Results 11 to 20 of about 4,768 (212)

Induction of hepatic mitochondrial ferrochelatase by phenobarbital [PDF]

Biochemical and Biophysical Research Communications, 1970
Abstract Ferrochelatase, the catalyst for the last step in heme synthesis, is induced by chronic phenobarbital administration and this induction is prevented by the simultaneous administration of cycloheximide. This induction is revealed when the pyridine hemochrome was measured under anaerobic conditions but cobalt chelatase activity in hepatic ...
Hasegawa, E., Smith, C., Tephly, T. R.
openaire   +4 more sources

The coding sequence of the bovine ferrochelatase gene

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1995
The amino acid code and surrounding regions in the bovine ferrochelatase gene were amplified by a combination of reverse transcriptase PCR and vectorette PCR and sequenced. The bovine code was 86% homologous to the human ferrochelatase code but was altered at a position corresponding to the presumed human initiator codon.
Shibuya, Hisashi, Nonneman, Dan, Tamassia, Manoel, Allphin, Owen L., Johnson, Gary S.   +4 more
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Ferrochelatase is a therapeutic target for ocular neovascularization

EMBO Molecular Medicine, 2017
Ocular neovascularization underlies major blinding eye diseases such as “wet” age‐related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, resistant and refractory patient ...
Halesha D Basavarajappa, Rania S Sulaiman, Xiaoping Qi, Trupti Shetty, Sardar Sheik Pran Babu, Kamakshi L Sishtla, Bit Lee, Judith Quigley, Sameerah Alkhairy, Christian M Briggs, Kamna Gupta, Buyun Tang, Mehdi Shadmand, Maria B Grant, Michael E Boulton, Seung‐Yong Seo, Timothy W Corson   +16 more
doaj   +3 more sources

The importance of porphyrin distortions for the ferrochelatase reaction [PDF]

JBIC Journal of Biological Inorganic Chemistry, 2003
Ferrochelatase is the terminal enzyme in haem biosynthesis, i.e. the enzyme that inserts a ferrous ion into the porphyrin ring. Suggested reaction mechanisms for this enzyme involve a distortion of the porphyrin ring when it is bound to the enzyme. We have examined the energetics of such distortions using various theoretical calculations.
Sigfridsson, Emma, Ryde, Ulf
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Lead Poisoning Revealed by Unexplained Abdominal Pain and Anemia in a Young Adult: A Diagnostic Challenge. [PDF]

Clin Case Rep
ABSTRACT Lead poisoning should be considered in patients presenting with unexplained anemia and abdominal pain, even without clear environmental or occupational exposure. Recognizing classic signs such as Burton's line and basophilic stippling enables timely diagnosis and effective chelation therapy.
Eichler J, Albrecht S, Huber LC.
europepmc   +2 more sources

Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes reactive oxygen species production and iron ...
Smuder AJ, Doerr V, Jacintho Moritz CE, Li J, Nguyen BL.   +4 more
europepmc   +2 more sources

Iron, Heme Synthesis and Erythropoietic Porphyrias: A Complex Interplay

Metabolites, 2021
Erythropoietic porphyrias are caused by enzymatic dysfunctions in the heme biosynthetic pathway, resulting in porphyrins accumulation in red blood cells.
Antoine Poli, Caroline Schmitt, Boualem Moulouel, Arienne Mirmiran, Hervé Puy, Thibaud Lefèbvre, Laurent Gouya   +6 more
doaj   +1 more source

In Campylobacter jejuni, a new type of chaperone receives heme from ferrochelatase

Frontiers in Genetics, 2023
Intracellular heme formation and trafficking are fundamental processes in living organisms. Bacteria and archaea utilize three biogenesis pathways to produce iron protoporphyrin IX (heme b) that diverge after the formation of the common intermediate ...
Jordi Zamarreño Beas, Marco A. M. Videira, Val Karavaeva, Frederico M. Lourenço, Mafalda R. Almeida, Filipa Sousa, Lígia M. Saraiva   +6 more
doaj   +1 more source

Ferrochelatase regulates retinal neovascularization [PDF]

The FASEB Journal, 2020
Abstract Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo. But FECH has not been explored in retinal neovascularization, which underlies diseases like proliferative diabetic ...
Sardar Pasha Sheik Pran Babu, Darcy White, Timothy W. Corson   +2 more
openaire   +3 more sources

Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron-sulphur cluster assembly pathways. [PDF]

J Physiol
Abstract figure legend Altered iron handling and mitochondrial pathways in FGR placentas. Placental tissue from FGR pregnancies showed increased expression of iron importers, transferrin and divalent metal transporter 1, and decreased expression of the iron exporter ferroportin, suggesting that the FGR placenta is retaining iron to meet its own ...
Botha VB, Murray HC, Acharya S, Pringle KG, Smith R, Fisher JJ.   +5 more
europepmc   +2 more sources