Results 41 to 50 of about 1,285,314 (289)

Assessing teachers’ beliefs to facilitate the transition to a new chemistry curriculum: what do the teachers want? [PDF]

, 2008
In this article, we describe the results of a study of chemistry high school teachers’ beliefs (N = 7) of the chemistry curriculum and their roles, their beliefs on the teacher as developer of materials, and their beliefs about professional development ...
Coenders, Fer, Dijkstra, Sanne, Terlouw, Cees   +2 more
core   +4 more sources

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity

Frontiers in Cellular Neuroscience, 2019
The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs).
Etienne Côme, Etienne Côme, Etienne Côme, Martin Heubl, Martin Heubl, Martin Heubl, Eric J. Schwartz, Eric J. Schwartz, Eric J. Schwartz, Jean Christophe Poncer, Jean Christophe Poncer, Jean Christophe Poncer, Sabine Lévi, Sabine Lévi, Sabine Lévi   +14 more
doaj   +1 more source

Facial Motion Prior Networks for Facial Expression Recognition

, 2019
Deep learning based facial expression recognition (FER) has received a lot of attention in the past few years. Most of the existing deep learning based FER methods do not consider domain knowledge well, which thereby fail to extract representative ...
Cai, Jianfei, Chen, Shikai, Chen, Yuedong, Shi, Zhongchao, Wang, Jianfeng   +4 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Signaling from the cytoplasm to the nucleus in striatal medium-sized spiny neurons

Frontiers in Neuroanatomy, 2011
Striatal medium-sized spiny neurons (MSNs) receive massive glutamate inputs from the cerebral cortex and thalamus and are a major target of dopamine projections.
Miriam eMatamales, Miriam eMatamales, Miriam eMatamales, Jean-Antoine eGirault, Jean-Antoine eGirault, Jean-Antoine eGirault   +5 more
doaj   +1 more source

On quasi-Pr\"{u}fer and UM$t$ domains [PDF]

, 2011
In this note we show that an integral domain $D$ of finite $w$-dimension is a quasi-Pr\"{u}fer domain if and only if each overring of $D$ is a $w$-Jaffard domain.
Sahandi, Parviz
core  

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Doublecortin mutation leads to persistent defects in the Golgi apparatus and mitochondria in adult hippocampal pyramidal cells

Neurobiology of Disease, 2022
Human doublecortin (DCX) mutations are associated with severe brain malformations leading to aberrant neuron positioning (heterotopia), intellectual disability and epilepsy.
M.A. Stouffer, R. Khalaf-Nazzal, C. Cifuentes-Diaz, G. Albertini, E. Bandet, G. Grannec, V. Lavilla, J.-F. Deleuze, R. Olaso, M. Nosten-Bertrand, F. Francis   +10 more
doaj   +1 more source

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source