A novel drug management system in the Febuxostat versus Allopurinol Streamlined Trial:A description of a pharmacy system designed to supply medications directly to patients within a prospective multicenter randomised clinical trial [PDF]
, 2016 Background: Trials of investigational medicinal products are required to adhere to strict guidelines with regard to the handling and supply of medication.
Flynn, Robert W V +4 more
core +2 more sources
Copper‐Catalyzed Three‐Component Selective 1,4‐Amino Oxygenation of 1,3‐Dienes
Angewandte Chemie, EarlyView.Enclosed is a copper‐catalyzed selective 1,4‐amino oxgenation of 1,3‐dienes with the presence of a strong Brønsted acid. This three‐component transformation offers a novel and powerful approach to construct (E)‐1,4‐allylic amino oxygenated motifs by the simultaneous installation of structurally diverse alkylamines and alcohols directly onto 1,3‐dienes.
Guangshou Feng +2 more
wiley +2 more sources
PLoS Medicine, 2020 BackgroundAn elevated level of serum uric acid (SUA) is associated with an increased risk of cardiovascular disease. Pharmacological intervention with urate-lowering agents, such as the conventional purine analogue xanthine oxidase (XO) inhibitor ...
Atsushi Tanaka +23 more
doaj +1 more source
Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative [PDF]
, 2014 We aimed to develop evidence-based multinational recommendations for the diagnosis and management of gout. Using a formal voting process, a panel of 78 international rheumatologists developed 10 key clinical questions pertinent to the diagnosis and ...
Aletaha, Daniel +29 more
core +1 more source
Journal of International Medical Research, 2020 Objective To measure the effect of febuxostat on the serum levels of uric acid (sUA) and the proinflammatory cytokines interleukin (IL)-6, IL-17 and tumour necrosis factor-α (TNF-α) in Chinese Han patients with gout and hyperuricaemia.
Yuan-Yuan Huang +4 more
doaj +1 more source
Journal of International Medical Research, 2021 Objective Heart failure (HF) is a common and highly morbid cardiovascular disorder. Oxidative stress worsens HF, and uric acid (UA) is a useful oxidative stress marker.
Satoshi Suzuki +17 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity.
Hayder M. Al-Kuraishy +10 more
doaj +1 more source
Long-term inhibition of xanthine oxidase by febuxostat does not decrease blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. [PDF]
PLoS ONE, 2013 Xanthine oxidase and its products, uric acid and ROS, have been implicated in the pathogenesis of cardiovascular disease, such as hypertension.
Theodora Szasz +5 more
doaj +1 more source
Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function [PDF]
, 2014 Xanthine oxidase (XOD) is an enzyme which plays a central role in purine catabolism by converting hypoxanthine into xanthine and then further into uric acid.
Abooali, Maryam +5 more
core +1 more source
Disseminated cutaneous gout: a rare manifestation of a common disease [PDF]
, 2020 Disseminated cutaneous gout is a rare atypical cutaneous manifestation of gout in which widespread dermal and subcutaneous tophi develop at extra-articular body sites.
Adler, Brandon L +4 more
core