Results 121 to 130 of about 17,809 (256)

Altered iron metabolism is part of the choroid plexus response to peripheral inflammation. [PDF]

, 2009
Iron is essential for normal cellular homeostasis but in excess promotes free radical formation and is detrimental. Therefore, iron metabolism is tightly regulated.
Coppola, Giovanni, Falcão, Ana M., Geschwind, Daniel H., Marques, Fernanda, Neves, Margarida Correia, Palha, Joana Almeida, Sousa, João Carlos, Sousa, Nuno   +7 more
core   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

First Case Report of Precursor‐Targeted Immune‐Mediated Anaemia in a Dog From Italy Lacking Rubriphagocytosis and With Severe Hyperferraemia: Diagnosis, Treatment, and Clinical Outcome

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
ABSTRACT Precursor‐targeted immune‐mediated anaemia (PIMA) is an uncommon and poorly understood cause of persistent non‐regenerative anaemia in dogs and cats, characterised by ineffective erythropoiesis and frequently associated with rubriphagocytosis (RP) in bone marrow samples.
Souad Nasar, Annamaria Uva, Giovanna Girardi, Giulia Tanas, Stefano Ciccarelli, Andrea Zatelli, Maria Alfonsa Cavalera, Floriana Gernone   +7 more
wiley   +1 more source

Adaptive Significance of Nickel Hyperaccumulation by Plants

Ecological Research, Volume 41, Issue 2, March 2026.
Metal hyperaccumulation may enhance plant fitness through multiple, non‐exclusive mechanisms, including elemental defense against herbivores and pathogens, altered pollinator interactions, and increased reproductive performance in metal‐rich soils. Metals may also affect plant–plant interactions via elemental allelopathy and improve stress tolerance ...
Molly E. Waddington, Robert S. Boyd, Nishanta Rajakaruna   +2 more
wiley   +1 more source

Iron Metabolism: From Health to Disease [PDF]

, 2014
Background Iron is vital for almost all living organisms by participating in a wide range of metabolic processes. However, iron concentration in body tissues must be tightly regulated since excessive iron may lead to microbial infections or cause tissue
Fernandes, Rúben, Oliveira, Fernando, Rocha, Sara   +2 more
core   +1 more source

Expression and cellular localization of hepcidin mRNA and protein in normal rat brain. [PDF]

, 2015
BACKGROUND: Hepcidin is a peptide hormone belonging to the defensin family of cationic antimicrobial molecules that has an essential role in systemic iron homeostasis. The peptide is synthesised by hepatocytes and transported in the circulation to target
Adrian Bomford, Animesh Alexander Raha, Jing-Wei Zhao, Raha-Chowdhury, Ruma, Ruma Raha-Chowdhury, Serhiy Forostyak, Simon Russell William Stott   +6 more
core   +1 more source

ALDH2 Mediated Ferroptosis Regulation in Ischemia–Reperfusion Injury

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Ischemia–reperfusion injury (IRI) is a common complication in diverse clinical settings, including myocardial infarction, stroke, organ transplantation and major surgery. Its pathological core lies in the metabolic disruption caused by blood flow cessation, followed by oxidative stress, inflammatory cascades and cell death upon reperfusion ...
Liang Han, Wen Zhai
wiley   +1 more source

Mycobacteria-induced anaemia revisited : a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin [PDF]

, 2011
Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron ...
Alves, Cláudio Nunes, Appelberg, Rui, Gomes, M. Salomé, Gomes, Sandro S., Muckenthaler, Martina U., Neves, João V., Neves, Margarida Correia, Pereira, Sandra Gomes, Rodrigues, Pedro, Sanchez, Mayka, Stolte, Jens   +10 more
core   +1 more source

Sex and Diet Biased Effect of L‐DOPA on Iron Accumulation in the Ventral Midbrain

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Dietary iron status and antiparkinson treatments influence regulation in the ventral midbrain. Male and female Long‐Evans rats were placed on iron‐adequate (IA), iron‐deficient (ID), or iron‐repletion (IR) diets and treated with L‐DOPA, selegiline, or vehicle.
Rebecka O. Serpa, Emily Tufano, Kondaiah Palsa, Timothy B. Helmuth, Sara Mills‐Huffnagle, Mathias Kant, James R. Connor   +6 more
wiley   +1 more source

What’s Important and New in Hemochromatosis?

Clinical Hematology International, 2020
Major advances in the understanding of genetic iron overload have led to a clarification of the nosology and terminology of the related diseases. The term hemochromatosis should be reserved to the entities where iron overload is related to hepcidin ...
Pierre Brissot, Eolia Brissot
doaj   +1 more source