Results 131 to 140 of about 29,761,483 (233)

A Personal Perspective on Metalloprotein Structure and the Future of Macromolecular X‐Ray Crystallography

Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1243-1250, September 2026.
While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley   +1 more source

Organizational and Functional Principles of the Obligate Respiratory Chain Supercomplex

Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1307-1323, September 2026.
In this review we deliver a comprehensive structural analysis of the actinobacterial respiratory chain supercomplex and discuss the principles underlying the assembly of its supramolecular architecture. ABSTRACT Proton translocating respiratory chain complexes assemble into supramolecular structures in their native cellular environment, yet the ...
Wei‐Chun Kao, Nick Hiatt, Carola Hunte
wiley   +1 more source

Effects of electroacupuncture intervention at different time points on cuproptosis-related proteins and copper homeostasis in rats with cerebral ischemia-reperfusion injury

针刺研究
ObjectiveTo observe the effects of electroacupuncture （EA） intervention at different time points on cuproptosis-related proteins and Cu2+ levels in the ischemic penumbra of rats with cerebral ischemia-reperfusion injury （CIRI） after acute ischemic stroke
Wang Yufei, Meng Jia, Huang Liujiao
doaj   +2 more sources

Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy?

Cell Communication and Signaling
Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and dysbalanced metabolism were associated with the disruption of intracellular respiration and the
Ruiwen Zhao, Olga Sukocheva, Edmund Tse, Margarita Neganova, Yulia Aleksandrova, Yufei Zheng, Hao Gu, Deyao Zhao, SabbaRao V. Madhunapantula, Xiaorong Zhu, Junqi Liu, Ruitai Fan   +11 more
doaj   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

TRMT61A‐Mediated m1A Modification Suppresses FDX1 Translation to Drive Cuproptosis Evasion and Radioresistance in Hepatocellular Carcinoma

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This study identifies tRNA methyltransferase 61 A (TRMT61A)‐mediated N1‐methyladenosine (m1A) modification as a driver of radioresistance in hepatocellular carcinoma (HCC) by suppressing cuproptosis. TRMT61A methylates FDX1 mRNA, enabling YTHDF3 recognition and eRF1 recruitment to inhibit FDX1 translation.
Yunyun Xiao, Yue Li, Zelei Li, Rui Wang, Dongni Shi, Yanling Wen, Yibing Pan, Chen Lin, Junguo Bu, Libing Song, Hui Dai   +10 more
wiley   +1 more source

Modulating ovarian cancer progression through FDX1-driven autophagy

npj Precision Oncology
Ferredoxin 1 (FDX1) emerges as a crucial regulator of autophagy and copper metabolism in ovarian cancer (OC), as revealed by this investigation. Predominantly localized to the cytoplasm and mitochondria, FDX1 coordinates autophagic activity by modulating
Chang Liu, Siyu Wang, Jiabao Zhao, Hui Qiu, Hongmei Du   +4 more
doaj   +1 more source

LIPE‐AS1 Facilitates Prostate Cancer Progression via Suppressing Cuproptosis Through the miR‐330‐3p/MGAT5 Axis

MedComm – Oncology, Volume 5, Issue 3, September 2026.
LIPE‐AS1 is markedly upregulated and serves as a competitive endogenous RNA that sponges miR‐330‐3p. This sequestration relieves miR‐330‐3p‐mediated repression of MGAT5, leading to elevated MGAT5, which subsequently suppresses cuproptosis‐related proteins FDX1, DLAT, and DLST, thus diminishing cuproptosis sensitivity.
Qiang Shen, Qu Leng, Kaihui Wu, Guorui Li, Yiyou Mao, Jun Wu, Ziyi Song, Zhihai Deng, Hangyang Peng, Jun Zou, Jiamin Wang, Ping Liu, Zihao Zou, Zhaojun Pan, Jianfeng Zhong, Yubin Li, Nan Deng, Xiangming Mao, Daojun Lv   +18 more
wiley   +1 more source

Involvement of the chloroplast gene ferredoxin 1 in multiple responses of Nicotiana benthamiana to Potato virus X infection. [PDF]

J Exp Bot, 2020
Yang X, Lu Y, Wang F, Chen Y, Tian Y, Jiang L, Peng J, Zheng H, Lin L, Yan C, Taliansky M, MacFarlane S, Wu Y, Chen J, Yan F.   +14 more
europepmc   +1 more source

Quaternary structures of Streptococcus pneumoniae nucleoside diphosphate kinase: From hexamers to supramolecular assemblies

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The nucleoside diphosphate kinase (NDK) is a key enzyme that controls the balance of nucleotide pools in all living organisms. Beyond this fundamental role, NDKs exert pleiotropic effects in many cellular processes, including cell development, signal transduction, differentiation, tumor metastasis, and gene expression. The quaternary structure
Julie Kerboeuf, Paul Nouri, Frédéric Galisson, Laetitia Daury, Marie‐France Giraud, Olivier Lambert, Cédric Orelle, Lionel Ballut, Elise Kaplan, Jean‐Michel Jault, Cécile Gonzalez   +10 more
wiley   +1 more source