Results 121 to 130 of about 5,252 (212)

Structures of catalytic residues of human ferrochelatase and results of prediction.

, 2012
(A) Structures of catalytic residues, H263, H341, and E343, of human ferrochelatase (PDB id: 1 hrk). Side chain structures of the catalytic residues are shown as ball-and-stick.
Shao-Wei Huang (125737), Yu-Tung Chien (125735)   +1 more
core   +1 more source

Exploring the Antiangiogenic and Anti-Inflammatory Potential of Homoisoflavonoids: Target Identification Using Biotin Probes

Biomolecules
Chemical proteomics using biotin probes of natural products have significantly advanced our understanding of molecular targets and therapeutic potential.
Xiang Fei, Sangil Kwon, Jinyoung Jang, Minyoung Seo, Seongwon Yu, Timothy W. Corson, Seung-Yong Seo   +6 more
doaj   +1 more source

GLRX5 mutations impair heme biosynthetic enzymes ALA synthase 2 and ferrochelatase in Human congenital sideroblastic anemia

, 2019
International audienceNon-syndromic microcytic congenital sideroblastic anemia (cSA) is predominantly caused by defective genes encoding for either ALAS2, the first enzyme of heme biosynthesis pathway or SLC25A38, the mitochondrial importer of glycine ...
Moulouel, Boualem, Kannengiesser, Caroline, Daher, Raed, Mansouri, Abdellah, Martelli, Alain, Manceau, Hana, Bayart, Sophie, Puy, Hervé, Gouya, Laurent, Callebaut, Isabelle, Karim, Zoubida   +10 more
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Ferrochelatase and Magnesiumchelatase: Metal chelation studied with mutants

, 2003
Magnesium chelatase and ferrochelatase are two very important enzymes, which are involved in chlorophyll and heme biosynthesis, respectively. They both use protoporphyrin IX as substrate but magnesium chelatase inserts a magnesium ion whereas ...
Olsson, Ulf
core  

Identification and Characterization of Solvent-Filled Channels in Human Ferrochelatase

, 2016
Ferrochelatase catalyzes the formation of protoheme from two potentially cytotoxic products, iron and protoporphyrin IX. While much is known from structural and kinetic studies on human ferrochelatase of the dynamic nature of the enzyme during catalysis ...
Amy E. Medlock (784951), Wided Najahi-Missaoui (2066371), Jessica R. O’Brien (2066353), Teresa A. Ross (2066359), William N. Lanzilotta (2066362), Harry A. Dailey (2066356), Joseph Burch (2066368), Tamara A. Dailey (2066365)   +7 more
core   +1 more source

Case Report: Cholestatic liver disease in the course of erythropoietic protoporphyria associated with renal hypodysplasia and atrial septal defect

Frontiers in Pediatrics
Erythropoietic protoporphyria (EPP) is an autosomal recessive disorder of the heme biosynthesis pathway caused by pathogenic variants in FECH gene resulting in a decreased activity of ferrochelatase.
Patryk Lipiński, Agnieszka Lipniacka, Maja Klaudel-Dreszler, Lidia Ziółkowska, Grażyna Kostrzewa, Edyta Odnoczko, Robert Wasilewski, Rafał Płoski, Anna Tylki-Szymańska   +8 more
doaj   +1 more source

Complex formation between protoporphyrinogen IX oxidase and ferrochelatase during haem biosynthesis in Thermosynechococcus elongatus.

, 2008
International audienceDuring haem and chlorophyll biosynthesis, flavin-dependent protoporphyrinogen IX oxidase catalyses the six-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX.
Heinemann, Ilka Ursula, Koch, Michael, Manfred Rohde, Rohde, Manfred, Martina Jahn, Dieter Jahn, Jahn, Martina, Jahn, Dieter, Ilka Ursula Heinemann, Michael Koch, Masoumi, Ava, Ava Masoumi   +11 more
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Unraveling the potential of zinc protoporphyrin-forming lactic acid bacteria for replacing nitrite and their role in quality characteristics of Harbin dry sausage

Food Chemistry: X
This study evaluated the effects of zinc protoporphyrin-producing lactic acid bacteria specifically Weissella viridescens JX11, Weissella viridescens MDJ8, and Lactobacillus pentosus Q on nitrite substitution and the quality characteristics of Harbin dry
Qianhui Yang, Zhiqiang Feng, Yaru Yuan, Xiufang Xia, Qian Liu, Qian Chen, Baohua Kong   +6 more
doaj   +1 more source

Mitochondrial localization of functional ferrochelatase from Plasmodium falciparum

, 2009
In the malarial parasite, enzymes of heme-biosynthetic pathway are distributed in different cellular compartments. The site of localization of ferrochelatase in the malarial parasite is crucial, since it will decide the ultimate site of heme synthesis.
Rangarajan, Pundi N, Nagaraj, Viswanathan Arun, Rangarajan, Pundi N., Prasad, Dasari, Padmanaban, Govindarajan, Govindarajan Padmanaban, Viswanathan Arun Nagaraj, Dasari Prasad, Pundi N. Rangarajan   +8 more
core   +1 more source

Erythropoietic protoporphyria and early onset of cholestasis

The Turkish Journal of Pediatrics, 2012
Erythropoietic protoporphyria (EPP) is an inherited defect of mitochondrial ferrochelatase. This defect results in accumulation of protoporphyrin in erythrocytes, plasma, liver, and skin, which causes severe photosensitivity.
Mani Jeh Khalili, Fatemeh Farahmand, Armin Hirbod-Mobarakeh, Azizollah Yousefi, Soheila Sotoudeh, Maryam Monajemzadeh, Anahita Razaghian, Nima Rezaei   +7 more
doaj