Results 31 to 40 of about 12,682 (143)

Fenofibrate Administration Reduces Alcohol and Saccharin Intake in Rats: Possible Effects at Peripheral and Central Levels

Frontiers in Behavioral Neuroscience, 2017
We have previously shown that the administration of fenofibrate to high-drinker UChB rats markedly reduces voluntary ethanol intake. Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist, which induces the proliferation of ...
Mario Rivera-Meza, Daniel Muñoz, Erik Jerez, María E. Quintanilla, Catalina Salinas-Luypaert, Katia Fernandez, Eduardo Karahanian, Eduardo Karahanian   +7 more
doaj   +1 more source

Fenofibrate alleviates insulin resistance by reducing tissue inflammation in obese ovariectomized mice

Nutrition & Diabetes, 2023
Background Fenofibrate is a hypolipidemic peroxisome proliferator-activated receptor α (PPARα) agonist used clinically to reduce hypercholesterolemia and hypertriglyceridemia. Objective We investigated the effects of fenofibrate on insulin resistance and
Jungu Lee, Suyeon Jeon, Mijeong Lee, Michung Yoon   +3 more
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Enantioselective Reductive Alkenylation of α‐CF2H (‐CF3) Amino Halides: Rapid Access to Chiral α‐CF2H (‐CF3) Allylamines

Advanced Science, EarlyView.
Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu, Kuiliang Li, Yan He, Chen‐Hui Jiang, Ruo‐Xing Jin, Duo‐Duo Hu, Wei‐Cheng Zhao, Xuan Nie, Shang‐Zheng Sun, Xi‐Sheng Wang   +9 more
wiley   +1 more source

Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease

Drug Design, Development and Therapy, 2023
Chao Tang,1,2,* Xiaoqing Deng,1,* Jingru Qu,1 Yahui Miao,1 Lei Tian,1 Man Zhang,1 Xiaoyu Li,1 Bei Sun,1 Liming Chen1 1NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital ...
Tang C, Deng X, Qu J, Miao Y, Tian L, Zhang M, Li X, Sun B, Chen L   +8 more
doaj  

Late‐Stage Phenylation From [13C6] and [2H5]Benzene: A Versatile Tool for Stable Isotope Labeled MS Standards

Chemistry – A European Journal, EarlyView.
ABSTRACT We explored aryl thianthrenation as a tool for directly incorporating multiple isotopes into molecular scaffolds starting from full isotopically labeled benzene. Stable isotope‐labeled (SIL) molecules are indispensable tools for investigating chemical and biological mechanisms and quantifying metabolites.
Alexandre Labiche, Bouchaib Mouhsine, Dorian Dupommier, Louise Fogel, Frédéric Robert, David‐Alexandre Buisson, Frédéric Taran, Davide Audisio   +7 more
wiley   +1 more source

Fenofibrate Inhibits Subretinal Fibrosis Through Suppressing TGF‐β—Smad2/3 signaling and Wnt signaling in Neovascular Age‐Related Macular Degeneration

Frontiers in Pharmacology, 2020
Subretinal fibrosis is a common pathological change that causes vision loss in neovascular age-related macular degeneration (nAMD). Treatment modalities for subretinal fibrosis are limited.
Qian Chen, Qian Chen, Nan Jiang, Yuhan Zhang, Sihao Ye, Xu Liang, Xin Wang, Xiang Lin, Rongrong Zong, Haoyu Chen, Zuguo Liu, Zuguo Liu   +11 more
doaj   +1 more source

Efficacy of Pemafibrate in Comparison to Fenofibrate and Bezafibrate on Triglyceride Levels and Liver, and Renal Functions in Patients With Hypertriglyceridemia and Type 2 Diabetes

Tokyo Women's Medical University Journal, 2023
Background: To compare the efficacy and safety of pemafibrate with those of fenofibrate in a real-world setting in patients with hypertriglyceridemia and type 2 diabetes (T2D).
Junko Oya, Tomoko Nakagami, Yuichiro Kondo, Aki Katamine, Mika Shimizu, Yukiko Hasegawa, Tetsuya Babazono   +6 more
doaj   +1 more source

Remote Migratory Reductive Arylation of Unactivated Alkenes Enabled by Electrochemical Nickel Catalysis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
we have developed an electrochemical Ni−H catalyzed arylation coupling method of unactivated alkenes with aryl halides. The method displays broad functional group tolerance and proceeds under very mild conditions. Furthermore, aryl chlorides were also compatible substrates in this catalytic system. This conversion holds significant implications for the
Chao Xu, Ru‐Han A, Xiao‐Feng Wu
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source