Results 81 to 90 of about 4,023 (167)

Mitochondrial Heme Synthesis Enzymes as Therapeutic Targets in Vascular Diseases

Frontiers in Pharmacology, 2020
Trupti Shetty, Trupti Shetty, Timothy W. Corson, Timothy W. Corson, Timothy W. Corson   +4 more
doaj   +1 more source

Exploring the Antiangiogenic and Anti-Inflammatory Potential of Homoisoflavonoids: Target Identification Using Biotin Probes

Biomolecules
Chemical proteomics using biotin probes of natural products have significantly advanced our understanding of molecular targets and therapeutic potential.
Xiang Fei, Sangil Kwon, Jinyoung Jang, Minyoung Seo, Seongwon Yu, Timothy W. Corson, Seung-Yong Seo   +6 more
doaj   +1 more source

FECH, a novel metabolic target influencing CAR T-cell phenotype and function

Biomarker Research
Recent phase I/II clinical trials have demonstrated that chimeric antigen receptor (CAR) T cells targeting the disialogangliosade GD2 represent a promising therapeutic option for pediatric patients with relapsed or refractory high-risk neuroblastoma (NB).
Marsha Pellegrino, Simone Vespa, Illari Salvatori, Giang Dang Mac, Cristiana Valle, Valerio Secli, Sara Cairoli, Bianca Maria Goffredo, Matteo Caforio, Valentina Folgiero, Lokossou William Sanvi, Elisabetta Vulpis, Elena Ciampini, Marco Scarsella, Ezio Giorda, Ferdinando Chiaradonna, Manuela Giansanti, Francesca Nazio, Alberto Ferri, Francesco Cecconi, Silvia Campello, Enrico Velardi, Ignazio Caruana, Emmanuel de Billy   +23 more
doaj   +1 more source

Case Report: Cholestatic liver disease in the course of erythropoietic protoporphyria associated with renal hypodysplasia and atrial septal defect

Frontiers in Pediatrics
Erythropoietic protoporphyria (EPP) is an autosomal recessive disorder of the heme biosynthesis pathway caused by pathogenic variants in FECH gene resulting in a decreased activity of ferrochelatase.
Patryk Lipiński, Agnieszka Lipniacka, Maja Klaudel-Dreszler, Lidia Ziółkowska, Grażyna Kostrzewa, Edyta Odnoczko, Robert Wasilewski, Rafał Płoski, Anna Tylki-Szymańska   +8 more
doaj   +1 more source

Erythropoietic protoporphyria and early onset of cholestasis

The Turkish Journal of Pediatrics, 2012
Erythropoietic protoporphyria (EPP) is an inherited defect of mitochondrial ferrochelatase. This defect results in accumulation of protoporphyrin in erythrocytes, plasma, liver, and skin, which causes severe photosensitivity.
Mani Jeh Khalili, Fatemeh Farahmand, Armin Hirbod-Mobarakeh, Azizollah Yousefi, Soheila Sotoudeh, Maryam Monajemzadeh, Anahita Razaghian, Nima Rezaei   +7 more
doaj  

The 6-year follow-up of a Japanese patient with silent erythropoietic protoporphyria

JAAD Case Reports, 2017
Megumi Mizawa, MD, PhD, Teruhiko Makino, MD, PhD, Fumina Furukawa, MD, Ryotaro Torai, MD, Hajime Nakano, MD, PhD, Daisuke Sawamura, MD, PhD, Tadamichi Shimizu, MD, PhD   +6 more
doaj   +1 more source

Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract [PDF]

Biochemical Journal, 1963
R J, PORRA, O T, JONES
openaire   +2 more sources

Ferrochelatase [PDF]

, 2018
openaire   +2 more sources

Proteomics dataset of liver tissue from spinal muscular atrophy, heterozygous, and wild-type mice, enabling pathway identification. [PDF]

Data Brief
Vrettou S, Müller S, Wirth B.
europepmc   +1 more source

SHP-1 agonist SC-43 limits methicillin-resistant Staphylococcus aureus infection through inhibition of heme biosynthesis. [PDF]

EMBO Mol Med
Huang Y, Ye Y, Zhu X, Liang D, Cui R, Yuan X, Li X, Zou Q, Li H, Huang W.   +9 more
europepmc   +1 more source