to 60 of about 630,325 (166)

Neonatal Fc Receptor Inhibitor Therapeutics in Neuromuscular Disease

, 2023
The Neonatal Fc Receptor (FcRn) is integral to a wide variety of processes including IgG recycling, serum albumin turnover, and bacterial opsonization. Thus, targeting FcRn will increase antibody degradation including pathogenic IgGs.
Daniel L. Menkes, Jaffry, Kazim, Shaikh, Anam, Kothari, Om, Nizar Souayah, Mustafa Jaffry, Kazim Jaffry, Mandava, Kranthi, Kranthi Mandava, Jaffry, Mustafa, Menkes, Daniel L, Om Kothari, Souayah, Nizar, Anam Shaikh   +13 more
core   +1 more source

Effectiveness and safety of efgartigimod in patients with anti‐NMDAR or anti‐LGI1 encephalitis and its 18F‐DPA714 PET imaging evaluation: A multicenter, single‐arm, prospective, observational real‐world study

Neuroprotection, EarlyView.
Abstract Background Efgartigimod disrupts the recycling of pathogenic IgG autoantibodies and may represent a candidate therapy for autoimmune encephalitis. This real‐world study evaluated the clinical efficacy, safety, and impact of efgartigimod on brain inflammation.
Huanyu Meng, Siqi Tu, Yifan Zhou, Ruinan Shen, Xiaoyu Chen, Zhaozhao Cheng, Limei Wang, Yan Wu, Jie Lu, Shengjun Wang, Yan Xu, Wanhui Lin, Sheng Chen   +12 more
wiley   +1 more source

Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method

, 2023
A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding ...
Thomas Müller, Carolin Tasser, Kristina Ellwanger, Michael Tesar, Joachim Koch, Ivica Fucek, Ute Schniegler-Mattox   +6 more
core   +1 more source

Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia

Pharmacological Research
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients.
Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C. Remaily, Emma J. Montgomery, Travis Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, Alyssa Marie M. Castillo, Samuel K. Kulp, Xiaokui Mo, Sridhar Nimmagadda, Paul Gregorevic, Dwight H. Owen, Latha P. Ganesan, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps   +20 more
doaj   +1 more source

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source

Albumin Binding to FcRn:  Distinct from the FcRn−IgG Interaction^†

, 2016
The MHC-related Fc receptor for IgG (FcRn) protects albumin and IgG from degradation by binding both proteins with high affinity at low pH in the acid endosome and diverting both from a lysosomal pathway, returning them to the extracellular compartment ...
Chaity Chaudhury (2643301), Daniel C. Carter (2643304), Charles L. Brooks (61231), Clark L. Anderson (203675), John M. Robinson (203671)   +4 more
core   +1 more source

Case Report: Guillain−Barré syndrome temporally associated with levofloxacin exposure and improvement following efgartigimod treatment

Frontiers in Immunology
Levofloxacin, the L-isomer of the racemic fluoroquinolone ofloxacin, is a broad-spectrum antibiotic with broad clinical applications in both prophylactic and therapeutic indications.
Shiyuan Xie, Yueling Zhang, Feng Shen, Lining Wu, Yunxia Tang, Jun Li   +5 more
doaj   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Distribution of FcRn Across Species and Tissues

, 2017
The neonatal Fc receptor (FcRn) is a major histocompatibility complex class I type molecule that binds to, transports, and recycles immunoglobulin G (IgG) and albumin, thereby protecting them from lysosomal degradation.
Sari Latvala, Annika Herrmann, Sven Kronenberg, Bjoern Jacobsen, Michael B. Otteneder   +4 more
core   +1 more source

Comparison of distribution of IgG between FcRn^+/+ and FcRn^−/− YS endoderm.

, 2013
A. Photomicrographs illustrating YS sections from FcRn+/+ (a, b, c) and FcRn−/− (d, e, f) YS labeled to visualize IgG (green) as was done in Fig. 5.
Latha P. Ganesan (203662), Sudhasri Mohanty (203665), Gary S. Phillips (351937), Clark L. Anderson (203675), Jonghan Kim (203668), John M. Robinson (203671)   +5 more
core   +1 more source