Photodynamic therapy management of canine mammary gland tumour with wireless upconversion implant
VIEW, Volume 6, Issue 5, October 2025.For the first time ever, a wireless Near‐Infrared Photodynamic Therapy (PDT) system, powered by a highly efficient upconversion implant, has successfully been used to manage geriatric mammary gland tumors in geriatric dogs. This innovative approach involves implanting a high efficiency flexible upconversion silicone based implant just under the skin ...
Ivy Joy Toh +14 more
wiley +1 more source
Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation.
, 1998 Protoporphyria is a genetic disorder in which a deficiency of mitochondrial ferrochelatase activity causes accumulation of protoporphyrin that produces severe liver damage in some patients.
Bruzzone, C +11 more
core +1 more source
Mitochondrial localization of functional ferrochelatase from Plasmodium falciparum
, 2009 In the malarial parasite, enzymes of heme-biosynthetic pathway are distributed in different cellular compartments. The site of localization of ferrochelatase in the malarial parasite is crucial, since it will decide the ultimate site of heme synthesis.
Rangarajan, Pundi N +4 more
core +1 more source
Ferrochelatase: the convergence of the porphyrin biosynthesis and iron transport pathways
, 2011 Ferrochelatase (also known as PPIX ferrochelatase; Enzyme Commission number 4.9.9.1.1) catalyzes the insertion of ferrous iron into PPIX to form heme. This reaction unites the biochemically synchronized pathways of porphyrin synthesis and iron transport ...
Ferreira, Gloria C. +3 more
core +2 more sources
Crystallographic studies on porphyrin metallation by ferrochelatase.
, 2002 Ferrochelatase catalyses the terminal step in heme biosynthesis by inserting a ferrous ion into protoporphyrin IX. The reaction mechanism has in this thesis been studied by mainly crystallographic methods.
Lecerof, David
core
Purification and characterisation of a water-soluble ferrochelatase from Bacillus subtilis
, 1994 Bacillus subtilis ferrochelatase is encoded by the hemH gene of the hemEHY gene cluster and catalyses the incorporation of Fe2+ into protoporphyrin IX. B. subtilis ferrochelatase produced in Escherichia coli was purified.
Hederstedt, Lars, Hansson, Mats
core +1 more source
Cell modeling of heme deficiency using ferrochelatase mutations
, 2014 Provided herein, is a means for development of ferrochelatase variants with improved tolerance towards N-methyl protoporphyrin. Also disclosed are cell assay systems utilizing the variants, as the variants would confer resistance to N-methyl ...
Ferreira, Gloria C., Shi, Zhen
core
Bacterial Porphyrin Extraction and Quantification by LC/MS/MS Analysis
Bio-Protocol, 2015 Heme is an iron-containing porphyrin which acts as a prosthetic group in several enzymes involved in disparate functions, such as respiration and H2O2-scavenging.
Stefano Mancini, James Imlay
doaj +1 more source
Modulation of inhibition of ferrochelatase by N-methyl protoporphyrin
, 2013 Provided herein, is a means for development of ferrochelatase variants with improved tolerance towards N-methyl protoporphyrin. Also disclosed are cell assay systems utilizing the variants, as the variants would confer resistance to N-methyl ...
Ferreira, Gloria C., Shi, Zhen
core
Factors influencing the stability of heme and ferrochelatase: role of oxygen
, 1991 Ferrochelatase (EC 4.99.1.1) catalyzed heme synthesis is best accomplished in an anaerobic environment. Factors responsible for this phenomenon are not fully understood.
Punekar, N. S., Gokhale, R. S.
core +1 more source