Results 11 to 20 of about 195,889 (397)

Oral transmucosal fentanyl [PDF]

Anaesthesia, 1998
None ...
D. Prosser, M. Allman, Paul Grassby
openaire   +6 more sources

Charting the Fourth Wave: Geographic, Temporal, Race/Ethnicity, and Demographic Trends in Polysubstance Fentanyl Overdose Deaths in the United States, 2010-2021

medRxiv, 2022
Aims: To characterize polysubstance death in the United States during the transition to the fourth wave of the overdose crisis. To characterize co-involved substances in fatal overdose involving synthetic opioids (mainly illicitly manufactured fentanyl ...
Joseph R. Friedman, Chelsea L. Shover
semanticscholar   +1 more source

Fentanyl Absorption, Distribution, Metabolism, and Excretion: Narrative Review and Clinical Significance Related to Illicitly Manufactured Fentanyl

Journal of addiction medicine, 2023
Objectives This narrative review summarizes literature on pharmaceutical fentanyl's absorption, distribution, metabolism, and excretion patterns to inform research on illicitly manufactured fentanyl (IMF).
PharmD H. Elizabeth Bird, P. M. Andrew S. Huhn, P. M. Kelly E. Dunn   +2 more
semanticscholar   +1 more source

Increasing presence of xylazine in heroin and/or fentanyl deaths, Philadelphia, Pennsylvania, 2010–2019

Injury Prevention, 2021
Reports from active drug users state that xylazine, the veterinary tranquilliser, has been increasing in the illicit drug supply in Philadelphia. To describe trends and characteristics of unintentional deaths from heroin and/or fentanyl overdose with ...
Jewell Johnson, L. Pizzicato, Caroline C. Johnson, Kendra M. Viner   +3 more
semanticscholar   +1 more source

Sex- and Dose-Dependent Differences in the Development of an Addiction-Like Phenotype Following Extended-Access Fentanyl Self-Administration

Frontiers in Pharmacology, 2022
Opioid use disorder (OUD) is a major epidemic in the United States, and fentanyl is a major culprit. The National Institute on Drug Abuse has highlighted an urgent need for research on the risks and outcomes of OUD with fentanyl; a better understanding ...
E. B. Towers, Ben Setaro, W. J. Lynch
semanticscholar   +1 more source

Evidence of Buprenorphine-precipitated Withdrawal in Persons Who Use Fentanyl

Journal of addiction medicine, 2021
Objectives Buprenorphine can precipitate withdrawal in opioid-dependent persons with recent fentanyl use. However, the prevalence of this phenomenon is not clinically established.
Neil B. Varshneya, A. Thakrar, J. Hobelmann, K. Dunn, A. Huhn   +4 more
semanticscholar   +1 more source

The anomalous pharmacology of fentanyl

British Journal of Pharmacology, 2021
Fentanyl is a key therapeutic, used in anaesthesia and pain management. It is also increasingly used illicitly and is responsible for a large and growing number of opioid overdose deaths, especially in North America.
E. Kelly, K. Sutcliffe, Damiana Cavallo, Nokomis Ramos-Gonzalez, Norah Alhosan, Graeme Henderson   +5 more
semanticscholar   +1 more source

Challenges with buprenorphine inductions in the context of the fentanyl overdose crisis: A case series.

Drug and Alcohol Review, 2021
INTRODUCTION AND AIMS North America is currently experiencing an epidemic of opioid overdose deaths, driven by the proliferation of fentanyl in the street drug market.
Daniel Shearer, Samantha Young, N. Fairbairn, R. Brar   +3 more
semanticscholar   +1 more source

Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain: Design and Rationale of a Randomized Controlled Trial

Prehospital Emergency Care, 2020
Objective: Acute pain management is fundamental in prehospital trauma care. Early pain control may decrease the risk of developing post-traumatic stress disorder (PTSD) and chronic pain. Fentanyl and ketamine are frequently used off-label, but there is a
Jason McMullan, Christopher Droege, Richard Strilka, Kimberly Hart, Christopher Lindsell   +4 more
semanticscholar   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source