Results 171 to 180 of about 3,265 (192)

Liraglutide Improves PCOS Symptoms in Rats by Targeting FDX1

Reproductive Sciences
Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder characterized by ovulatory disorders, hyperandrogenemia, and polycystic changes in the ovaries. FDX1 is a ferredoxin-reducing protein on human mitochondria that plays an important role in steroid anabolism.
Fang Wang
exaly   +3 more sources

FDX1 Regulates the Phosphorylation of ATM, DNA-PKcs Akt, and EGFR and Affects Radioresistance Under Severe Hypoxia in the Glioblastoma Cell Line T98G

International Journal of Molecular Sciences
Hypoxic cells exhibit radioresistance, which is associated with poor prognosis in cancer patients. Understanding the molecular mechanisms underlying radioresistance in hypoxic tumor cells is crucial for improving radiotherapy efficacy.
Takuma Hashimoto, Yoshio Hosoi, Khaled Hatabi   +2 more
exaly   +2 more sources

The Role of Cuproptosis Key Factor FDX1 in Gastric Cancer

Current Pharmaceutical Biotechnology
Background: Gastric cancer is a common malignant tumor of the digestive tract, both domestically and internationally. It has high incidence and mortality rates, posing a significant threat to human health. The levels of blood copper are elevated in patients with gastric cancer.
Qiqi, Zhao, Miao, Yu, Xueqin, Du, Yuan, Li, Juantao, Lv, Xianglai, Jiang, Xiaomei, Chen, Anqi, Wang, Xiaojun, Yang   +8 more
openaire   +2 more sources

Targeting cuproptosis by FDX1 in acetaminophen-induced liver injury

Chemico-Biological Interactions
Acetaminophen (APAP) overdose is the most common etiology of acute drug-induced liver injury (DILI) worldwide. Although oxidative stress, apoptosis, and necrosis are well-recognised mechanisms, the involvement of cuproptosis, a newly identified, copper-dependent form of regulated cell death, remains poorly understood.
Yan Liu, Ying Yang, Baizhao Peng, Zhongyue Ou, Anna Zuo, Zihao Jiang, Chuanghai Wu, Hiu Yee Kwan, Ke Ma, Lin Yu, Xiaoshan Zhao   +10 more
openaire   +2 more sources

The CEBPA/FDX1 axis elevates sensitivity to cuproptosis in lung adenocarcinoma cells

Biochimica Et Biophysica Acta - General Subjects
The recent introduction of "cuproptosis" into the oncological lexicon has opened up new horizons for cancer therapy, yet our understanding of how this process operates in lung adenocarcinoma (LUAD) is still limited. In this work we have investigated the core genetic factors and provided theoretical support for the application of cuproptosis in the ...
Kexin Luo
exaly   +3 more sources

Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity

British Journal of Pharmacology
AbstractBackground and PurposeDoxorubicin (DOX), an anthracycline chemotherapeutic agent, whose use is limited owing to its dose‐dependent cardiotoxicity. Mitochondrial oxidative stress plays a crucial role in the pathogenesis of DOX‐induced cardiotoxicity (DIC).
Jiajia, Wei, Guozhen, Lan, Wenfang, Zhang, Wang, Ran, Yu, Wei, Xin, Liu, Yuandong, Zhang, Qihai, Gong, Haibo, Li, Jianmei, Gao   +9 more
openaire   +2 more sources

Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population

Human Immunology, 2015
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, and its pathogenesis is influenced by both genetic and environmental factors. In this study, we evaluated 23 tag single-nucleotide polymorphisms (tSNPs) in 21 IgAN-associated genes, in 200 subjects with IgAN and 310 healthy gender- and age-matched unrelated control subjects
Dan, Niu, Ya, Gao, Liyi, Xie, Jiping, Sun, Wanhong, Lu, Gang, Jin, Yaning, Hao, Yali, Zhang, Aiping, Yin, Yingzhou, Geng, Wenjing, Zhang, Cuiping, Chen, Shengbin, Li   +12 more
openaire   +2 more sources

Punicalagin Targets FDX1 to Induce Cuproptosis for the Treatment of Gastric Cancer

IUBMB Life
ABSTRACT Gastric cancer represents the fifth most common malignancy globally and the third leading cause of cancer‐related deaths. Due to its insidious early symptoms and frequent metastasis at diagnosis, the survival rate remains dismal.
Yuan‐yuan Fang, Si‐yi Zhang, Chuan‐yu Leng, null Jing‐Lv, Shu‐fen Zhao, Xue‐ying Sun, null Xin‐Li, Yang‐yang Lu, null Bing‐Wang, Wei‐wei Qi   +9 more
openaire   +2 more sources

Cuproptosis-Related Gene FDX1 Identified as a Potential Target for Human Ovarian Aging

Reproductive Sciences
Cuproptosis is a recently discovered mode of cell death that has garnered attention due to its association with various diseases. However, the intricate genetic relationship between cuproptosis and ovarian aging has remained largely unexplored.
Chia-Chun Wu, Chia-Jung Li, Li-Te Lin, Pei-Hsuan Lin, Zhi-Hong Wen, Jiin-Tsuey Cheng, Kuan-Hao Tsui   +6 more
openaire   +2 more sources

Mettl1 mitigates sepsis-induced cardiomyopathy via inhibition of FDX1-dependent cuproptosis

Gene
Sepsis-induced cardiomyopathy (SICM) significantly contributes to sepsis-related mortality, yet its molecular mechanisms remain incompletely understood. Here, we identify cuproptosis-a copper-dependent mitochondrial cell death pathway-as a critical driver of SICM pathogenesis.
Wei, Siang, Wang, Guoyun, Feng, Yan, Lin, Wenji   +3 more
openaire   +2 more sources