Results 91 to 100 of about 5,252 (212)

Chronic Myeloid Leukaemia Developing During Long‐Term Alectinib Therapy Successfully Managed With Concomitant Nilotinib: A Case Report

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a case of chronic myeloid leukaemia (CML) diagnosed during long‐term alectinib therapy in a patient with ALK‐positive non‐small cell lung cancer, in whom CML was confirmed by the presence of the BCR‐ABL1 fusion gene and concomitant nilotinib with continued alectinib achieved a rapid hematologic response without significant adverse events ...
Yuki Ikematsu, Miiru Izumi, Kentaro Wakamatsu, Masayuki Kawasaki   +3 more
wiley   +1 more source

The interrelationship between ferrochelatase and protoporphyrinogen oxidase with particular reference to porphyria variegata and erythropoietic protoporphyria [PDF]

, 1986
This thesis was undertaken to determine if there is any interrelationship between the two terminal enzymes of the haem biosynthetic pathway, protoporphyrinogen oxidase (PPO) and ferrochelatase, with particular reference to porphyria variegata (PV) and ...
Siepker, Lydia, Johanna
core  

A model for tetrapyrrole synthesis as the primary mechanism for plastid-to-nucleus signaling during chloroplast biogenesis

Frontiers in Plant Science, 2013
Chloroplast biogenesis involves the co-ordinated expression of the chloroplast and nuclear genomes, requiring information to be sent from the developing chloroplasts to the nucleus.
Matthew J. Terry, Matthew J. Terry, Alison G. Smith   +2 more
doaj   +1 more source

Heme Synthesis Inhibition Blocks Angiogenesis via Mitochondrial Dysfunction

iScience, 2020
Summary: The relationship between heme metabolism and angiogenesis is poorly understood. The final synthesis of heme occurs in mitochondria, where ferrochelatase (FECH) inserts Fe2+ into protoporphyrin IX to produce proto-heme IX.
Trupti Shetty, Kamakshi Sishtla, Bomina Park, Matthew J. Repass, Timothy W. Corson   +4 more
doaj   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Erythropoietic Protoporphyria and Surgery: A Case of Successful Mastectomy With Perioperative Light Shielding Strategies Based on Light‐Induced Hemolytic Threshold Assessment

The Journal of Dermatology, Volume 53, Issue 6, Page 930-933, June 2026.
ABSTRACT A 50‐year‐old female patient was referred to our department for consultation regarding perioperative management of breast cancer surgery. She had a history of photosensitivity since childhood and was diagnosed with erythropoietic protoporphyria (EPP) during her first pregnancy.
Fumika Tateishi, Naoya Murayama, Ruri Nakamuta, Masahisa Watanabe, Aya Tanaka, Hiroyuki Murota   +5 more
wiley   +1 more source

Erythropoietic protoporphyria: A functional analysis of the leader sequence of human ferrochelatase

, 2006
Erythropoietic protoporphyria (EPP) results from an inherited partial deficiency of ferrochelatase, the terminal enzyme of haem biosynthesis. Excess protoporphyrin IX accumulates in erythrocytes, plasma, liver, and skin, which mediates a distinctive form
Roberts, Andrew, Cobbold, Christian, Badminton, Michael   +2 more
core   +2 more sources

Transcriptional regulation of tetrapyrrole biosynthetic genes explains abscisic acid-induced heme accumulation in the unicellular red alga Cyanidioschyzon merolae

Frontiers in Plant Science, 2016
Abscisic acid (ABA), a pivotal phytohormone that is synthesized in response to abiotic stresses and other environmental changes, induces various physiological responses. Heme, in its unbound form, has a positive signaling role in cell-cycle initiation in
Yuki Kobayashi, Kan Tanaka, Kan Tanaka
doaj   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, Volume 208, Issue 6, Page 1980-1992, June 2026.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Chemical Characterization of Toxic Elements in Plastic Utensils: Key Insights and Health Impacts

CLEAN – Soil, Air, Water, Volume 54, Issue 5, May 2026.
Toxic elements in plastic utensils are assessed using portable X‐ray fluorescence and specific migration tests with water and 3% acetic acid as food simulants. Cadmium, lead, arsenic, and mercury are detected in the utensils, and migration results show exceedances of specific migration limits, particularly for lead, mercury, and cadmium. These findings
Elizeu Chiodi Pereira, Lucas Takeshi Shimizu Hossokawa, Isabelle Nogueira Leroux, Aline de Carvalho Elias, Maciel Santos Luz, Kelly Polido Kaneshiro Olympio   +5 more
wiley   +1 more source