Results 41 to 50 of about 5,252 (212)
Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling. [PDF]
PLoS ONE, 2018 Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC). We tested the hypothesis that inhibition of vascular FECH
Bin Zhang +6 more
doaj +1 more source
Substrate interactions with human ferrochelatase [PDF]
Proceedings of the National Academy of Sciences, 2007 Ferrochelatase, the terminal enzyme in heme biosynthesis, catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX. Human ferrochelatase is a homodimeric, inner mitochondrial membrane-associated enzyme that possesses an essential [2Fe-2S] cluster.
Amy, Medlock +4 more
openaire +2 more sources
Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin
BMC Cancer, 2021 Background Photodynamic therapy with a photosensitizer such as protoporphyrin-IX, a light sensitive metabolite of heme synthesis, is a highly selective treatment for various carcinomas.
Bernhard Gillissen +3 more
doaj +1 more source
Erythropoietin signaling regulates heme biosynthesis
eLife, 2017 Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown ...
Jacky Chung +21 more
doaj +1 more source
Investigation of an atypical protoporphyric family in South Africa [PDF]
, 2010 Includes bibliographical references (leaves 171-184).Affected members of the family investigated in this dissertation presented with photosensitivity and raised red cell protoporphyrin concentrations, indicative of protoporphyria.
Haumann, Carel Eduard
core +1 more source
Crosstalk between metal ions in Bacillus subtilis ferrochelatase
, 2006 Ferrochelatase (EC 4.99.1.1), the terminal enzyme in the heme biosynthetic pathway, catalyzes the insertion of Fe2+ into protoporphyrin IX, generating heme.
Hansson, Mattias +6 more
core +2 more sources
Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review [PDF]
HemasphereAbstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Makis A, Saougou I, Hatzimichael E.
europepmc +2 more sources
Cloning of murine ferrochelatase. [PDF]
Proceedings of the National Academy of Sciences, 1991 Ferrochelatase (protoheme ferro-lyase, EC 4.99.1.1) catalyzes the last step in the heme biosynthetic pathway, the chelation of ferrous iron and protoporphyrin to form heme. The activity of ferrochelatase is deficient in the inherited disease protoporphyria.
D A, Brenner, F, Frasier
openaire +2 more sources
Pharmaceuticals, 2023 Erythropoietic protoporphyria (EPP) is a genetic disorder stemming from reduced ferrochelatase expression, the final enzyme in the pathway of heme biosynthesis.
Katelyn E. Madigan +4 more
doaj +1 more source
Screening Zinc Protoporphyrin-Forming Lactic Acid Bacteria to Replace Nitrite in Meat Products
FoodsSeventeen strains of LAB (lactic acid bacteria) were screened for their ability to form ZnPP (zinc protoporphyrin) by measuring fluorescence intensity.
Qianhui Yang +6 more
doaj +1 more source