Results 61 to 70 of about 5,252 (212)
Metal Ion Substrate Inhibition of Ferrochelatase [PDF]
Journal of Biological Chemistry, 2008 Ferrochelatase catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme. Robust kinetic analyses of the reaction mechanism are complicated by the instability of ferrous iron in aqueous solution, particularly at alkaline pH values. At pH 7.00 the half-life for spontaneous oxidation of ferrous ion is approximately 2 min in the absence ...
Gregory A, Hunter +2 more
openaire +2 more sources
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background Erythropoietic protoporphyria (EPP) is a rare genetic disorder characterized by severe phototoxic reactions that occur within minutes of light exposure. In clinical studies, afamelanotide has been shown to prolong pain‐free sun exposure, improve quality of life, and reduce the frequency and severity of phototoxic reactions ...
Magdalena Seidl‐Philipp +9 more
wiley +1 more source
MetabolitesBackground/Objectives: Isoniazid (INH) and pyrazinamide (PZA) are first-line drugs used to treat tuberculosis (TB), but their use is generally contraindicated in patients with porphyria, a group of metabolic disorders caused by defects in the heme ...
Fu-Ying Qin +6 more
doaj +1 more source
Identification of a bacteria-like ferrochelatase in Strongyloides venezuelensis, an animal parasitic nematode. [PDF]
PLoS ONE, 2013 Heme is an essential molecule for vast majority of organisms serving as a prosthetic group for various hemoproteins. Although most organisms synthesize heme from 5-aminolevulinic acid through a conserved heme biosynthetic pathway composed of seven ...
Eiji Nagayasu +6 more
doaj +1 more source
Porphyromonas gingivalis and Ferroptosis: Evidence, Limitations, and Significance
Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.ABSTRACT Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontal dysbiosis and has been linked to multiple systemic diseases. Ferroptosis is a form of regulated cell death driven by iron‐dependent lipid peroxidation, and accumulating evidence implicates it in P. gingivalis‐associated tissue injury.
Xiaoting Fang +5 more
wiley +1 more source
The effect of chloramphenicol treatment on ferrochelatase activity in dogs
, 1970 Chloramphenicol fed to dogs at a dose of 100 mg/kg/day resulted in a decrease in bone marrow ferrochelatase activity to 5–35% of control levels.
Manyan, David R, Yunis, Adel A
core +1 more source
Erythropoietic Protoporphyria in a Japanese Population
Acta Dermato-Venereologica, 2019 Erythropoietic protoporphyria is caused by a partial deficiency of ferrochelatase, which is the last enzyme in the heme biosynthesis pathway. In a typical erythropoietic protoporphyria, photosensitivity initially appears, following the first exposure to ...
Megumi Mizawa +4 more
doaj +1 more source
Advances in Agricultural Applications of Lignans
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.This graphical abstract presents lignans as green alternatives to chemical pesticides and antibiotics for agriculture and veterinary use. It illustrates their applications in plant protection (antifungal, insecticidal, herbicidal, fruit preservation) and aquaculture, classifies lignan subtypes from classic to complex forms, highlights limitations like ...
Kaida Li +5 more
wiley +1 more source
Liver transplantation for acute-on-chronic liver failure from erythropoietic protoporphyria [PDF]
Clinical and Molecular Hepatology, 2012 Erythropoietic protoporphyria (EPP) is an inherited disorder of the heme metabolic pathway that is characterized by accumulation of protoporphyrin in the blood, erythrocytes, and tissues, and cutaneous manifestations of photosensitivity, all resulting ...
Pyoung-Jae Park +9 more
doaj +1 more source
Human Frataxin: Iron and Ferrochelatase Binding Surface [PDF]
, 2007 The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein’s ability to serve as the iron chaperone during heme ...
Bradley, Patrick B. +6 more
core +1 more source