Results 11 to 20 of about 75,010 (260)
SoftwareXThis paper describes an open-source computational tool developed for the modeling and simulation of fed-batch bioreactors, particularly for processes employing Chinese Hamster Ovary (CHO) cells, which are integral to biopharmaceutical manufacturing.
Tilen Gimpelj, Aleksandar Tošić
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Repetitive Fed-Batch: A Promising Process Mode for Biomanufacturing With E. coli
Frontiers in Bioengineering and Biotechnology, 2020 Recombinant protein production with Escherichia coli is usually carried out in fed-batch mode in industry. As set-up and cleaning of equipment are time- and cost-intensive, it would be economically and environmentally favorable to reduce the number of ...
Julian Kopp +5 more
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The scale-up of microbial batch and fed-batch fermentation processes [PDF]
Journal of Biotechnology, 2007 Publisher Summary The scale-up of single-celled aerobic microbial fermentation processes is complicated that can lead to unpredictable process performance. However, this is not due to the introduction of fluid dynamic generated stresses (or so-called “shear damage”), whether arising from agitator generated turbulence or bursting bubbles, rather it is
Christopher J, Hewitt, Alvin W, Nienow
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Microbial Cell Factories, 2022 Background Fed-batch mode is the standard culture technology for industrial bioprocesses. Nevertheless, most of the early-stage cell and process development is carried out in batch cultures, which can bias the initial selection of expression systems ...
Daniela Velazquez +5 more
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Egyptian Journal of Biological Pest Control, 2020 The effect of batch and fed-batch fermentation on the cultivation performance of Bacillus thuringiensis was investigated using a 5-l stirred tank bioreactor.
Mohamed Mazmira Mohd Masri +1 more
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International Journal of Renewable Energy Development, 2013 Nowadays reserve of fossil fuel has gradually depleted. This condition forces many researchers to find energy alternatives which is renewable and sustainable in the future.
H Hadiyanto +3 more
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Optimization Feed Composition on Hyaluronic Acid Production of in-Batch and Fed-Batch Cultures of Streptococcus zooepidemicus [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 Hyaluronic acid (HA), as a high-value-added biological product, is one of the most widely used biopolymers in industry and medicine. This study aimed to increase HA production by carefully investigating the effect of glucose concentration, type and ...
Saeed Saharkhiz, Valiollah Babaeipour
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Fermentation, 2023 Steam explosion pretreatment is suitable for bioethanol production from Eucalyptus globulus wood. Multifactorial experiment designs were used to find the optimal temperature and residence time required to obtain the best glucose yield from the enzymatic ...
Eduardo Troncoso-Ortega +5 more
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Journal of Biological Engineering, 2019 Background Fed-batch conditions are advantageous for industrial cultivations as they avoid unfavorable phenomena appearing in batch cultivations. Those are for example the formation of overflow metabolites, catabolite repression, oxygen limitation or ...
T. Keil +4 more
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Model Predictive Control—A Stand Out among Competitors for Fed-Batch Fermentation Improvement
Fermentation, 2023 The fed-batch cultivation is in many ways a benchmark for fermentation processes, and it has been an attractive choice for the biotechnological production of various products in the past decades.
Emils Bolmanis +3 more
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