Results 31 to 40 of about 81,387 (301)

Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice

Scientific Reports, 2023
The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention.
Michael Leonardo, Sarah Brunty, Jessica Huffman, Alexis Kastigar, Price E. Dickson   +4 more
doaj   +1 more source

Dose- and Sex-Dependent Bidirectional Relationship between Intravenous Fentanyl Self-Administration and Gut Microbiota

Microorganisms, 2022
Gut bacteria influence neural circuits in addiction-related behaviors. Given the association between opioid use, gastrointestinal distress, and microbial dysbiosis in humans and mice, we test the hypothesis that interactions between gut bacteria and the ...
Michelle Ren, Shahrdad Lotfipour
doaj   +1 more source

“It's my frenemy”: A qualitative exploration of knowledge and perceptions of fentanyl use during the COVID-19 pandemic in people who use drugs at a syringe services program in Philadelphia, PA

Frontiers in Public Health, 2022
BackgroundExacerbated by the COVID-19 pandemic and the proliferation of fentanyl and fentanyl analogs, overdose deaths have surged in the United States, making it important to understand how individuals who use drugs experience and perceive the risks of ...
Sarah Bauerle Bass, Sarah Bauerle Bass, Patrick J. A. Kelly, Sphoorti Pandit-Kerr, Jenine Pilla, Katherine Morris, Erin Larsen, Jennifer P. Wisdom, Phillip R. Torralva   +8 more
doaj   +1 more source

Fibrosis imaging with multiparametric proton and sodium MRI in pig injury models

NMR in Biomedicine, Volume 36, Issue 2, February 2023., 2023
Multiparametric MRI can predict intrarenal fibrosis. ADC cortex, ΔR2*, ΔT1, the 23Na medulla/cortex ratio, and plasma creatinine resulted in the most robust model for intrarenal fibrosis prediction. Abstract Chronic kidney disease (CKD) is common and has huge implications for health and mortality.
Camilla W. Rasmussen, Nikolaj Bøgh, Sabrina K. Bech, Thomas H. Thorsen, Esben S. S. Hansen, Lotte B. Bertelsen, Christoffer Laustsen   +6 more
wiley   +1 more source

“It wasn’t here, and now it is. It’s everywhere": fentanyl’s rising presence in Oregon’s drug supply

Harm Reduction Journal, 2022
Background Illicit fentanyl has contributed to a drastic increase in overdose drug deaths. While fentanyl has subsumed the drug supply in the Northeastern and Midwestern USA, it has more recently reached the Western USA.
Sarah S. Shin, Kate LaForge, Erin Stack, Justine Pope, Gillian Leichtling, Jessica E. Larsen, Judith M. Leahy, Andrew Seaman, Daniel Hoover, Laura Chisholm, Christopher Blazes, Robin Baker, Mikaela Byers, Katie Branson, P. Todd Korthuis   +14 more
doaj   +1 more source

Understanding the factors driving the opioid epidemic using machine learning [PDF]

arXiv, 2021
In recent years, the US has experienced an opioid epidemic with an unprecedented number of drugs overdose deaths. Research finds such overdose deaths are linked to neighborhood-level traits, thus providing opportunity to identify effective interventions.
arxiv  

Factors associated with strong opioid use for noncancer pain in patients with chronic intestinal failure

Nutrition in Clinical Practice, Volume 38, Issue 1, Page 129-137, February 2023., 2023
Abstract Background Chronic analgesic use is described in home parenteral nutrition (HPN)–dependent patients, but there are limited data on factors associated with opioid use for noncancerous pain. Methods Patients attending a national UK intestinal failure reference center were divided in two groups according to strong opioid (SO) usage; risk factors ...
Liat Deutsch, Anabelle Cloutier, Gavin Leahy, Antje Teubner, Arun Abraham, Michael Taylor, Peter Paine, Simon Lal   +7 more
wiley   +1 more source

Effects of chronic fentanyl administration on behavioral characteristics of mice

Neuropsychopharmacology Reports, 2019
Background Fentanyl, a synthetic opioid categorized as a narcotic analgesic, has a 100‐ to 200‐fold stronger effect than most opioids, such as morphine. Fatal accidents due to chronic use and abuse of fentanyl are a worldwide social problem.
Kazuki Fujii, Yumie Koshidaka, Mayumi Adachi, Keizo Takao   +3 more
doaj   +1 more source

Higher doses of naloxone are needed in the synthetic opioid era

Substance Abuse Treatment, Prevention, and Policy, 2019
There has been a dramatic increase of deaths due to illicit fentanyl. We examined the pharmacology of fentanyl and reviewed data on the number of repeat doses of naloxone used to treat fentanyl overdoses.
Ronald B. Moss, Dennis J. Carlo
doaj   +1 more source

Virtual reality mobility for burn patients (VR‐MOBILE): A within‐subject‐controlled trial protocol

Paediatric and Neonatal Pain, Volume 4, Issue 4, Page 192-198, December 2022., 2022
Abstract In the acute phase, burn patients undergo several painful procedures. Pediatric burn care procedures conducted in hydrotherapy have been known to generate severe pain intensity and moderate to high levels of anxiety. Hydrotherapy treatments are done with the use of opioids and benzodiazepines for pain and anxiety.
Sylvie Le May, Christine Genest, Maxime Francoeur, Nicole Hung, Estelle Guingo, Christelle Khadra, Melanie Noel, Julie Paquette, Andrée‐Anne Roy   +8 more
wiley   +1 more source