Results 91 to 100 of about 180,670 (278)

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

The intestinal carrier status of Enterococcus spp. in children: clonal diversity and alterations in resistance phenotypes before and after admission to a pediatric intensive care unit

BMC Pediatrics, 2023
Background This study aimed to investigate the intestinal carrier status of Enterococcus spp. among children in a pediatric intensive care unit (PICU) and reveal the role of hospitalization in the alteration of resistance phenotypes and clonal diversity ...
Fariba Shirvani, Romina Hassanzadeh, Bahareh Attaran, Ghazale Ghandchi, Nafiseh Abdollahi, Zari Gholinejad, Zahra Sheikhi, Azita Behzad, Fatemeh Fallah, Leila Azimi, Azam Safarkhani, Abdollah Karimi, Alireza Mahdavi, Shahnaz Armin, Roxana Mansour Ghanaiee, Sedigheh Rafiei Tabatabaei, Seyed Alireza Fahimzad, Masoud Alebouyeh   +17 more
doaj   +1 more source

Pneumococcal antibody concentrations and carriage of pneumococci more than 3 years after infant immunization with a pneumococcal conjugate vaccine. [PDF]

, 2012
BACKGROUND: A 9-valent pneumococcal conjugate vaccine (PCV-9), given in a 3-dose schedule, protected Gambian children against pneumococcal disease and reduced nasopharyngeal carriage of pneumococci of vaccine serotypes.
Greenwood, Brian M, Godwin C. Enwere, Brown J Okoko, Nsekpong, Ekpedeme D, Godwin C Enwere, Ekpedeme D Nsekpong, Syed M. A. Zaman, Aderonke A. Odutola, Saaka, Mark, Zaman, Syed MA, Akinsola, Adebayo K, Richard A. Adegbola, Syed M A Zaman, Adebayo K. Akinsola, Aderonke A Odutola, Richard A Adegbola, Martin O. C. Ota, Okoko, Brown J, Odutola, Aderonke A, Martin O C Ota, Cutts, Felicity T, Felicity T Cutts, Ekpedeme D. Nsekpong, Felicity T. Cutts, Adebayo K Akinsola, Brown J. Okoko, Enwere, Godwin C, Brian M Greenwood, Mark Saaka, Adegbola, Richard A, Brian M. Greenwood, Ota, Martin OC   +31 more
core   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Fecal and Salivary Cortisol Concentrations in Woolly (Lagothrix ssp.) and Spider Monkeys (Ateles spp.) [PDF]

, 2009
Detrimental physiological effects due to stressors can contribute to the low captive success of primates. The objective of this research was to investigate the potential impact of diet composition on cortisol concentrations in feces and saliva in woolly (
Heugten, E., van, Scott Whisnant, van Heugten, E., Whisnant, S., Swarts, H.J.M., Kimberly D. Ange-van Heugten, Ange-van Heugten, K.D., Peter Ferket, Saskia Timmer, Abahor Elias, Timmer, S., Bosch, G., Verstegen, M.W.A., Martin W. A. Verstegen, Guido Bosch, Elias, A., Hans J. M. Swarts, Eric van Heugten, Ferket, P.   +18 more
core   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

The Extra Load Index as a method for comparing the relative economy of load carriage systems. [PDF]

, 2010
The Extra Load Index (ELI) has been proposed as a suitable method of assessing the relative economy of load carriage systems. The purpose of this study was to determine, based on empirical evidence, that the ELI can accommodate variations in both body ...
Carlton Cooke, Ray Lloyd, Hind, K, Cooke, CB, Parr, B, Davies, S, Bridget Parr, Simeon Davies, Hind, Karen, Davies, Simeon E.H., Davies, Simeon, Karen Hind, Parr, Bridget, Cooke, Carlton, Parr, Bridget M, Cooke, Carlton Brian, Lloyd, Ray, Lloyd, R   +17 more
core   +1 more source

Risk factors for ESBL fecal carriage among under five years children.

, 2021
Risk factors for ESBL fecal carriage among under five years children.
Kassu Desta Tullu (9635771), Yonas Mekonnen Gebeyehu (11512950), Negga Asamene Abera (11512947), Surafel Fentaw Dinku (11512953), Mekdes Alemu Tola (11512944)   +4 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source