Results 71 to 80 of about 4,768 (212)

Molecular Characterization of a Ferrochelatase Gene Defect Causing Anomalous RNA Splicing in Erythropoietic Protoporphyria

, 1994
Erythropoietic protoporphyria is an inherited disorder caused by deficient activity of the enzyme ferrochelatase. We have examined the ferrochelatase gene in an 11-year-old female with protoporphyria and have found that she is heterozygous for a mutation
Sarkany, Robert PE., Cox, Timothy M, Whitcombe, David M   +2 more
core   +1 more source

A cadmium stress-responsive gene AtFC1 confers plant tolerance to cadmium toxicity

BMC Plant Biology, 2017
Background Non-essential trance metal such as cadmium (Cd) is toxic to plants. Although some plants have developed elaborate strategies to deal with absorbed Cd through multiple pathways, the regulatory mechanisms behind the Cd tolerance are not fully ...
Jun Song, Sheng Jun Feng, Jian Chen, Wen Ting Zhao, Zhi Min Yang   +4 more
doaj   +1 more source

Infrared Photobiomodulation Modulates PpIX Production After Topical Methyl Aminolevulinate in Normal Human Skin: An Exploratory Study

Journal of Biophotonics, Volume 19, Issue 3, March 2026.
We demonstrate that NIR photobiomodulation can influence PpIX accumulation in normal human skin. Although subject to interindividual variability, the observed trends support PBM as a promising, noninvasive adjuvant to refine PDT protocols and manage photosensitizer production through mitochondrial stimulation.
Letícia Palombo Martinelli, Natasha Ferreira Mezzacappo, Ana Paula Silva, Priscila Menezes, Vanderlei Salvador Bagnato   +4 more
wiley   +1 more source

Localization of ferrochelatase in Plasmodium falciparum [PDF]

Biochemical Journal, 2004
Our previous studies have demonstrated de novo haem biosynthesis in the malarial parasite (Plasmodium falciparum and P. berghei). It has also been shown that the first enzyme of the pathway is the parasite genome-coded ALA (δ-aminolaevulinate) synthase localized in the parasite mitochondrion, whereas the second enzyme, ALAD (ALA dehydratase), is ...
Varadharajan, Sundaramurthy, Sagar, Chandrashekar BK, Rangarajan, Pundi N, Padmanaban, Govindarajan   +3 more
openaire   +2 more sources

Differential gene content and gene expression for bacterial evolution and speciation of Shewanella in terms of biosynthesis of heme and heme-requiring proteins

BMC Microbiology, 2019
Background Most species of Shewanella harbor two ferrochelatase paralogues for the biosynthesis of c-type cytochromes, which are crucial for their respiratory versatility.
Jingcheng Dai, Yaqi Liu, Shuangyuan Liu, Shuyang Li, Na Gao, Jing Wang, Jizhong Zhou, Dongru Qiu   +7 more
doaj   +1 more source

Engineering next‐generation crops through CRISPR‐mediated horizontal gene transfer

New Phytologist, Volume 249, Issue 6, Page 2683-2689, March 2026.
Summary Crops increasingly face overlapping stresses such as heat, drought, salinity, and pathogens that conventional breeding or genome editing rarely overcome in combination. To address this, we propose CRISPR‐enabled horizontal gene transfer (CRISPR‐HGT) as a programmable framework that recreates the evolutionary process by which plants historically
Madhab Kumar Sen, Amit Roy, Rajeev K. Varshney, Amrita Chakraborty   +3 more
wiley   +1 more source

The coproporphyrin ferrochelatase of Staphylococcus aureus : mechanistic insights into a regulatory iron binding site. [PDF]

, 2017
The majority of characterised ferrochelatase enzymes catalyse the final step of classical haem synthesis, inserting ferrous iron into protoporphyrin IX.
Hobbs, C., James D. Reid, Hobbs, Charlie, Charlie Hobbs, Reid, J.D., Mark Shepherd, Shepherd, M., Shepherd, Mark   +7 more
core   +1 more source

Characterization of a novel pathogenic variant in the FECH gene associated with erythropoietic protoporphyria

Molecular Genetics and Metabolism Reports, 2019
Erythropoietic protoporphyria (EPP) is an autosomal recessive deficiency in heme biosynthesis due to pathogenic variants in the ferrochelatase gene (FECH). Patients present with lifelong photosensitivity and potential liver disease.
Michele C. Kieke, Jacob Klemm, Arthur Rech Tondin, Victor Alencar, Nathan Johnson, Ashley M. Driver, Thomas Lentz, Gregory J. Fischer, Diane A. Caporale, Luke J. Drury   +9 more
doaj   +1 more source

Allocation of Heme is Differentially Regulated by Ferrochelatase Isoforms in Arabidopsis Cells

Frontiers in Plant Science, 2016
Heme is involved in various biological processes as a cofactor of hemoproteins located in various organelles. In plant cells, heme is synthesized by two isoforms of plastid-localized ferrochelatase, FC1 and FC2.
Nino Asuela Espinas, Nino Asuela Espinas, Koichi Kobayashi, Yasushi Sato, Nobuyoshi Mochizuki, Kaori Takahashi, Ryouichi Tanaka, Tatsuru Masuda   +7 more
doaj   +1 more source

Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy

Nature Communications, 2022
5-Aminolevulinic acid-based photodynamic therapy heavily depends on the biological transformation efficiency of 5-aminolevulinic acid to protoporphyrin IX, while the lack of an effective delivery system and imaging navigation are major hurdles in ...
Gang He, Yashi Li, Muhammad Rizwan Younis, Lian-Hua Fu, Ting He, Shan Lei, Jing Lin, Peng Huang   +7 more
doaj   +1 more source