Results 51 to 60 of about 86,514 (304)

Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl

Frontiers in Pharmacology, 2021
Fentanyl is a high-potency opioid receptor agonist that elicits profound analgesia and suppression of breathing in humans and animals. To date, there is limited evidence as to whether changes in oxidant stress are important factors in any of the actions ...
Santhosh Baby, Ryan Gruber, Joseph Discala, Veljko Puskovic, Nijo Jose, Feixiong Cheng, Michael Jenkins, Michael Jenkins, James Seckler, Stephen Lewis   +9 more
doaj   +1 more source

Spatial Concentration of Opioid Overdose Deaths in Indianapolis: An Application of the Law of Crime Concentration at Place to a Public Health Epidemic [PDF]

, 2019
The law of crime concentration at place has become a criminological axiom and the foundation for one of the strongest evidence-based policing strategies to date.
Carter, Jeremy G., Mohler, George, Ray, Bradley   +2 more
core   +1 more source

Criminal legal penalties, substance use, and overdose: a concept mapping study examining Colorado’s criminal legal penalties

BMC Global and Public Health
Background In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk.
Katherine LeMasters, Samantha K. Nall, Cole Jurecka, Betsy Craft, Paul J. Christine, Ryan Goodman, Jessie Henderson, Robert Haywood-James, Angela Williams, Grace Wittner, Joshua A. Barocas   +10 more
doaj   +1 more source

Naphthalimide Derivatives as Film‐Based Fluorescent Sensors for Rapid Detection of Illicit Drugs

Advanced Sensor Research, EarlyView.
Four novel 1,8‐naphthalimide (NI) derivatives for the detection of illicit drugs with different substituents at the 4‐position are reported. Their contrasting fluorescence responses enables five illicit drugs to be distinguished from interferents with a mean classification accuracy of 81%.
Ming Chen, Harrison Stitt, Ronan Chu, Jos C. M. Kistemaker, Ian A. Wood, Paul L. Burn, Ian R. Gentle, Paul E. Shaw   +7 more
wiley   +1 more source

Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle

Addiction Neuroscience
The orexin system plays a major role in drug reward. Orexin-1 receptor (OxR1) blockade reduces fentanyl demand in males. However, there are a number of sex differences in the orexin system, and it is unclear how OxR1 antagonism would decrease fentanyl ...
David De Sa Nogueira, Chuhyon Corwin, Yogesh Rakholia, Varnitha Punnuru, Meghana Nampally, Amy S. Kohtz, Gary Aston-Jones   +6 more
doaj   +1 more source

Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors? [PDF]

, 2015
© 2015, BMJ Publishing Group. All rights reserved. Objectives: Opioids modulate the perception of breathlessness with a considerable variation in response, with poor correlation between the required opioid dose and symptom severity. The objective of this
Currow, David C., Ekstrom, Magnus, Ekström, Magnus, Johnson, Miriam J., Kaasa, S., Kaasa, Stein, Klepstad, Pal, Klepstad, Päl, Quinn, S., Quinn, Stephen, Somogyi, Andrew A.   +10 more
core   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

Advanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L. Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn   +9 more
wiley   +1 more source

Pharmacokinetic Profile of Fentanyl in the Koala (Phascolarctos cinereus) after Intravenous Administration, and Absorption via a Transdermal Patch

Animals, 2021
Fentanyl was administered as a single intravenous bolus injection at 5 µg/kg to five koalas and fentanyl plasma concentrations for a minimum of 2 h were quantified by an enzyme-linked immunosorbent assay (ELISA).
Fumie Tokonami, Benjamin Kimble, Merran Govendir   +2 more
doaj   +1 more source

Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry [PDF]

, 2017
The Centers for Disease Control and Prevention deemed the increase in overdose fatalities, due to the use of opioids, an “opioid epidemic” in the United States. Heroin, fentanyl, and other synthetic opioids are commonly abused and are contributing to the
Moore, Amanda Marie
core  

Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis

Advanced Science, EarlyView.
Microneedle suction cup patches, prepared using bionic Drosophila tarsal claws, can effectively treat bacterial infectious stomatitis by rapidly and efficiently leveraging multiple effects, including antibacterial and anti‐inflammatory properties, promotion of vasodilation, and active mechanical contraction of the wound.
Jiaqi Qin, Cewen Hu, Xiaohong Ran, Huajing Zeng, Jie Zhang, Bin Liu, Zengjie Fan   +6 more
wiley   +1 more source