Results 81 to 90 of about 19,361 (284)

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

The intestinal carrier status of Enterococcus spp. in children: clonal diversity and alterations in resistance phenotypes before and after admission to a pediatric intensive care unit

BMC Pediatrics, 2023
Background This study aimed to investigate the intestinal carrier status of Enterococcus spp. among children in a pediatric intensive care unit (PICU) and reveal the role of hospitalization in the alteration of resistance phenotypes and clonal diversity ...
Fariba Shirvani, Romina Hassanzadeh, Bahareh Attaran, Ghazale Ghandchi, Nafiseh Abdollahi, Zari Gholinejad, Zahra Sheikhi, Azita Behzad, Fatemeh Fallah, Leila Azimi, Azam Safarkhani, Abdollah Karimi, Alireza Mahdavi, Shahnaz Armin, Roxana Mansour Ghanaiee, Sedigheh Rafiei Tabatabaei, Seyed Alireza Fahimzad, Masoud Alebouyeh   +17 more
doaj   +1 more source

Resistance decay in individuals after antibiotic exposure in primary care: A systematic review and meta-analysis [PDF]

, 2012
Background Antibiotic resistance is an urgent global problem, but reversibility is poorly understood. We examined the development and decay of bacterial resistance in community patients after antibiotic use.
Bakhit, Mina, Hoffmann, Tammy, Scott, Anna Mae, Beller, Elaine, Rathbone, John, Del Mar, Chris   +5 more
core   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Faecal carriage of antibiotic resistant Escherichia coli in asymptomatic children and associations with primary care antibiotic prescribing: a systematic review and meta-analysis [PDF]

, 2016
Background The faecal reservoir provides optimal conditions for the transmission of resistance genes within and between bacterial species. As key transmitters of infection within communities, children are likely important contributors to endemic ...
Bryce, A, Costelloe, C, Hawcroft, C, Hay, AD, Wootton, M   +4 more
core   +3 more sources

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Intestinal carriage of Staphylococcus aureus: How does its frequency compare with that of nasal carriage and what is its clinical impact? [PDF]

, 2008
The bacterial species Staphylococcus aureus, including its methicillin-resistant variant (MRSA), finds its primary ecological niche in the human nose, but is also able to colonize the intestines and the perineal region.
A Bhalla, A Borer, A Gravet, A Rosenthal, A Semic-Jusufagic, A Solis, A. van Belkum, AC Lundell, AE Simor, AH Suggs, AJ Ray, B Bjorksten, B Bjorksten, C Dupeyron, C Dupeyron, C Squier, CO Solberg, CO Solberg, D Rimland, D. S. Acton, DC Lee, DK Warren, E Cerda, E Lindberg, E Lindberg, EB Gustafsson, EJ Bishop, FA Manian, G Ackermann, G Kampf, G Metan, G Papia, GD Aeilts, H Bisgaard, H Masaki, HE Larson, HF Wertheim, HF Wertheim, HJ Weinstein, I Adlerberth, I Grmek-Kosnik, IC Michelow, J Boe, J Brodie, J Kluytmans, JM Boyce, JM Boyce, JM Mylotte, JP Furuno, JQ Matthias, K Crossley, K Flemming, K Maeder, K Singh, K Thorburn, KC Carroll, KK Gnanalingham, KT Chen, KT Chen, L Grun, L Mody, L Silvestri, LG Tulloch, M Buehlmann, M Eveillard, M Kalliomaki, M Klotz, M Ridley, M. J. Tempelmans Plat-Sinnige, MA Cal de la, MC Roghmann, ME Falagas, ME Falagas, MK Froberg, MM Rijen Van, MO Efuntoye, MS Lim, N Singh, N. de Groot, NJ Asha, O Meurman, R Buttiaux, R Coello, R Darouiche, R Hare, R Shahin, RC Reyes, RE Williams, RM Greendyke, S Harbarth, S Polakoff, S Roberts, SC Numan, SJ Dancer, SJ Drews, SJ Hal Van, SM Cavalcanti, SX Zhang, T Hofstad, TM Perl, W. van Wamel, WE Trick, YL Lee   +102 more
core   +3 more sources

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source