Results 21 to 30 of about 5,495 (171)

SD inhibition by fenfluramine

, 2023
This study characterized SD inhibitory properties of fenfluramine, a serotonin releasing agent, using in vitro SD assays. Our results suggest that fenfluramine can inhibit SD independent of the serotonin system.
Isamu Aiba (14339775)
core   +1 more source

Efficacy and safety of adjunctive antiseizure medications for dravet syndrome: A systematic review and network meta-analysis

Frontiers in Pharmacology, 2022
Purpose: Recently, the U.S. Food and Drug Administration (FDA) approved stiripentol, cannabidiol, and fenfluramine to treat patients with Dravet syndrome (DS). Moreover, soticlestat was determined as a promising new drug for the treatment of DS as it has
Jianhua Wu, Liu Zhang, Xi Zhou, Jiajun Wang, Xiangyi Zheng, Hankun Hu, Dongfang Wu   +6 more
doaj   +1 more source

In vivo incorporation of fenfluramine and norfenfluramine into pigmented and nonpigmented hair of rats measured by HPLC-fluorescence detection [PDF]

, 2010
The incorporation profiles for fenfluramine (Fen) and its metabolite norfenfluramine (Norf) into black hair and white hair of Zucker rats and into white hair of Wistar rats after intraperitoneal (i.p.) administration of Fen or N-nitrosofenfluramine (N ...
Wada, Mitsuhiro, Nakashima, Kenichiro, Amal Kaddoumi, Kenichiro Nakashima, Mitsuhiro Wada, Kaddoumi, Amal   +5 more
core   +1 more source

Fenfluramine for seizures associated with Sunflower syndrome

, 2021
AIM: To determine the efficacy of fenfluramine on seizure frequency in patients with Sunflower syndrome. Secondary endpoints were changes in electroencephalogram (EEG) characteristics, cognitive functioning, executive functioning, and quality of life ...
Amy Morgan, Falk, Amy, Samarth P Doshi, Elizabeth A Thiele, Thiele, Elizabeth A., Patel, Sandip, Patricia L Bruno, Doshi, Samarth P., Jo Sourbron, Sourbron, Jo, Morgan, Amy, Sandip Patel, Bruno, Patricia L., Kennedy R Geenen, Vu, Uyen, Amy Falk, Uyen Vu, Geenen, Kennedy R.   +17 more
core   +1 more source

SCN1B Genetic Variants: A Review of the Spectrum of Clinical Phenotypes and a Report of Early Myoclonic Encephalopathy

Children, 2022
Background: Pathogenic variants in SCN1B, the gene encoding voltage-gated sodium channel b1/b1B subunits are associated with a spectrum of epileptic disorders.
Zahra Zhu, Elizabeth Bolt, Kyra Newmaster, Wendy Osei-Bonsu, Stacey Cohen, Vishnu Anand Cuddapah, Siddharth Gupta, Sita Paudel, Debopam Samanta, Louis T. Dang, Paul R. Carney, Sunil Naik   +11 more
doaj   +1 more source

Fenfluramine's Broader Potential: A Second Notable Electroencephalogram Response in Developmental Epileptic Encephalopathy With Spike‐Wave Activation in Sleep [PDF]

Annals of the Child Neurology Society
Abigail Arroyo, Douglas R. Nordli III, Fernando Galan   +2 more
doaj   +2 more sources

The Pharmacoresistant Epilepsy: An Overview on Existent and New Emerging Therapies

Frontiers in Neurology, 2021
Epilepsy is one of the most common neurological chronic disorders, with an estimated prevalence of 0. 5 – 1%. Currently, treatment options for epilepsy are predominantly based on the administration of symptomatic therapy.
Antonella Fattorusso, Sara Matricardi, Elisabetta Mencaroni, Giovanni Battista Dell'Isola, Giuseppe Di Cara, Pasquale Striano, Pasquale Striano, Alberto Verrotti   +7 more
doaj   +1 more source

An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European Early Access Program

Epilepsia Open, 2022
Objective To examine the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) in three age groups:
Renzo Guerrini, Nicola Specchio, Ángel Aledo‐Serrano, Milka Pringsheim, Francesca Darra, Thomas Mayer, Antonio Gil‐Nagel, Tilman Polster, Sameer M. Zuberi, Amélie Lothe, Arnold Gammaitoni, Adam Strzelczyk   +11 more
doaj   +1 more source

Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex

eLife, 2021
Serotonin (5-HT) is one of the major neuromodulators present in the mammalian brain and has been shown to play a role in multiple physiological processes.
Roberto de Filippo, Benjamin R Rost, Alexander Stumpf, Claire Cooper, John J Tukker, Christoph Harms, Prateep Beed, Dietmar Schmitz   +7 more
doaj   +1 more source

Low-dose fenfluramine in the treatment of neurologic disorders: experience in Dravet syndrome

Therapeutic Advances in Neurological Disorders, 2015
In this paper, we review the experience with fenfluramine in epileptic and other paroxysmal disorders. Since the best available data are from the treatment of Dravet syndrome, we will focus primarily on this condition.
An-Sofie Schoonjans, Lieven Lagae, Berten Ceulemans   +2 more
doaj   +1 more source