Results 71 to 80 of about 195,889 (397)
Addiction Biology, 2020 The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self‐administration with the intermittent access (IntA) procedure produces a robust addiction‐like state that is orexin‐dependent.
Jennifer E. Fragale +2 more
semanticscholar +1 more source
Advanced Science, EarlyView.A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang +9 more
wiley +1 more source
Journal of Pharmacology and Experimental Therapeutics, 2019 In December 2018, the Centers for Disease Control declared fentanyl the deadliest drug in America. Opioid overdose is the single greatest cause of death in the United States adult population (ages 18–50), and fentanyl and its analogs [fentanyl/fentanyl ...
Randy Torralva, A. Janowsky
semanticscholar +1 more source
Trends in long-term prescribing of dependence forming medicines [PDF]
, 2019 Using patient-level primary care data to estimate the extent to which antidepressant medicines are prescribed to people continuously for long periods of time.
McManus, S. +3 more
core
Trump Tariffs 2.0: Assessing the Impacts on US Distilled Spirits Imports
Agribusiness, EarlyView.ABSTRACT The proposed 25% tariff on Mexico and Canada could have significant repercussions on US imports of distilled spirits. This study estimates US import demand across various spirit categories (e.g., tequila, whiskey) and assesses the potential impact of the proposed tariff.
Andrew Muhammad
wiley +1 more source
Animals, 2021 Fentanyl was administered as a single intravenous bolus injection at 5 µg/kg to five koalas and fentanyl plasma concentrations for a minimum of 2 h were quantified by an enzyme-linked immunosorbent assay (ELISA).
Fumie Tokonami +2 more
doaj +1 more source
Metabolic Pathways and Potencies of New Fentanyl Analogs
Frontiers in Pharmacology, 2019 Up to now, little is known about the metabolic pathways of new fentanyl analogs that have recently emerged on the drug markets worldwide with high potential for producing addiction and severe adverse effects including coma and death.
Maurice Wilde +6 more
semanticscholar +1 more source
Therapeutic and Prophylactic Vaccines to Counteract Fentanyl Use Disorders and Toxicity.
Journal of Medicinal Chemistry, 2020 The incidence of fatal overdoses has increased worldwide due to the widespread access to illicit fentanyl and its potent analogues. Vaccines offer a promising strategy to reduce the prevalence of opioid use disorders (OUDs) and to prevent toxicity from ...
Christine Robinson +12 more
semanticscholar +1 more source
Treatment with subcutaneous and transdermal fentanyl: Results from a population pharmacokinetic study in cancer patients [PDF]
, 2016 Purpose: Transdermal fentanyl is effective for the treatment of moderate to severe cancer-related pain but is unsuitable for fast titration. In this setting, continuous subcutaneous fentanyl may be used.
Abrantes, J.A. (João) +7 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Analgesic medicines are an important component of pain management, with different medicines carrying different risks and benefits. The aim of this study was to examine trends in analgesic prescribing in Ireland and England between 2014 and 2022. Methods Monthly data on medicines prescribed and dispensed in primary care were used. For Ireland, data
Molly Mattsson +8 more
wiley +1 more source