Ferrochelatase and Magnesiumchelatase: Metal chelation studied with mutants
, 2003 Magnesium chelatase and ferrochelatase are two very important enzymes, which are involved in chlorophyll and heme biosynthesis, respectively. They both use protoporphyrin IX as substrate but magnesium chelatase inserts a magnesium ion whereas ...
Olsson, Ulf
core
The interrelationship between ferrochelatase and protoporphyrinogen oxidase with particular reference to porphyria variegata and erythropoietic protoporphyria [PDF]
, 1986 This thesis was undertaken to determine if there is any interrelationship between the two terminal enzymes of the haem biosynthetic pathway, protoporphyrinogen oxidase (PPO) and ferrochelatase, with particular reference to porphyria variegata (PV) and ...
Siepker, Lydia, Johanna
core
Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells
, 2000 Ferrochelatase, the last enzyme in the heme pathway, chelates protoporphyrin IX and iron to form heme and is mutated in protoporphyria. The ferrochelatase gene is expressed in all tissues at low levels to provide heme for essential heme-containing ...
Magness, Scott T. +2 more
core +1 more source
Mitochondrial Heme Synthesis Enzymes as Therapeutic Targets in Vascular Diseases
Frontiers in Pharmacology, 2020 Trupti Shetty +4 more
doaj +1 more source
Erythropoietic protoporphyria: A functional analysis of the leader sequence of human ferrochelatase
, 2006 Erythropoietic protoporphyria (EPP) results from an inherited partial deficiency of ferrochelatase, the terminal enzyme of haem biosynthesis. Excess protoporphyrin IX accumulates in erythrocytes, plasma, liver, and skin, which mediates a distinctive form
Roberts, Andrew +2 more
core +1 more source
Human Frataxin: Iron and Ferrochelatase Binding Surface
, 2007 The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein’s ability to serve as the iron chaperone during heme ...
Bradley, Patrick B. +6 more
core
BiomoleculesChemical proteomics using biotin probes of natural products have significantly advanced our understanding of molecular targets and therapeutic potential.
Xiang Fei +6 more
doaj +1 more source
Site directed mutagenesis and kinetic study of ferrochelatase from chironomidae larvae. [PDF]
, 2004 Wong Kwong Fai.Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.Includes bibliographical references (leaves 97-104).Abstracts in English and Chinese.Acknowledgements --- p.iAbstract --- p.iiList of Figures --- p.xList of Tables --- p.xiList of
core
, 2019 International audienceNon-syndromic microcytic congenital sideroblastic anemia (cSA) is predominantly caused by defective genes encoding for either ALAS2, the first enzyme of heme biosynthesis pathway or SLC25A38, the mitochondrial importer of glycine ...
Moulouel, Boualem +10 more
core +1 more source
Identification and Characterization of Solvent-Filled Channels in Human Ferrochelatase
, 2016 Ferrochelatase catalyzes the formation of protoheme from two potentially cytotoxic products, iron and protoporphyrin IX. While much is known from structural and kinetic studies on human ferrochelatase of the dynamic nature of the enzyme during catalysis ...
Amy E. Medlock (784951) +7 more
core +1 more source