Results 41 to 50 of about 5,495 (171)

Cardiovascular and autonomic effects of fenfluramine hydrochloride

, 1965
Fenfluramine hydrochloride (N-ethyl-α-methyl-3-trifluoromethylphenethylamine hydrochloride; AHR-965) administered orally or intravenously to anaesthetised or unanaesthetised dogs, caused a predominant rise in arterial blood pressure, tachycardia, an ...
John W Ward, Bernard V Franko, Leroy J Honkomp   +2 more
core   +1 more source

A critical evaluation of fenfluramine hydrochloride for the treatment of Dravet syndrome

, 2022
: Introduction: Dravet Syndrome (DS) is a severe developmental and epileptic encephalopathy. Fenfluramine recently demonstrated to be a highly efficacious and safe treatment option for DS patients.
Ceulemans, Berten, Berten Ceulemans, Schoonjans, An-Sofie, An-Sofie Schoonjans   +3 more
core   +1 more source

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

Epileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori, Hiroshi Terashima, Yu kakimoto, Mitsuhiro Kato, Shumpei Uchino   +4 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations

Frontiers in Neuroscience, 2021
IntroductionSerotonin is involved in a variety of physiological functions and brain disorders. In this context, efforts have been made to investigate the in vivo fluctuations of this neurotransmitter using positron emission tomography (PET) imaging ...
Matthieu Colom, Matthieu Colom, Benjamin Vidal, Sylvain Fieux, Jérôme Redoute, Nicolas Costes, Franck Lavenne, Inés Mérida, Zacharie Irace, Thibaud Iecker, Caroline Bouillot, Thierry Billard, Adrian Newman-Tancredi, Luc Zimmer, Luc Zimmer, Luc Zimmer, Luc Zimmer   +16 more
doaj   +1 more source

Prolonged fenfluramine use in open‐label studies of Dravet or Lennox–Gastaut syndromes: Long‐term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness

Epilepsia, EarlyView.
This graphical abstract provides an overview of the content from this open‐label extension study of fenfluramine use in patients with Dravet syndrome or Lennox‐Gastaut syndrome. Abstract Objective Long‐term safety and global functioning are reported in patients with Dravet syndrome (DS) or Lennox–Gastaut syndrome (LGS) treated with fenfluramine in an ...
Antonio Gil‐Nagel, Kelly G. Knupp, Boudewijn Gunning, Domenica Immacolata Battaglia, Elizabeth A. Thiele, Ingrid E. Scheffer, An‐Sofie Schoonjans, Rima Nabbout, Nathalie Villeneuve, Kerstin Alexandra Klotz, Nicola Specchio, Rocio Sanchez‐Carpintero, Marta Zolnowska, Anne‐Liv Schulz, Lily Perrin, Najla Dickson, Mélanie Langlois, Amélie Lothe, Joseph Sullivan   +18 more
wiley   +1 more source

Long-Term Efficacy of Fenfluramine in Treatment of Obesity

, 1983
42 obese women who lost at least 6 kg after 26 weeks on fenfluramine tablets had their treatment changed to either an equivalent dose of a sustained-release preparation of fenfluramine or matching placebo in double-blind fashion.
Gough, J, Gough, J., Frazer, I., Frazer, I, Chalmers, S. R., Preston, P. G., Haslett, C, Haslett, C., Douglas, JG, Munro, JF, Munro, J. F., Douglas, J. G., Preston, PG, Chalmers, SR   +13 more
core   +1 more source

Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo‐controlled clinical trial

, 2023
Objective: This study was undertaken to assess the safety and efficacy of fenfluramine in the treatment of convulsive seizures in patients with Dravet syndrome.Methods: This multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase
Ingrid E. Scheffer, Anupam Agarwal, Polster, Tilman, Ceulemans, Berten, Bradley S. Galer, Devinsky, Orrin, Joseph Sullivan, Michael Lock, Galer, Bradley S, Dinesh Talwar, Arnold R. Gammaitoni, Marina Nikanorova, Gammaitoni, Arnold R, Linda Laux, J. Helen Cross, Talwar, Dinesh, Laux, Linda, FAiRE DS Study Group, Scheffer, Knupp, Kelly G, Lock, Michael, Darra F, Kelly G. Knupp, Tilman Polster, Lieven Lagae, Rima Nabbout, Renzo Guerrini, Berten Ceulemans, Lagae, Lieven, Ingrid E, Guerrini, Renzo, Cross, J Helen, Gail M. Farfel, Agarwal, Anupam, Nabbout, Rima, Nikanorova, Marina, Farfel, Gail M, Orrin Devinsky, Sullivan, Joseph   +38 more
core   +1 more source

Antiseizure medication prescribing in people with Dravet syndrome: An analysis of real‐time administrative data

Epilepsia Open
Since 2018, three new antiseizure medications (ASMs) received FDA approval for Dravet syndrome (DS) in the U.S: cannabidiol, stiripentol, and fenfluramine. Yet, the uptake of these ASMs in routine clinical practice is unknown. We use new ICD‐10 codes for
Kevin Y. Xu, Binx Yezhe Lin, M. Scott Perry, Fábio A. Nascimento   +3 more
doaj   +1 more source

Refining diagnostic boundaries and electroclinical profiles of Lennox–Gastaut syndrome through unsupervised clustering

Epilepsia, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy defined by polymorphic seizures, intellectual disability (ID), and characteristic electroencephalographic (EEG) patterns. The applicability and biological validity of current electroclinical criteria remain debated.
Emanuele Cerulli Irelli, Marco Perulli, Maria S. Borioni, Anna Falco, Adolfo Mazzeo, Enrico Cocchi, Maria L. Gambardella, Alessandra Morano, Michela Quintiliani, Maria Picilli, Anna T. Giallonardo, Carlo Di Bonaventura, Domenica I. Battaglia   +12 more
wiley   +1 more source