Results 81 to 90 of about 630,325 (166)

Nipocalimab in Early‐Onset Severe Hemolytic Disease of the Fetus and Newborn

Pediatric Discovery, EarlyView.
Aditya Hemedra Bhatt, Somashekhar Marutirao Nimbalkar, Dipen Vasudev Patel, Reshma Kushal Pujara   +3 more
wiley   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, Volume 15, Issue 34, 11 September 2026.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

FcRn expression along the linear length of neonatal intestine.

, 2013
A. An immunoblot using rabbit anti-rat FcRn antibody shows FcRn expression along a 7 cm length of neonatal intestine cut into 1 cm pieces from pylorus through duodenum and into jejunum, comparing tissue lysates from FcRn+/+ and FcRn−/− strains.
Latha P. Ganesan (203662), Sudhasri Mohanty (203665), Gary S. Phillips (351937), Clark L. Anderson (203675), Jonghan Kim (203668), John M. Robinson (203671)   +5 more
core   +1 more source

Oral Corticosteroid and Nonsteroidal Immunosuppressant Therapy Use in Patients with Myasthenia Gravis Receiving Ravulizumab, Eculizumab, or Efgartigimod in the USA

Neurology and Therapy
Introduction Oral corticosteroids (OCSs) and nonsteroidal immunosuppressant therapies (NSISTs) remain widely used for the clinical management of patients with generalized myasthenia gravis (gMG), despite well-documented risks.
Francesco Saccà, Justin Lee, Karen S. Yee, Nicholas J. Silvestri, Guido Sabatella   +4 more
doaj   +1 more source

Monoclonal antibodies directed against human FcRn and their applications.

, 2012
The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers.
Pesavento, Emanuele, Emanuele Pesavento, Proetzel, Gabriele, Sun, Victor Z, Victor Z. Sun, Gregory J. Christianson, Gabriele Proetzel, Derry C. Roopenian, Akilesh, Shreeram, Roopenian, Derry C, Shreeram Akilesh, Christianson, Gregory J   +11 more
core   +2 more sources

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

FcRn

, 2017
En este objeto de aprendizaje estudiamos el receptor neonatal de IgG, desde su estructura hasta las funciones fisiolçogicas que desempeñahttps://polimedia.upv.es/visor/?id=a44b4ad0-46a7-11e7-9b33-83cdd974e088Sirera Pérez, R. (2017). FcRn.
Sirera Pérez, Rafael
core  

Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function

, 2016
The neonatal Fc receptor, FcRn, is expressed in many different cell types and serves several functions, some of which are cell type-specific. A function common to most cell types that express this receptor is salvage of IgG from cellular degradation ...
Challa, Dilip Kumar
core   +1 more source

Cancer cell‐selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumour immunotherapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong, Yile Wang, Yunqi Zhao, Lu Wang, Zhimin Fan, Yongqian Shu, Jinke Wang   +6 more
wiley   +1 more source