Results 31 to 40 of about 172,886 (267)

Ameliorative effects of lycopene on oxidized fish oil-induced growth reduction and hepatic oxidative alterations of Jinhu grouper (Epinephelus fuscoguttatus ♀ × Epinephelus tukula ♂)

Aquaculture Reports
This study investigated the effects of adding lycopene to oxidized fish oil diets on the growth and liver health in Jinhu grouper (Epinephelus fuscoguttatus ♀ × Epinephelus tukula ♂).
Guoyong Huang, Weibin Huang, Guangcai Fu, Hengyang Song, Wenshan Cai, Yubin Liu, Yuxuan Han, Yilin Yao, Beiping Tan, Xiaohui Dong   +9 more
doaj   +1 more source

Squalene activates Wnt/β-Catenin signaling pathway to mediate NF-κB pathway to regulate inflammatory response and disease resistance in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)

Aquaculture Reports, 2023
We previously found that squalene may influence immunity of grouper by affecting the Wnt/β-Catenin signaling pathway, but the exact mechanism is uncertain.
Xiaobo Yan, Simiao Pan, Tao Li, Weibin Huang, Menglong Zhou, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effects of Soluble and Insoluble Non-Starch Polysaccharides on Growth Performance, Digestive Enzyme Activity, Antioxidant Capacity, and Intestinal Flora of Juvenile Genetic of Improvement of Farmed Tilapia (Oreochromis niloticus)

Frontiers in Marine Science, 2022
This study aimed to evaluate the effects of soluble and insoluble non-starch polysaccharides (NSPs) on growth performance, digestive enzyme activity, antioxidant capacity, and intestinal flora of juvenile GIFT tilapia (Oreochromis niloticus).
Yu Liu, Yu Liu, Yu Liu, Junming Deng, Junming Deng, Junming Deng, Beiping Tan, Beiping Tan, Beiping Tan, Shiwei Xie, Shiwei Xie, Shiwei Xie, Wei Zhang, Wei Zhang, Wei Zhang   +14 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The positive impacts of tea polyphenols on the growth performance, immune responses, and hepatic health of largemouth bass (Micropterus salmoides) under high fat diets

Aquaculture Reports
The objective of this study was to assess the impacts of tea polyphenols (TP) on the growth performance, immune responses, and hepatic health of largemouth bass (M. salmoides) under high fat diets. A total of 375 individuals (average initial weight: 34 ± 
Digen Qin, Jiale Chen, Junxiong Li, Zhiyou Liu, Weibin Huang, Hao Liu, Hengyang Song, Wenshan Cai, Beiping Tan, Xiaohui Dong   +9 more
doaj   +1 more source

Feeding juvenile largemouth bass (Micropterus salmoides) with carboxymethyl cellulose with different viscous: Impacts on nutrient digestibility, growth, and hepatic and gut morphology

Frontiers in Marine Science, 2022
A 56-day trial investigated the impact of the dietary inclusion of cellulose with different viscosities on the growth, nutrient digestibility, serum biochemical indices, and the hepatic and gut morphology of largemouth bass juveniles.
Yu Liu, Yu Liu, Yu Liu, Jiongting Fan, Jiongting Fan, Jiongting Fan, Hang Zhou, Hang Zhou, Hang Zhou, Yumeng Zhang, Yumeng Zhang, Yumeng Zhang, Huajing Huang, Huajing Huang, Huajing Huang, Yixiong Cao, Yixiong Cao, Yixiong Cao, Wei Zhang, Wei Zhang, Wei Zhang, Junming Deng, Junming Deng, Junming Deng, Beiping Tan, Beiping Tan, Beiping Tan   +26 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effects of dietary n-3HUFA levels on growth, antioxidant capacity, and ovarian development in Litopenaeus vannamei broodstock shrimp

Aquaculture Reports
The present study investigated the effects of dietary n-3 highly unsaturated fatty acids (n-3 HUFA) on the growth, antioxidant capacity, and ovarian development of female Litopenaeus vannamei broodstock. Five experimental diets with varying levels of n-3
Weibin Huang, Biao Li, Beiping Tan, Digen Qin, Zhiyue Li, Xintong Su, Yansheng Liu, Shuang Zhang, Shiwei Xie, Xiaohui Dong   +9 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source