Results 61 to 70 of about 4,023 (167)
Journal of Biological Chemistry, 1994 Ferrochelatase (EC 4.99.1.1) catalyzes the terminal step in the heme biosynthetic pathway, the insertion of ferrous iron into protoporphyrin IX. Herein we report the expression, purification, and characterization of the mature processed form of human and mouse ferrochelatase in Escherichia coli JM109.
H A, Dailey, V M, Sellers, T A, Dailey
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Purification and characterization of chicken erythrocyte ferrochelatase [PDF]
Biochemical Journal, 1984 Ferrochelatase (EC 4.99.1.1) was purified 2000-fold to apparent homogeneity from isolated chicken erythrocyte mitochondria. The purified enzyme yields a single band on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis with an apparent Mr of 42 000.
J W, Hanson, H A, Dailey
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A cadmium stress-responsive gene AtFC1 confers plant tolerance to cadmium toxicity
BMC Plant Biology, 2017 Background Non-essential trance metal such as cadmium (Cd) is toxic to plants. Although some plants have developed elaborate strategies to deal with absorbed Cd through multiple pathways, the regulatory mechanisms behind the Cd tolerance are not fully ...
Jun Song +4 more
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Journal of Biophotonics, Volume 19, Issue 5, May 2026.This study demonstrates that 5‐ALA BL PDT induces greater levels of apoptosis in SCC cells in a wavelength‐, 5‐ALA dose‐, and temperature‐dependent manner, compared to 5‐ALA RL PDT, with higher concentrations of ALA and elevated temperatures stimulating the greatest apoptotic activity.
Julia Stolyar +5 more
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Induction of hepatic mitochondrial ferrochelatase by phenobarbital [PDF]
Biochemical and Biophysical Research Communications, 1970 Abstract Ferrochelatase, the catalyst for the last step in heme synthesis, is induced by chronic phenobarbital administration and this induction is prevented by the simultaneous administration of cycloheximide. This induction is revealed when the pyridine hemochrome was measured under anaerobic conditions but cobalt chelatase activity in hepatic ...
Hasegawa, E., Smith, C., Tephly, T. R.
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BMC Microbiology, 2019 Background Most species of Shewanella harbor two ferrochelatase paralogues for the biosynthesis of c-type cytochromes, which are crucial for their respiratory versatility.
Jingcheng Dai +7 more
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Localization of ferrochelatase in Plasmodium falciparum [PDF]
Biochemical Journal, 2004 Our previous studies have demonstrated de novo haem biosynthesis in the malarial parasite (Plasmodium falciparum and P. berghei). It has also been shown that the first enzyme of the pathway is the parasite genome-coded ALA (δ-aminolaevulinate) synthase localized in the parasite mitochondrion, whereas the second enzyme, ALAD (ALA dehydratase), is ...
Varadharajan, Sundaramurthy +3 more
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Molecular Genetics and Metabolism Reports, 2019 Erythropoietic protoporphyria (EPP) is an autosomal recessive deficiency in heme biosynthesis due to pathogenic variants in the ferrochelatase gene (FECH). Patients present with lifelong photosensitivity and potential liver disease.
Michele C. Kieke +9 more
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Health Science Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background Lead is a nonessential, toxic heavy metal that causes widespread environmental contamination, affecting humans, animals, plants, and ecosystems. Globally, an estimated 800 million children have blood lead levels (BLLs) above 5 µg/dL.
Gudisa Bereda
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Allocation of Heme is Differentially Regulated by Ferrochelatase Isoforms in Arabidopsis Cells
Frontiers in Plant Science, 2016 Heme is involved in various biological processes as a cofactor of hemoproteins located in various organelles. In plant cells, heme is synthesized by two isoforms of plastid-localized ferrochelatase, FC1 and FC2.
Nino Asuela Espinas +7 more
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