Results 81 to 90 of about 9,243 (198)

Nitrite supplementation alleviates cerebrovascular dysfunction in chronically stressed mice, but cognitive decline remains

Experimental Physiology, EarlyView.
Abstract This study aimed to determine whether sodium nitrite supplementation prevented chronic stress‐induced cerebrovascular dysfunction and cognitive decline. We hypothesize that nitrite supplementation will prevent the oxidative environment and cerebrovascular dysfunction associated with chronic stress and maintain cognitive health.
Emily Burrage, Tyler Coblentz, Saina S. Prabhu, Nicole M. Eminhizer, Ryan Childers, Randall W. Bryner, Sara E. Lewis, Brooke A. Maxwell, Evan R. DeVallance, Eric E. Kelley, Paul D. Chantler   +10 more
wiley   +1 more source

Sleep Architecture Alterations Following High‐Dose Steroid Pulse Therapy: A Pilot Study Using a Portable Electroencephalogram‐Based Device

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
High‐dose steroid pulse therapy markedly reduces total sleep time, REM, and NREM sleep, as objectively demonstrated for the first time using a portable EEG‐based device. ABSTRACT Background Sleep disturbance is a common side effect of high‐dose steroid pulse therapy (SPT).
Hiroki Endo, Yuki Shigetsura, Misaki Chahara, Keisuke Kido, Etsuro Nakanishi, Sakiho Ueda, Kimitoshi Kimura, Akira Kuzuya, Hirotsugu Kawashima, Riki Matsumoto, Masahiro Tsuda, Shunsaku Nakagawa, Tomohiro Terada   +12 more
wiley   +1 more source

Febuxostat methanol solvate

Acta Crystallographica Section E, 2011
In the title compound {systematic name: [2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid (febuxostat) methanol monosolvate}, C16H16N2O3S·CH4O, the benzene and thiazole rings in the febuxostat molecule are twisted at 5.3 ...
Qi-Ying Jiang, Jing-Jing Qian, Jian-Ming Gu, Gu-Ping Tang, Xiu-Rong Hu   +4 more
doaj   +1 more source

Firsekibart as a Prophylactic Treatment for Acute Gout Flare in Participants Initiating Urate‐Lowering Therapy: A Phase 2, Randomized, Open‐Label, Multicenter, Active‐Controlled Trial

ACR Open Rheumatology, Volume 7, Issue 11, November 2025.
Objective To evaluate the efficacy and safety of firsekibart versus colchicine for prophylaxis against acute gout flares in participants initiating urate‐lowering therapy (ULT). Methods In this randomized, multicenter, open‐label, active‐controlled, phase 2 trial, participants were randomized (1:1:1) to receive a single subcutaneous injection of ...
Yiyun Yu, Yu Xue, Jiankang Hu, Ning Zhang, Rongbin Li, Hongtao Guo, Long Qian, Wei Gou, Jing Yang, Li Mao, Jing Yu, Shengyun Liu, Qian Xu, Tianhong Luo, Hejian Zou   +14 more
wiley   +1 more source

Acute kidney injury associated with febuxostat and allopurinol: a post-marketing study

Arthritis Research & Therapy, 2019
Background For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment.
Amayelle Rey, Benjamin Batteux, Solène M. Laville, Justine Marienne, Kamel Masmoudi, Valérie Gras-Champel, Sophie Liabeuf   +6 more
doaj   +1 more source

Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature [PDF]

, 2017
BACKGROUND: This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor. CASE PRESENTATION: A 65-year-old white woman had tumor lysis syndrome, which represent a dangerous oncological emergency.
Giulia Malaguarnera, Michele Malaguarnera, Michele Vecchio, Roberto Madeddu, Saverio Latteri, Vito Emanuele Catania   +5 more
core   +1 more source

Dual‐Energy CT Demonstrates Multiple Urate Crystal Deposits in the Sternoclavicular Joint, Cricoid Cartilage, and Cervical Ligaments

Clinical Case Reports, Volume 13, Issue 11, November 2025.
This case image describes a patient with a long history of gout presenting primarily with limited cervical mobility. Dual‐energy computed tomography revealed multiple urate crystal deposits in the sternoclavicular joint, cricoid cartilage, and cervical ligaments.
Chenyang Zhang, Ziyu Wang, Zhihao Zhang, Ertao Jia   +3 more
wiley   +1 more source

Severe Hypouricemia Impairs Endothelium‐Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo‐Controlled, and Crossover Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Uric acid (UA) is a plasmatic antioxidant that has possible effects on blood pressure. The effects of UA on endothelial function are unclear. We hypothesize that endothelial function is not impaired unless significant UA depletion is achieved ...
Benjamin De Becker, Catherine Coremans, Martin Chaumont, Cédric Delporte, Pierre Van Antwerpen, Thierry Franck, Alexandre Rousseau, Karim Zouaoui Boudjeltia, Pierre Cullus, Philippe van de Borne   +9 more
doaj   +1 more source

Recurrent Priapism After Living Donor Kidney Transplantation Requiring Bilateral T‐Shunt Procedure: A Case Report

IJU Case Reports, Volume 8, Issue 6, Page 567-570, November 2025.
ABSTRACT Introduction Priapism is a persistent penile erection lasting > 4 h without sexual stimulation. Ischemic priapism requires urgent management. We report a recurrent ischemic priapism case post‐living‐donor kidney transplantation necessitating multiple interventions, including bilateral T‐shunt procedures.
Hiroto Kishino, Toru Sugihara, Takuya Iwaki, Sho Nishida, Kyoko Minamisono, Takehiro Oyama, Satoshi Ando, Kimihiko Moriya, Daiki Iwami, Tetsuya Fujimura   +9 more
wiley   +1 more source

Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]

, 2019
Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J., Hafen, Paul S., Miller, Spencer G.   +2 more
core   +1 more source