Refolding and enzyme kinetic studies on the ferrochelatase of the cyanobacterium Synechocystis sp. PCC 6803. [PDF]
PLoS ONE, 2013 Heme is a cofactor for proteins participating in many important cellular processes, including respiration, oxygen metabolism and oxygen binding. The key enzyme in the heme biosynthesis pathway is ferrochelatase (protohaem ferrolyase, EC 4.99.1.1), which ...
Patrik Storm +3 more
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Porphyromonas gingivalis produces a functional HemH ferrochelatase important for its survival in a heme-limited environment [PDF]
Scientific ReportsPorphyromonas gingivalis, the keystone pathogen responsible for dysbiosis in the oral microbiome, the development of periodontal diseases, and the contribution to systemic comorbidities, is a heme auxotroph.
Michał Śmiga +3 more
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Induction of hepatic mitochondrial ferrochelatase by phenobarbital [PDF]
Biochemical and Biophysical Research Communications, 1970 Ferrochelatase, the catalyst for the last step in heme synthesis, is induced by chronic phenobarbital administration and this induction is prevented by the simultaneous administration of cycloheximide.
Hasegawa, E., Smith, C., Tephly, T. R.
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The importance of porphyrin distortions for the ferrochelatase reaction. [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2003 Ferrochelatase is the terminal enzyme in haem biosynthesis, i.e. the enzyme that inserts a ferrous ion into the porphyrin ring. Suggested reaction mechanisms for this enzyme involve a distortion of the porphyrin ring when it is bound to the enzyme.
Ulf Ryde +5 more
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FECH, a novel metabolic target influencing CAR T-cell phenotype and function [PDF]
Biomarker ResearchRecent phase I/II clinical trials have demonstrated that chimeric antigen receptor (CAR) T cells targeting the disialogangliosade GD2 represent a promising therapeutic option for pediatric patients with relapsed or refractory high-risk neuroblastoma (NB).
Marsha Pellegrino +23 more
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Ferrochelatase is a therapeutic target for ocular neovascularization
EMBO Molecular Medicine, 2017 Ocular neovascularization underlies major blinding eye diseases such as “wet” age‐related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, resistant and refractory patient ...
Halesha D Basavarajappa +16 more
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Erythropoietic protoporphyria linked to intricate double heterozygous mutations in theFECH gene: a case report and literature review [PDF]
Orphanet Journal of Rare DiseasesBackground Erythropoietic protoporphyria is an inherited disorder characterized by mutations in the FECH gene, which encodes the enzyme ferrous chelatase.
Hongli Xiong +4 more
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Challenges in the pathological diagnosis of erythropoietic protoporphyria: a case report [PDF]
Frontiers in MedicineBackgroundErythropoietic protoporphyria (EPP) is a rare autosomal recessive disorder caused by mutations in the FECH gene, leading to ferrochelatase deficiency and the accumulation of protoporphyrin in various organs.
Tingting Yang +3 more
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Regulation of the expression of ferrochelatase in a murine model of diabetes mellitus type I [PDF]
Biochemistry and Biophysics ReportsBackground: Diabetes produces changes on cellular hemeprotein metabolism. The last enzyme of heme biosynthetic pathway is ferrochelatase (FECH), an enzyme that catalyzes the insertion of ferrous ion into protoporphyrin IX to produce heme. The aim of this
Leda María Oliveri +2 more
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New FLU mutant alleles point to new insights into singlet oxygen-mediated signal transduction. [PDF]
New PhytolNew Phytologist, Volume 252, Issue 4, Page 1354-1356, November 2026.
Grimm B.
europepmc +2 more sources