Results 81 to 90 of about 4,768 (212)
Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion
, 1999 Protoporphyria is a disease characterized by a deficiency in ferrochelatase, the terminal enzyme in the heme biosynthetic pathway, which catalyzes the chelation of iron and protoporphyrin to form heme.
Magness, Scott T., Brenner, David A.
core +1 more source
Frontiers in Plant Science, 2013 Chloroplast biogenesis involves the co-ordinated expression of the chloroplast and nuclear genomes, requiring information to be sent from the developing chloroplasts to the nucleus.
Matthew J. Terry +2 more
doaj +1 more source
Heme Synthesis Inhibition Blocks Angiogenesis via Mitochondrial Dysfunction
iScience, 2020 Summary: The relationship between heme metabolism and angiogenesis is poorly understood. The final synthesis of heme occurs in mitochondria, where ferrochelatase (FECH) inserts Fe2+ into protoporphyrin IX to produce proto-heme IX.
Trupti Shetty +4 more
doaj +1 more source
Investigation of an atypical protoporphyric family in South Africa
, 2010 Includes bibliographical references (leaves 171-184).Affected members of the family investigated in this dissertation presented with photosensitivity and raised red cell protoporphyrin concentrations, indicative of protoporphyria.
Haumann, Carel Eduard
core
Arabidopsis thaliana ferrochelatase-I and -II are not imported into Arabidopsis mitochondria
, 2001 Using in vitro import assays into purified mitochondria and chloroplasts we found that Arabidopsis ferrochelatase-I and ferrochelatase-II were not imported into mitochondria purified from Arabidopsis (or several other plants) but were imported into pea ...
Orinda Chew +9 more
core +1 more source
Frontiers in Plant Science, 2016 Abscisic acid (ABA), a pivotal phytohormone that is synthesized in response to abiotic stresses and other environmental changes, induces various physiological responses. Heme, in its unbound form, has a positive signaling role in cell-cycle initiation in
Yuki Kobayashi, Kan Tanaka, Kan Tanaka
doaj +1 more source
Persistent Beetroot Colored Urine in a Three‐Year‐Old Child: A Case Report
Clinical Case Reports, Volume 13, Issue 10, October 2025.Clinically manifest porphyria cutanea tarda (PCT) is rare in children. Of ~1400 cases diagnosed at Porphyria Center Sweden, only five were children, all with pathogenic UROD variants and HFE homozygous. Diagnosis is often delayed; in our case, beetroot‐red urine prompted suspicion despite the absence of cutaneous symptoms.
Pauline Harper +2 more
wiley +1 more source
, 1977 Regulatory factors affecting ferrochelatase activity were studied and an attempt was made to determine the role of ferrochelatase in the regulation of heme biosynthesis.
Simpson, Denyse Marie
core
Porphyrin-substrate Binding to Murine Ferrochelatase: Effect on the Thermal Stability of the Enzyme
, 2005 Ferrochelatase (EC 4.99.1.1), the terminal enzyme of the haem biosynthetic pathway, catalyses the chelation of Fe(II) into the protoporphyrin IX ring.
Ferreira, Gloria C. +5 more
core +1 more source
Pulmonary Circulation, Volume 15, Issue 4, October 2025.ABSTRACT Pulmonary arterial hypertension (PAH) is a life‐threatening condition characterized by elevated pulmonary vascular resistance. Despite recent advances, early diagnosis remains challenging due to nonspecific symptoms. By utilizing RNA sequencing (RNA‐seq) data from the GEO database, we conducted bioinformatics analyses to identify potential ...
Huan Liu +4 more
wiley +1 more source