Results 101 to 110 of about 480,216 (163)

An Examination of an Alternative Use for the Fear-Potentiated Startle Paradigm and the Effects of Angiotensin Type 1 Receptor Inhibition on Extinction Learning

, 2019
Background – PTSD is a chronic and debilitating mental illness with limited available treatments. New medications, including Angiotensin Type 1 Receptor inhibitors, have been found to improve extinction learning retention in rodents and could be a means ...
Seidenberg, Jessica
core   +1 more source

Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats

, 2002
NMDA receptor antagonists block conditioned fear extinction when injected systemically and also when infused directly into the amygdala. Here we evaluate the ability ofd-cycloserine (DCS), a partial agonist at the strychnine-insensitive glycine ...
Michael Davis, Kwok-Tung Lu, David L. Walker, Kerry J. Ressler   +3 more
core   +1 more source

The Investigation of the Novel Peptide TUF1 in Fear Potentiated Startle

, 2011
The goal of this study is to determine the role of TUF1 and to measure if the administration of this peptide into the ventricles alters fear responses by affecting the acquisition and/or expression of acoustic startle.Additional contributors: Jiva Dimova;
Reise, Kathryn
core  

Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial

Translational Psychiatry
Pavlovian fear conditioning is widely used as a pre-clinical model to investigate methods for prevention and treatment of anxiety and stress-related disorders.
Yanfang Xia, Jelena Wehrli, Aslan Abivardi, Madalina Hostiuc, Birgit Kleim, Dominik R. Bach   +5 more
doaj   +1 more source

ASSESSMENT OF NEUROTENSIN RECEPTOR AGONIST EFFECTS ON FEAR-POTENTIATED STARTLE [PDF]

, 2016
Systemic administration of the NTS1 receptor agonist PD149163 has exhibited anxiolytic effects in male rats. The present study sought to further evaluate the potential anxiolytic effects of PD149163 by assessing this compound in both male and female ...
Vanden Avond, Mark Aaron
core  

Characterizing the Prevalence of Psychiatric Conditions and Fear-Potentiated Startle Response in Civilians with a History of Trauma and Seizures

Chronic Stress
Background Depression, posttraumatic stress disorder (PTSD), and suicidality are more prevalent among people with seizures, but few studies exist in low-resourced minoritized populations.
Trinidi Prochaska, Helena Zeleke, Sean T. Minton, Abigail Powers, Vasiliki Michopoulos, Jon T. Willie, Daniel L. Drane, Tanja Jovanovic, Sanne J.H. van Rooij   +8 more
doaj   +1 more source

On the temporary nature of disruption of fear-potentiated startle following PKMζ inhibition in the amygdale

Frontiers in Behavioral Neuroscience, 2011
Karim eNader
doaj   +1 more source

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Fear-potentiated startle: A neural and pharmacological analysis

Behavioural Brain Research, 1993
The fear-potentiated startle paradigm has proven to be a useful system with which to analyze neural systems involved in fear and anxiety. This test measures conditioned fear by an increase in the amplitude of a simple reflex (the acoustic startle reflex) in the presence of a cue previously paired with a shock. Fear-potentiated startle is sensitive to a
Michael E. Davis, William Falls, Serge Campeau   +2 more
exaly   +3 more sources

Baseline and fear-potentiated startle in panic disorder patients

Biological Psychiatry, 1994
The present study investigated whether patients with panic disorder had an increase in the startle response and whether this effect, if present, was specific to anticipatory anxiety. The eyeblink component of the acoustic startle reflex was measured in a paradigm involving the anticipation of electric shocks (fear-potentiated startle) in 34 patients ...
Rezvan Ameli, Christian Grillon, Scott Woods   +2 more
exaly   +3 more sources

Fear‐Potentiated Startle and Light‐Enhanced Startle Models in Drug Discovery

Current Protocols in Pharmacology, 2008
AbstractDescribed in this unit are the fear‐potentiated startle (FPS) and light‐enhanced startle (LES) tests. These protocols have proven reliable in detecting the anxiolytic properties of test compounds. The principle of these tests is that the magnitude of the acoustic startle reflex is an index of anxiety. The FPS test includes two training sessions
Groenink, L., Bijlsma, E.Y., Olivier, B.
openaire   +5 more sources