Results 11 to 20 of about 81,387 (301)
Prescription analgesic overuse in older adults: Can we mitigate this growing problem?
AGING MEDICINE, Volume 5, Issue 4, Page 294-296, December 2022., 2022 With older adults already on numerous prescription medications to manage their chronic conditions, the addition of pain medications could impose an even greater burden due to dependency issues. We need to understand the use of chronic pain medication, especially opioids, discuss current strategies and gaps, and offer potential solutions to mitigate ...
Sara Kakatkar +2 more
wiley +1 more source
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco +8 more
wiley +1 more source
J‐SUPPORT research policy for oral mucositis associated with cancer treatment
Cancer Medicine, Volume 11, Issue 24, Page 4816-4829, December 2022., 2022 Abstract Background Oral mucositis is one of the main areas of research in supportive and palliative care of cancer patients. However, the methodology of prospective clinical trials on oral mucositis has not been established, despite its uniqueness.
Tomoya Yokota +7 more
wiley +1 more source
Dose of intra‐operative opioids has no impact on recurrence or survival in primary liver cancer
Cancer Medicine, Volume 11, Issue 24, Page 4927-4934, December 2022., 2022 Kaplan‐meier curves for recurrence‐free and overall survial of high‐dose and low‐dose groups. No significant difference in recurrence‐free survial (A) or overall survial (B) after surgery was noted when comparing high‐dose with low‐dose groups. Abstract Background Intra‐operative use of opioid analgesics might have an impact on cancer recurrence and ...
Liuyuan Zhao +9 more
wiley +1 more source
Bone construction surgery: A case report using recombinant human platelet‐derived growth factor‐BB
Clinical Advances in Periodontics, Volume 12, Issue 4, Page 262-269, December 2022., 2022 Abstract Background The position and condition of bone largely sets the stage for functional and esthetic implant success. In bone construction surgery, creating a sustainable functional matrix is complex, but necessary, to enable long‐term mechanotransduction and maintenance of soft tissue support.
George A. Mandelaris, Bradley DeGroot
wiley +1 more source
Prompt Engineering for Transformer-based Chemical Similarity Search Identifies Structurally Distinct Functional Analogues [PDF]
, 2023 Chemical similarity searches are widely used in-silico methods for identifying new drug-like molecules. These methods have historically relied on structure-based comparisons to compute molecular similarity. Here, we use a chemical language model to create a vector-based chemical search.
arxiv +1 more source
Development of a New Method Based on Copper Sulfide Nanoparticles for the Determination of Fentanyl in Biological Samples [PDF]
ImmunoAnalysis, 2022 Background: Fentanyl is an opioid analgesic drug extensively used to alleviate pain with no consciousness loss. To address the fentanyl crisis from the criminal and medical perspectives,the development of a free drug determination methodology for this ...
Sedigheh Mohammadzadeh, Zahra Karimzadeh
doaj +1 more source
Infectious Diseases and Therapy, 2023 Introduction An unsafe injection practice is one of the major contributors to new hepatitis C virus (HCV) infections; thus, people who inject drugs are a key population to prioritize to achieve HCV elimination.
Dwaipayan Mukherjee +8 more
doaj +1 more source
Journal of Pain and Symptom Management, 2005 Fentanyl, a potent lipid-soluble opioid which was first synthesized more than 40 years ago, is still the most popular opioid used in the perioperative period throughout the world. Fentanyl's introduction, versatility, and popularity have resulted in its use in many acute and chronic pain conditions and a multitude of novel delivery systems in the last ...
openaire +2 more sources
Taiwanese Journal of Obstetrics & Gynecology, 2011 Objective: Pain affects many cancer patients in advancing stages, lowering the level of their quality of life. Morphine has long been the “gold standard” for the treatment of cancer pain; however, its side effects, particularly sedation and cognitive ...
Chiharu Kanamori +3 more
doaj +1 more source