Results 81 to 90 of about 5,252 (212)

A cadmium stress-responsive gene AtFC1 confers plant tolerance to cadmium toxicity

BMC Plant Biology, 2017
Background Non-essential trance metal such as cadmium (Cd) is toxic to plants. Although some plants have developed elaborate strategies to deal with absorbed Cd through multiple pathways, the regulatory mechanisms behind the Cd tolerance are not fully ...
Jun Song, Sheng Jun Feng, Jian Chen, Wen Ting Zhao, Zhi Min Yang   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, Volume 20, Issue 9, Page 2296-2322, September 2026.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Porphyrin Interactions with Wild Type and Mutant Mouse Ferrochelatase [PDF]

, 1999
Ferrochelatase (EC 4.99.1.1), the terminal enzyme of the heme biosynthetic pathway, catalyzes Fe2+ chelation into protoporphyrin IX. Resonance Raman and W-visible absorbance spectroscopes of wild type and engineered variants of murine ferrochelatase were
Ferreira, Gloria C., Shelnutt, John A., Franco, Ricardo, Lu, Yi, Ma, Jian-Guo   +4 more
core  

Differential gene content and gene expression for bacterial evolution and speciation of Shewanella in terms of biosynthesis of heme and heme-requiring proteins

BMC Microbiology, 2019
Background Most species of Shewanella harbor two ferrochelatase paralogues for the biosynthesis of c-type cytochromes, which are crucial for their respiratory versatility.
Jingcheng Dai, Yaqi Liu, Shuangyuan Liu, Shuyang Li, Na Gao, Jing Wang, Jizhong Zhou, Dongru Qiu   +7 more
doaj   +1 more source

Localization of ferrochelatase in Plasmodium falciparum [PDF]

Biochemical Journal, 2004
Our previous studies have demonstrated de novo haem biosynthesis in the malarial parasite (Plasmodium falciparum and P. berghei). It has also been shown that the first enzyme of the pathway is the parasite genome-coded ALA (δ-aminolaevulinate) synthase localized in the parasite mitochondrion, whereas the second enzyme, ALAD (ALA dehydratase), is ...
Varadharajan, Sundaramurthy, Sagar, Chandrashekar BK, Rangarajan, Pundi N, Padmanaban, Govindarajan   +3 more
openaire   +2 more sources

Characterization of a novel pathogenic variant in the FECH gene associated with erythropoietic protoporphyria

Molecular Genetics and Metabolism Reports, 2019
Erythropoietic protoporphyria (EPP) is an autosomal recessive deficiency in heme biosynthesis due to pathogenic variants in the ferrochelatase gene (FECH). Patients present with lifelong photosensitivity and potential liver disease.
Michele C. Kieke, Jacob Klemm, Arthur Rech Tondin, Victor Alencar, Nathan Johnson, Ashley M. Driver, Thomas Lentz, Gregory J. Fischer, Diane A. Caporale, Luke J. Drury   +9 more
doaj   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, Volume 5, Issue 3, Page 241-259, September 2026.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Metal Binding to Saccharomyces cerevisiae Ferrochelatase

, 2002
Ferrochelatase is the terminal enzyme in the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into protoporphyrin IX to produce protoheme IX.
Al-Karadaghi, Salam, Lecerof, David,, Lecerof, David, Labbe-Bois, Rosine, Karlberg, Tobias,, Hansson, Mats,, Lund University., Silvergren, Germund, Hansson, Mats, Gora, Monika, Karlberg, Tobias, Al-Karadaghi, Salam,   +11 more
core   +1 more source

PufQ regulates porphyrin flux at the haem/bacteriochlorophyll branchpoint of tetrapyrrole biosynthesis via interactions with ferrochelatase [PDF]

, 2017
Facultative phototrophs such as Rhodobacter sphaeroides can switch between heterotrophic and photosynthetic growth. This transition is governed by oxygen tension and involves the large-scale production of bacteriochlorophyll, which shares a biosynthetic ...
Jackson, P.J., Chidgey, J.W., Mark J. Dickman, Dickman, M.J., Jack W. Chidgey, Philip J. Jackson, C. Neil Hunter, Hunter, C.N.   +7 more
core   +1 more source

Allocation of Heme is Differentially Regulated by Ferrochelatase Isoforms in Arabidopsis Cells

Frontiers in Plant Science, 2016
Heme is involved in various biological processes as a cofactor of hemoproteins located in various organelles. In plant cells, heme is synthesized by two isoforms of plastid-localized ferrochelatase, FC1 and FC2.
Nino Asuela Espinas, Nino Asuela Espinas, Koichi Kobayashi, Yasushi Sato, Nobuyoshi Mochizuki, Kaori Takahashi, Ryouichi Tanaka, Tatsuru Masuda   +7 more
doaj   +1 more source