Results 51 to 60 of about 1,017,606 (300)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Effects of feed intake-regulated nutritional compensation strategies on growth performance, blood indices, and rumen microbiota of Gangba sheep

open access: yesAnimal Nutrition
Feed intake-regulated nutritional compensation improves feed efficiency in sheep; however, its relevance and underlying mechanisms in high-altitude indigenous breeds such as Gangba sheep remain unclear. Ninety-six four-month-old healthy male Gangba sheep
Yining Xie   +4 more
doaj   +1 more source

Productive performance, body chemical composition, and deposition of 42-day-old quail for meat subjected to quantitative dietary restriction

open access: yesSemina: Ciências Agrárias, 2017
This study aimed to assess the effect of quantitative dietary restriction during refeeding on the performance, body chemical composition, and deposition, weight gain of organs and carcass parts of quails reared for meat (Coturnix coturnix coturnix).
Daiane de Oliveira Grieser   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Penambahan Kromium Organik pada Pakan Yang Dibatasi Terhadap Performa Produksi Puyuh

open access: yesJurnal Ilmu Peternakan Terapan, 2018
The aim of this research was to know the effect of organic chromium on feed which was limited to quail phase pre-layer production performance. The experimental design of the study was a Completely Randomized Design (CRD) consisting of twelve treatments ...
Ujang Suryadi   +2 more
doaj  

Investigate the Effect of Commercial Strain Type and Feeding Methods on Performance, Intestinal Morphological Parameters, and Immune System of Broiler Chickens [PDF]

open access: yesپژوهشهای علوم دامی ایران
Introduction: The feed restriction program is one of the main techniques in growth curve manipulation for increasing production efficiency in broiler chicken .Quantities and qualitative feed restriction are procedures that can be used to manipulate the ...
Hesamuddin Zahabi   +5 more
doaj   +1 more source

Effect of feed restriction on performance and feed digestibility in rabbits

open access: yesItalian Journal of Animal Science, 2007
Two hundred and fifty-six Hyla rabbits were equally divided into two groups fed the same commercial concentrates supplied ad libitum (group AL) or restricted to 90 % of ad libitum (group RES) from weaning (35 d) to slaughter (85 d). Mortality was recorded daily. On 20 rabbits per group feed intake and live weight were recorded, respectively, on a daily
DI MEO, CARMELO   +4 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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