Results 41 to 50 of about 4,768 (212)

Microglial SLC25A28 Knockout Mitigates Spinal Cord Injury in Mice by Inhibiting Heme Synthesis and Subsequent NOX2 Activation. [PDF]

CNS Neurosci Ther
Microglial SLC25A28 knockout reduces spinal cord injury by inhibiting mitochondrial iron accumulation and heme synthesis, leading to decreased NOX2 activation and neuroinflammation. This study reveals the SLC25A28‐heme‐NOX2 axis as a key regulator of microglial‐driven secondary damage after SCI.
Chen H, Guo S, Mi Y, Han R, Xi Y, Peng T, Fu L, Liu W, Ma R, Yu B, Zhang Y, Li L, Ye J, Gong S.   +13 more
europepmc   +2 more sources

Illuminating Dersimelagon: A Novel Agent in the Treatment of Erythropoietic Protoporphyria and X-Linked Protoporphyria

Pharmaceuticals, 2023
Erythropoietic protoporphyria (EPP) is a genetic disorder stemming from reduced ferrochelatase expression, the final enzyme in the pathway of heme biosynthesis.
Katelyn E. Madigan, Sean R. Rudnick, Matthew A. Agnew, Numra Urooj, Herbert L. Bonkovsky   +4 more
doaj   +1 more source

Screening Zinc Protoporphyrin-Forming Lactic Acid Bacteria to Replace Nitrite in Meat Products

Foods
Seventeen strains of LAB (lactic acid bacteria) were screened for their ability to form ZnPP (zinc protoporphyrin) by measuring fluorescence intensity.
Qianhui Yang, Zhiqiang Feng, Qian Chen, Haotian Liu, Qian Liu, Fangda Sun, Baohua Kong   +6 more
doaj   +1 more source

Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer

Molecules, 2011
Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme.
Jakub Golab, Kamil Bojarczuk, Małgorzata Wańczyk, Magdalena Winiarska, Magdalena Gabrysiak, Małgorzata Firczuk, Angelika Muchowicz, Małgorzata Wachowska   +7 more
doaj   +1 more source

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis

Haematologica, 2019
Loss-of-function mutations in the ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, ABCB7, cause X-linked sideroblastic anemia with ataxia, a phenotype that remains largely unexplained by the proposed role of ABCB7 in exporting ...
Nunziata Maio, Ki Soon Kim, Gregory Holmes-Hampton, Anamika Singh, Tracey A. Rouault   +4 more
doaj   +1 more source

Resonance Raman spectroscopic examination of ferrochelatase-induced porphyrin distortion

, 2011
Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, catalyzes the insertion of ferrous iron into protoporphyrin IX to give heme. Resonance Raman spectroscopy has been instrumental in defining the distortion (mode and extent) of the ...
Gloria C. Ferreira, Al-Karadaghi, Salam, Ferreira, Gloria C., Franco, Ricardo, Salam Al-Karadaghi, Ricardo Franco   +5 more
core   +1 more source

Erythropoietic protoporphyria: case reports for clinical and therapeutic hints

Italian Journal of Pediatrics, 2023
Background Erythropoietic protoporphyria is a rare disorder which represents an important health problem in children, causing painful photosensitivity. Little is known on the correlation between genetic profile and clinical manifestations.
Cristina Tumminelli, Francesca Burlo, Serena Pastore, Giovanni Maria Severini, Irene Berti, Stefano Marchini, Davide Zanon, Eleonora De Martino, Alberto Tommasini   +8 more
doaj   +1 more source

Ultrasound intensification of Ferrochelatase extraction from pork liver as a strategy to improve ZINC-protoporphyrin formation

Ultrasonics Sonochemistry, 2021
The enzyme Ferrochelatase (FeCH), which is naturally present in pork liver, catalyses the formation of Zinc-protoporphyrin (ZnPP), a natural pigment responsible for the typical color of dry-cured Italian Parma ham.
B. Abril, E.A. Sanchez-Torres, R. Bou, J.V. Garcia-Perez, J. Benedito   +4 more
doaj   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Metal Ion Substrate Inhibition of Ferrochelatase [PDF]

Journal of Biological Chemistry, 2008
Ferrochelatase catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme. Robust kinetic analyses of the reaction mechanism are complicated by the instability of ferrous iron in aqueous solution, particularly at alkaline pH values. At pH 7.00 the half-life for spontaneous oxidation of ferrous ion is approximately 2 min in the absence ...
Gregory A, Hunter, Matthew P, Sampson, Gloria C, Ferreira   +2 more
openaire   +2 more sources