Results 91 to 100 of about 184,026 (339)

Abuse potential of fentanyl and fentanyl analogues

BioImpacts
Introduction: In this perspective review, we evaluated the clinical management of fatal fentanyl overdose in several routes of administration, concentrating on both legally prescribed and illegally produced formulations. Methods: A literature search was conducted on Web of Science, PubMed, and Google Scholar databases, using the following keywords ...
Anusha Thumma, Kwadwo Mfoafo, Niloofar Babanejad, Alborz Omidian, Yadollah Omidi, Hamid Omidian   +5 more
openaire   +3 more sources

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Naloxone reversal of the cardiorespiratory depressant effects of opioids and mixtures of opioids and stimulants in rats

Frontiers in Pharmacology
Co-use of opioids (e.g., fentanyl) and stimulants (e.g., methamphetamine; METH) contributed to >30% of the almost 106,000 fatal overdoses in the United States in 2023.
Jacqueline M. Vazquez, Robert W. Seaman, Drew Caldron, Gregory T. Collins, Gregory T. Collins   +4 more
doaj   +1 more source

The effect of nitrous oxide in comparison to oxygen combined with fentanyl on the hospitalization time and pain reduction in renal colic patients at emergency department

Journal of Research in Medical Sciences, 2018
Background: Renal colic is a painful medical emergency, needs urgent intervention to reduce pain. Nonsteroidal anti-inflammatory drugs, opioids, and entonox are pain-relieving agents. This study was aimed to compare fentanyl + entonox (nitrous oxide + O2)
Omid Ahmadi, Amir Shirvani Dehkordi, Farhad Heydari, Mohammad Nasr Esfahani, Behzad Mahaki   +4 more
doaj   +1 more source

Propofol-Based Procedural Sedation with or without Low-Dose Ketamine in Children [PDF]

, 2016
Objective Examine comparative dosing, efficacy, and safety of propofol alone or with an initial, subdissociative dose of ketamine approach for deep sedation. Background Propofol is a sedative-hypnotic agent used increasingly in children for deep sedation.
Ahmed, Sheikh Sohail, Hedlund, Lauren, Hicks, Shawn, Nitu, Mara, Rigby, Mark R., Slaven, James E.   +5 more
core   +1 more source

Identification and Characterization of the Designer Opioid N‐Pyrrolidino Fluetonitazene in Nasal Spray

Drug Testing and Analysis, EarlyView.
N‐Pyrrolidino fluetonitazene, a synthetic opioid, was identified and characterized in a nasal spray using GC‐MS, LC‐QTOF‐MS, NMR and FT‐IR. ABSTRACT Detection of drugs in non‐biological samples serves as a fundamental basis for identifying emerging trends in the field of new psychoactive substances and provides valuable information for optimizing ...
Fabian Picht, Valentin Cepus, Rona Hohlfeld, Julian Klingbeil, Marco Weber   +4 more
wiley   +1 more source

Combination of magnesium sulphate and ropivacaine epidural analgesia for hip arthroplasty in dogs [PDF]

, 2017
The aim of this study was to determine whether lumbosacral epidural administration of magnesium sulphate added to ropivacaine prolongs and improves perioperative analgesia, without adverse effects on motor block duration or hind limb neurological ...
Adami, C, Lardonea, E, Peironea, B
core   +2 more sources

Microelectrode array scaled for human hippocampal slices

Epilepsia Open, EarlyView.
Abstract Objective Temporal lobe epilepsy (TLE) is characterized by recurrent seizures originating usually from the hippocampus, and approximately one‐third of TLE patients remain refractory to pharmacological interventions. Surgical resection offers a potential cure for refractory TLE cases, with approximately 70% achieving seizure freedom. Still, the
Anssi Pelkonen, Vera Lezhneva, Tomi Ryynänen, Joose Kreutzer, Valeriia Sitnikova, Mireia Gómez‐Budia, Adriana Della Pietra, Antonios Dougalis, Jenni Kyyriäinen, Mastaneh Torkamani‐Azar, Henri Eronen, Tuomas Rauramaa, Arto Immonen, Ville Leinonen, Alejandra Sierra, Reetta Kälviäinen, Tarja Malm   +16 more
wiley   +1 more source

Evaluating fentanyl test strips as a harm reduction strategy in rural and urban counties: study protocol for a randomized controlled trial

Trials
Background Opioid-related fatalities are a leading cause of death in Ohio and nationally, with an increasing number of overdoses attributable to fentanyl. Rapid fentanyl test strips can identify fentanyl and some fentanyl analogs in urine samples and are
Ashley Short Mejia, Gary A. Smith, Soledad A. Fernandez, Bridget Freisthler, Christine Grella, Nichole L. Michaels   +5 more
doaj   +1 more source

Association between gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery

Molecular Pain, 2016
Background Fentanyl is often used instead of morphine for the treatment of pain because it has fewer side effects. The metabolism of morphine by glucuronidation is known to be influenced by polymorphisms of the UGT2B7 gene.
Wataru Muraoka DDS, Daisuke Nishizawa PhD, Kenichi Fukuda DDS, PhD, Shinya Kasai PhD, Junko Hasegawa BAgr, Koichi Wajima DDS, PhD, Taneaki Nakagawa DDS, PhD, Kazutaka Ikeda PhD   +7 more
doaj   +1 more source