Results 161 to 170 of about 3,265 (192)

Cuproptosis and Orthopedic Diseases: Molecular Mechanisms of Copper Metabolic Imbalance in the Skeletal System and Clinical Translation Prospects. [PDF]

Orthop Res Rev
Huang F, Wang J, Pan X.
europepmc   +1 more source

Silencing SLC31A1 attenuates high glucose plus copper-induced cuproptosis-like signaling, oxidative stress, and barrier dysfunction in human retinal microvascular endothelial cells. [PDF]

Int J Ophthalmol
Li Y, Chen M, Dong HG.
europepmc   +1 more source

CuAgent provides a RAG-assisted intelligent framework to investigate cuproptosis. [PDF]

Sci Rep
Zhang C, Bao J, Yu H, Cui H, Li X, Ma J, Zhao N.   +6 more
europepmc   +1 more source

Beyond apoptosis: harnessing natural products to target alternative regulated cell death for overcoming multidrug resistance in cancer. [PDF]

Front Oncol
Yang C, Wang J, Ni B, Zhan W.
europepmc   +1 more source

Musculoskeletal disorders: does cuproptosis hold the key? [PDF]

Front Cell Dev Biol
Wang C, Liu D, Ye Y, Cui L, Gong S, Liu H, Xie S.   +6 more
europepmc   +1 more source

A Novel Oncogenic Role of FDX1 in Human Melanoma Related to PD-L1 Immune Checkpoint

International Journal of Molecular Sciences, 2023
The aim of this study was to evaluate the association between Ferredoxin 1 (FDX1) expression and the prognostic survival of tumor patients and predict the efficacy of immunotherapy response to antitumor drug sensitivity.
Rongxin Zhang, Jiahua Liang
exaly   +2 more sources

Prognostic, Clinicopathological, and Function of Key Cuproptosis Regulator FDX1 in Clear Cell Renal Cell Carcinoma

Genes, 2022
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cancer. Cuproptosis is suggested to be a novel therapy target for cancer treatment.
Song Zeng, Xiaopeng Hu, He Zhang
exaly   +2 more sources

FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery

Proceedings of the National Academy of Sciences of the United States of America, 2023
Recent studies have uncovered the therapeutic potential of elesclomol (ES), a copper-ionophore, for copper deficiency disorders. However, we currently do not understand the mechanism by which copper brought into cells as ES–Cu(II) is released and delivered to cuproenzymes present in different subcellular compartments. Here, we have
Yuteng Zhang, Martina Ralle, Tai-Yen Chen   +2 more
exaly   +3 more sources

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FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis

Apoptosis: an International Journal on Programmed Cell Death, 2023
Cuproptosis is a new form of programmed cell death, which is associated with the mitochondrial TCA (tricarboxylic acid) cycle. But the functions of cuproptosis in endometriosis progression are still unknown. Here, we find that cuproptosis suppresses the growth of endometriosis cells and the growth of ectopic endometrial tissues in a mouse model.
Zhenhai Yu, Yonghong Sun, Chune Ren
exaly   +3 more sources

FDX1 Is Required for the Biogenesis of Mitochondrial Cytochrome c Oxidase in Mammalian Cells

Journal of Molecular Biology, 2023
Ferredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe-S) proteins that function as electron transfer proteins in diverse metabolic pathways. Mammalian mitochondria contain two ferredoxins, FDX1 and FDX2, which share a high degree of structural similarity but exhibit different functionalities.
Mohammad Zulkifli, Adriana U. Okonkwo, Vishal M. Gohil   +2 more
openaire   +2 more sources