Results 71 to 80 of about 188,238 (387)
Heroin Adulterated with the Novel Synthetic Cannabinoid, 5F-MDMB-PINACA: A Case Series [PDF]
, 2020 Introduction: Heroin can be adulterated with various substances that may or may not have pharmacological effects. Here we report a case series of 8 patients who presented to the emergency department after overdose with intravenous heroin preparation ...
Arnold, Ryan +5 more
core
Feasibility of adding magnesium to intrathecal fentanyl in pediatric cardiac surgery [PDF]
, 2011 BackgroundMagnesium is (NMDA) receptor antagonist used as an adjuvant for postoperative analgesia. There are several studies comparing the efficacy of the different routes of administration of magnesium.
Alghareeb, Nawal Abdelgalil +4 more
core +1 more source
Characteristics of Fentanyl Overdose — Massachusetts, 2014–2016
MMWR. Morbidity and mortality weekly report, 2017 Opioid overdose deaths in Massachusetts increased 150% from 2012 to 2015 (1). The proportion of opioid overdose deaths in the state involving fentanyl, a synthetic, short-acting opioid with 50-100 times the potency of morphine, increased from 32% during ...
Nicholas J. Somerville +12 more
semanticscholar +1 more source
Addiction Biology, 2020 The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self‐administration with the intermittent access (IntA) procedure produces a robust addiction‐like state that is orexin‐dependent.
Jennifer E. Fragale +2 more
semanticscholar +1 more source
Animals, 2021 Fentanyl was administered as a single intravenous bolus injection at 5 µg/kg to five koalas and fentanyl plasma concentrations for a minimum of 2 h were quantified by an enzyme-linked immunosorbent assay (ELISA).
Fumie Tokonami +2 more
doaj +1 more source
Journal of Pharmacology and Experimental Therapeutics, 2020 Synthetic opioids, including fentanyl and its analogs, have therapeutic efficacy in analgesia and anesthesia. However, their illicit use in the United States has increased and contributed to the number one cause of death for adults 18–50 years old ...
Randy Torralva +8 more
semanticscholar +1 more source
Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry [PDF]
, 2017 The Centers for Disease Control and Prevention deemed the increase in overdose fatalities, due to the use of opioids, an “opioid epidemic” in the United States. Heroin, fentanyl, and other synthetic opioids are commonly abused and are contributing to the
Moore, Amanda Marie
core
Treatment with subcutaneous and transdermal fentanyl: Results from a population pharmacokinetic study in cancer patients [PDF]
, 2016 Purpose: Transdermal fentanyl is effective for the treatment of moderate to severe cancer-related pain but is unsuitable for fast titration. In this setting, continuous subcutaneous fentanyl may be used.
Abrantes, J.A. (João) +7 more
core +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
BMC Global and Public HealthBackground In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk.
Katherine LeMasters +10 more
doaj +1 more source