Results 21 to 30 of about 4,023 (167)
Ferrochelatase activity of plant frataxin [PDF]
Biochimie, 2019 Frataxin plays a key role in cellular iron homeostasis of different organisms. It is engaged in several activities at the FeS cluster assembly machinery and it is also involved in heme biosynthesis. In plants, two genes encoding ferrochelatases (FC1 and FC2) catalyze the incorporation of iron into protoporphyrin IX in the last stage of heme synthesis ...
Alejandro M. Armas +5 more
openaire +3 more sources
Journal of the Formosan Medical Association, 2014 Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of oral precancerous and cancerous lesions. This in vitro study tried to examine whether the SCC4 cell killing by ALA-PDT was enhanced by pretreatment of ...
Deng-Fu Yang +4 more
doaj +1 more source
Agronomy, 2020 Ferrochelatase (FC) is the terminal enzyme of heme biosynthesis. In photosynthetic organisms studied so far, there is evidence for two FC isoforms, which are encoded by two genes (FC1 and FC2).
Dilrukshi S. K. Nagahatenna +4 more
doaj +1 more source
Redox Biology, 2021 Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned between the cytosol and mitochondria, with the first and final steps taking place in the ...
Jonathan V. Dietz +12 more
doaj +1 more source
Ferrochelatase of Rhodopseudomonas spheroides [PDF]
Biochemical Journal, 1970 Extracts of Rhodopseudomonas spheroides contain two ferrochelatases: one is soluble and forms metalloporphyrins from deuteroporphyrin and haematoporphyrin; the other is particulate and forms metalloporphyrins from protoporphyrin, mesoporphyrin, deuteroporphyrin and haematoporphyrin.
M S, Jones, O T, Jones
openaire +2 more sources
Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report
Liver Research, 2022 Erythropoietic protoporphyria (EPP) is a rare inherited disease caused by partial deficiency activity of the enzyme ferrochelatase (FECH), resulting in excessive accumulation of protoporphyrin IX in erythrocyte and tissues. Here, we report a patient with
Hanqing Huang +3 more
doaj +1 more source
Liver Transplantation and Other Hepatically Directed Therapies Do Not Change the Biochemical Phenotype nor Halt Progression of Leukodystrophy due to Biallelic <i>HMBS</i> Variants: A Case Report. [PDF]
JIMD RepABSTRACT Leukodystrophy due to biallelic HMBS variants is a rare condition distinct from acute intermittent porphyria (AIP). It is characterised by progressive leukoencephalopathy rather than acute attacks of neurovisceral symptoms. We report the ongoing clinical progression of a patient with leukodystrophy due to homozygous variants in HMBS [c.251C>A,
Clark J +6 more
europepmc +2 more sources
Ferrochelatase of spinach chloroplasts [PDF]
Biochemical Journal, 1968 Spinach chloroplasts catalyse the incorporation of Fe2+ into protoporphyrin, mesoporphyrin and deuteroporphyrin to form the corresponding haems. This ferrochelatase activity was detected by pyridine haemochrome formation with acetone-dried powders of chloroplasts, or from the formation of [59Fe]haems by intact chloroplasts. Decreasing the mitochondrial
openaire +2 more sources
Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice1
Journal of Lipid Research, 2001 Erythropoietic protoporphyria (EPP) is an inherited disorder of heme synthesis caused by deficiency of the mitochondrial enzyme ferrochelatase. EPP in humans is associated with liver disease, hypertriglyceridemia, and a low level of high density ...
Vincent W. Bloks +9 more
doaj +1 more source
Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling. [PDF]
PLoS ONE, 2018 Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC). We tested the hypothesis that inhibition of vascular FECH
Bin Zhang +6 more
doaj +1 more source