Results 51 to 60 of about 9,527 (221)

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]

, 2015
Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju, Chemaitilly, Wassim, Frase, Sharon, Green, Daniel M, Janke, Laura, Lynch, John, Morgan, Jessica A, Opferman, Joseph T, Panetta, John C, Schuetz, John D, Wang, Yao, Zheng, Jie   +11 more
core   +1 more source

Urate-lowering therapy for CKD patients with asymptomatic hyperuricemia without proteinuria elucidated by attribute-based research in the FEATHER Study

Scientific Reports, 2022
Attribute-based medicine is essential for patient-centered medicine. To date, the groups of patients with chronic kidney disease (CKD) requiring urate-lowering therapy are clinically unknown.
Hiroshi Kataoka, Toshio Mochizuki, Mamiko Ohara, Yuki Tsuruta, Naomi Iwasa, Rie Yoshida, Ken Tsuchiya, Kosaku Nitta, Kenjiro Kimura, Tatsuo Hosoya, the FEATHER Investigators   +10 more
doaj   +1 more source

Switching from allopurinol to febuxostat: efficacy and safety in the treatment of hyperuricemia in renal transplant recipients

Renal Failure, 2019
The aim of this study was to evaluate the efficacy and tolerability of febuxostat in renal transplant recipients who were previously treated with allopurinol (the daily oral dose is 100 mg).
Yanchun Li, Min Liu, Xuelei Zhang, Yuewu Lu, Juan Meng   +4 more
doaj   +1 more source

African American patients with gout: efficacy and safety of febuxostat vs allopurinol

BMC Musculoskeletal Disorders, 2012
Background African Americans are twice as likely as Caucasians to develop gout, but they are less likely to be treated with urate-lowering therapy (ULT).
Wells Alvin F, MacDonald Patricia A, Chefo Solomon, Jackson Robert L   +3 more
doaj   +1 more source

Cardiovascular Safety of Febuxostat and Allopurinol in Hyperuricemic Patients With or Without Gout: A Network Meta-Analysis

Frontiers in Medicine, 2021
Background: Hyperuricemia is a common metabolic disease and has become a public health problem because of its increasing prevalence and association with comorbidities.
Shengzhao Zhang, Shengzhao Zhang, Ting Xu, Ting Xu, Qingyang Shi, Sheyu Li, Sheyu Li, Ling Wang, Zhenmei An, Na Su, Na Su   +10 more
doaj   +1 more source

A New Regimen for Induction of Metabolic Syndrome and the Effect of Febuxostat in Ovariectomized Female Albino Rats

SVU - International Journal of Medical Sciences, 2021
Background: Metabolic syndrome (MetS) is increasing worldwide and correlates with serum uric acid and high fat combined with highfructose diet (HFFD). Fat raises triglycerides. Fructose increases uric acid. We hypothesized that HFFD in menopause may have
Rana Toghan, Rehab H. Abdel-Aziz*, Tahany Abbas, Khaled A. Abdel-Sater   +3 more
doaj   +1 more source

Gout - a guide for the general and acute physicians. [PDF]

, 2017
Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population in the UK. It is also the only arthritis that has the potential to be cured with safe, inexpensive and well tolerated urate-lowering treatments, which reduce ...
Abhishek, A, Doherty, M, Roddy, E
core   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells.

PLoS ONE
Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis.
Karel H van der Pol, Jan Koenderink, Jeroen J M W van den Heuvel, Petra van den Broek, Janny Peters, Imke D W van Bunningen, Jeanne Pertijs, Frans G M Russel, Jim Koldenhof, Wim J Morshuis, Joris van Drongelen, Tom J J Schirris, Andries van der Meer, Gerard A Rongen   +13 more
doaj   +1 more source

FEBUXOSTAT FOR TREATMENT OF CHRONIC HYPERURICEMIA IN GOUT PATIENTS

Медицинский совет, 2017
Febuxostat, a selective  inhibitor of isoforms xantinoxydoreductase, it is an alternative to a limited number of medications to reduce urates levels  applied in recent decades.
M. S. Petrova, V. I. Mazurov, O. V. Inamova   +2 more
doaj   +1 more source