Results 161 to 170 of about 2,914 (186)

FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis

Apoptosis: an International Journal on Programmed Cell Death, 2023
Cuproptosis is a new form of programmed cell death, which is associated with the mitochondrial TCA (tricarboxylic acid) cycle. But the functions of cuproptosis in endometriosis progression are still unknown. Here, we find that cuproptosis suppresses the growth of endometriosis cells and the growth of ectopic endometrial tissues in a mouse model.
Yonghong Sun, Lan Liu, Xiaoyun Wang
exaly   +3 more sources

Liraglutide Improves PCOS Symptoms in Rats by Targeting FDX1

Reproductive Sciences
Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder characterized by ovulatory disorders, hyperandrogenemia, and polycystic changes in the ovaries. FDX1 is a ferredoxin-reducing protein on human mitochondria that plays an important role in steroid anabolism.
Fang Wang, Tang Na
exaly   +3 more sources

Functional Characterization of Fdx1: Evidence for an Evolutionary Relationship between P450-Type and ISC-Type Ferredoxins

Journal of Molecular Biology, 2011
Ferredoxins are ubiquitous proteins with electron transfer activity involved in a variety of biological processes. In this work, we investigated the characteristics and function of Fdx1 from Sorangium cellulosum So ce56 by using a combination of bioinformatics and of biochemical/biophysical approaches.
K. M. Ewen, F. Hannemann, S. Iametti, A. Morleo, R. Bernhardt   +4 more
openaire   +3 more sources

The CEBPA/FDX1 axis elevates sensitivity to cuproptosis in lung adenocarcinoma cells

Biochimica Et Biophysica Acta - General Subjects
The recent introduction of "cuproptosis" into the oncological lexicon has opened up new horizons for cancer therapy, yet our understanding of how this process operates in lung adenocarcinoma (LUAD) is still limited. In this work we have investigated the core genetic factors and provided theoretical support for the application of cuproptosis in the ...
Kexin Luo
exaly   +3 more sources

Prognostic, Clinicopathological, and Function of Key Cuproptosis Regulator FDX1 in Clear Cell Renal Cell Carcinoma

Genes, 2022
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cancer. Cuproptosis is suggested to be a novel therapy target for cancer treatment.
Song Zeng, He Zhang, Xiaopeng Hu
exaly   +2 more sources

FDX1 Is Required for the Biogenesis of Mitochondrial Cytochrome c Oxidase in Mammalian Cells

Journal of Molecular Biology, 2023
Ferredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe-S) proteins that function as electron transfer proteins in diverse metabolic pathways. Mammalian mitochondria contain two ferredoxins, FDX1 and FDX2, which share a high degree of structural similarity but exhibit different functionalities.
Mohammad Zulkifli, Adriana U. Okonkwo, Vishal M. Gohil   +2 more
openaire   +2 more sources

FDX1 Regulates the Phosphorylation of ATM, DNA-PKcs Akt, and EGFR and Affects Radioresistance Under Severe Hypoxia in the Glioblastoma Cell Line T98G

International Journal of Molecular Sciences
Hypoxic cells exhibit radioresistance, which is associated with poor prognosis in cancer patients. Understanding the molecular mechanisms underlying radioresistance in hypoxic tumor cells is crucial for improving radiotherapy efficacy.
Takuma Hashimoto, Khaled Hatabi
exaly   +2 more sources

Targeting cuproptosis by FDX1 in acetaminophen-induced liver injury

Chemico-Biological Interactions
Acetaminophen (APAP) overdose is the most common etiology of acute drug-induced liver injury (DILI) worldwide. Although oxidative stress, apoptosis, and necrosis are well-recognised mechanisms, the involvement of cuproptosis, a newly identified, copper-dependent form of regulated cell death, remains poorly understood.
Yan Liu, Ying Yang, Baizhao Peng, Zhongyue Ou, Anna Zuo, Zihao Jiang, Chuanghai Wu, Hiu Yee Kwan, Ke Ma, Lin Yu, Xiaoshan Zhao   +10 more
openaire   +2 more sources

The Role of Cuproptosis Key Factor FDX1 in Gastric Cancer

Current Pharmaceutical Biotechnology
Background: Gastric cancer is a common malignant tumor of the digestive tract, both domestically and internationally. It has high incidence and mortality rates, posing a significant threat to human health. The levels of blood copper are elevated in patients with gastric cancer.
Qiqi, Zhao, Miao, Yu, Xueqin, Du, Yuan, Li, Juantao, Lv, Xianglai, Jiang, Xiaomei, Chen, Anqi, Wang, Xiaojun, Yang   +8 more
openaire   +2 more sources

Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity

British Journal of Pharmacology
AbstractBackground and PurposeDoxorubicin (DOX), an anthracycline chemotherapeutic agent, whose use is limited owing to its dose‐dependent cardiotoxicity. Mitochondrial oxidative stress plays a crucial role in the pathogenesis of DOX‐induced cardiotoxicity (DIC).
Jiajia, Wei, Guozhen, Lan, Wenfang, Zhang, Wang, Ran, Yu, Wei, Xin, Liu, Yuandong, Zhang, Qihai, Gong, Haibo, Li, Jianmei, Gao   +9 more
openaire   +2 more sources