Results 21 to 30 of about 4,768 (212)

Predictive biomarkers for 5‐ALA‐PDT can lead to personalized treatments and overcome tumor‐specific resistances

Cancer Reports, 2022
Background Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies.
Maria Mastrangelopoulou, Mantas Grigalavicius, Tine H. Raabe, Ellen Skarpen, Petras Juzenas, Qian Peng, Kristian Berg, Theodossis A. Theodossiou   +7 more
doaj   +1 more source

Application of a non-invasive tool and identification of genetic markers in swine to enhance ham quality: a preliminary study

Animal, 2023
A genome-wide association study (GWAS) was performed as a preliminary step to identify regions potentially related to ham quality traits. In this research, genomic information was obtained from 238 commercial hybrid pigs utilising the GeneSeek® Genomic ...
J. Vegni, M. Zappaterra, R. Davoli, R. Virgili, N. Simoncini, C. Schivazappa, A. Cilloni, P. Zambonelli   +7 more
doaj   +1 more source

Barley Plants Overexpressing Ferrochelatases (HvFC1 and HvFC2) Show Improved Photosynthetic Rates and Have Reduced Photo-Oxidative Damage under Drought Stress than Non-Transgenic Controls

Agronomy, 2020
We investigated the roles of two Ferrochelatases (FCs), which encode the terminal enzyme for heme biosynthesis, in drought and oxidative stress tolerance in model cereal plant barley (Hordeum vulgare).
Dilrukshi S. K. Nagahatenna, Boris Parent, Everard J. Edwards, Peter Langridge, Ryan Whitford   +4 more
doaj   +1 more source

Ferrochelatase activity of plant frataxin [PDF]

Biochimie, 2019
Frataxin plays a key role in cellular iron homeostasis of different organisms. It is engaged in several activities at the FeS cluster assembly machinery and it is also involved in heme biosynthesis. In plants, two genes encoding ferrochelatases (FC1 and FC2) catalyze the incorporation of iron into protoporphyrin IX in the last stage of heme synthesis ...
Alejandro M. Armas, Manuel Balparda, Agustina Terenzi, Maria V. Busi, Maria A. Pagani, Diego F. Gomez-Casati   +5 more
openaire   +3 more sources

Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase [PDF]

, 2010
Ferrochelatase catalyzes the insertion of Fe(2+) into protoporphyrin IX. The enzymatic product heme (protoheme IX) is a well-known cofactor in a wide range of proteins.
Salam Al-Karadaghi, Rajan, Sreekanth,, Rigby, Stephen E J, Tobias Karlberg, Sreekanth Rajan, Mats Hansson, Hansson, Mattias,, Karlberg, Tobias, Söderberg, Christopher, Warren, MJ, Al-Karadaghi, Salam,, Söderberg, Christopher A. G., Hansson, MD, Al-Karadaghi, Salam, Rigby, SEJ, Mattias D. Hansson, Al-Karadaghi, S, Karlberg, Tobias,, Rigby, Stephen E.J., Söderberg, Christopher,, Hansson, Mattias D., Hansson, Mattias, Warren, Martin J, Karlberg, T,, Hansson, M, Hansson, Mats, Rajan, Sreekanth, Christopher A. G. Söderberg, Rigby, Stephen E. J., Warren, Martin J., Martin J. Warren, Stephen E. J. Rigby, Lund University., Söderberg, CAG, Söderberg, Christopher A.G., Rajan, S   +35 more
core   +1 more source

Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase

Journal of the Formosan Medical Association, 2014
Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of oral precancerous and cancerous lesions. This in vitro study tried to examine whether the SCC4 cell killing by ALA-PDT was enhanced by pretreatment of ...
Deng-Fu Yang, Jeng-Woei Lee, Hsin-Ming Chen, Zheng Huang, Yih-Chih Hsu   +4 more
doaj   +1 more source

Altering Tetrapyrrole Biosynthesis by Overexpressing Ferrochelatases (Fc1 and Fc2) Improves Photosynthetic Efficiency in Transgenic Barley

Agronomy, 2020
Ferrochelatase (FC) is the terminal enzyme of heme biosynthesis. In photosynthetic organisms studied so far, there is evidence for two FC isoforms, which are encoded by two genes (FC1 and FC2).
Dilrukshi S. K. Nagahatenna, Jingwen Tiong, Everard J. Edwards, Peter Langridge, Ryan Whitford   +4 more
doaj   +1 more source

Liver Transplantation and Other Hepatically Directed Therapies Do Not Change the Biochemical Phenotype nor Halt Progression of Leukodystrophy due to Biallelic <i>HMBS</i> Variants: A Case Report. [PDF]

JIMD Rep
ABSTRACT Leukodystrophy due to biallelic HMBS variants is a rare condition distinct from acute intermittent porphyria (AIP). It is characterised by progressive leukoencephalopathy rather than acute attacks of neurovisceral symptoms. We report the ongoing clinical progression of a patient with leukodystrophy due to homozygous variants in HMBS [c.251C>A,
Clark J, Smith J, Leong Y, Cronin V, Winship I, Ross G, Fazio T.   +6 more
europepmc   +2 more sources

Ferrochelatase of Rhodopseudomonas spheroides [PDF]

Biochemical Journal, 1970
Extracts of Rhodopseudomonas spheroides contain two ferrochelatases: one is soluble and forms metalloporphyrins from deuteroporphyrin and haematoporphyrin; the other is particulate and forms metalloporphyrins from protoporphyrin, mesoporphyrin, deuteroporphyrin and haematoporphyrin.
M S, Jones, O T, Jones
openaire   +2 more sources

Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase

Redox Biology, 2021
Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned between the cytosol and mitochondria, with the first and final steps taking place in the ...
Jonathan V. Dietz, Mathilda M. Willoughby, Robert B. Piel, III, Teresa A. Ross, Iryna Bohovych, Hannah G. Addis, Jennifer L. Fox, William N. Lanzilotta, Harry A. Dailey, James A. Wohlschlegel, Amit R. Reddi, Amy E. Medlock, Oleh Khalimonchuk   +12 more
doaj   +1 more source