Results 21 to 30 of about 5,252 (212)
Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria
Frontiers in Cell and Developmental Biology, 2022 Porphyrin and iron are ubiquitous and essential for sustaining life in virtually all living organisms. Unlike iron, which exists in many forms, porphyrin macrocycles are mostly functional as metal complexes. The iron-containing porphyrin, heme, serves as
Chibuike David Obi +5 more
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Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells
Life, 2023 Heme is an essential cofactor for multiple cellular processes in most organisms. In developing erythroid cells, the demand for heme synthesis is high, but is significantly lower in non-erythroid cells.
Chibuike David Obi +4 more
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Protoporphyrin IX Binds to Iron(II)-Loaded and to Zinc-Loaded Human Frataxin
Life, 2023 (1) Background: Human frataxin is an iron binding protein that participates in the biogenesis of iron sulfur clusters and enhances ferrochelatase activity.
Ganeko Bernardo-Seisdedos +4 more
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Basophilic Stippling and Ringed Sideroblasts Revealing Hidden Lead Poisoning in Refractory Microcytic Anemia [PDF]
EJHaemeJHaem, Volume 7, Issue 5, October 2026.
Gao H, Dai M, Zhou J, Li X, Ning Y.
europepmc +2 more sources
Iron, Heme Synthesis and Erythropoietic Porphyrias: A Complex Interplay
Metabolites, 2021 Erythropoietic porphyrias are caused by enzymatic dysfunctions in the heme biosynthetic pathway, resulting in porphyrins accumulation in red blood cells.
Antoine Poli +6 more
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In Campylobacter jejuni, a new type of chaperone receives heme from ferrochelatase
Frontiers in Genetics, 2023 Intracellular heme formation and trafficking are fundamental processes in living organisms. Bacteria and archaea utilize three biogenesis pathways to produce iron protoporphyrin IX (heme b) that diverge after the formation of the common intermediate ...
Jordi Zamarreño Beas +6 more
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Iron Homeostasis and Liver Diseases. [PDF]
J Cell Mol MedABSTRACT Iron is an essential micronutrient whose ability to cycle between ferric (Fe3+) and ferrous (Fe2+) states makes it crucial for physiological processes, including oxygen transport, DNA synthesis, and oxidative phosphorylation. However, because both deficiency and excess can cause severe pathology, precise regulation is critical. The liver plays
Yang P +6 more
europepmc +2 more sources
Ferrochelatase regulates retinal neovascularization [PDF]
The FASEB Journal, 2020 Abstract Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo. But FECH has not been explored in retinal neovascularization, which underlies diseases like proliferative diabetic ...
Sardar Pasha Sheik Pran Babu +2 more
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Cancer Reports, 2022 Background Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies.
Maria Mastrangelopoulou +7 more
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Animal, 2023 A genome-wide association study (GWAS) was performed as a preliminary step to identify regions potentially related to ham quality traits. In this research, genomic information was obtained from 238 commercial hybrid pigs utilising the GeneSeek® Genomic ...
J. Vegni +7 more
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