Results 61 to 70 of about 17,727 (258)
Frontiers in Cellular and Infection Microbiology, 2022 BackgroundPneumonia is often elicited by bacteria and can be associated with a severe clinical course, respiratory failure and the need for mechanical ventilation.
Philipp Grubwieser +10 more
doaj +1 more source
Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages. [PDF]
, 2014 Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system.
Alessandra Frioni +27 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Role of Ferroportin in Macrophage-Mediated Immunity [PDF]
Infection and Immunity, 2010 ABSTRACT Perturbations in iron metabolism have been shown to dramatically impact host response to infection. The most common inherited iron overload disorder results from defects in the HFE gene product, a major histocompatibility complex class I-like protein that interacts with transferrin receptors.
Johnson, Erin E. +4 more
openaire +3 more sources
The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]
, 2011 Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra +9 more
core +1 more source
Iron metabolism and laboratory testing for iron status [PDF]
Medicinski Podmladak, 2016 Under normal circumstances, 1-2 mg of iron enters and leaves the body each day. Iron is absorbed in the duodenum, as heme and non-heme iron (Fe+2). Due to its ability to participate in redox-reactions, iron possesses toxic properties.
Ćorić Vesna
doaj +1 more source
Advanced Science, EarlyView.Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu +11 more
wiley +1 more source
Genetic and clinical heterogeneity of ferroportin disease [PDF]
British Journal of Haematology, 2005 SummaryFerroportin is encoded by the SLC40A1 gene and mediates iron export from cells by interacting with hepcidin. SLC40A1 gene mutations are associated with an autosomal type of genetic iron overload described as haemochromatosis type 4, or HFE4 (Online Mendelian Inheritance in Man number 606069), or ferroportin disease. We report three families with
L, Cremonesi +12 more
openaire +4 more sources
Hepcidin antagonists for potential treatments of disorders with hepcidin excess [PDF]
, 2014 5noThe discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide.
Maria Regoni +4 more
core +2 more sources
Journal of Clinical and Diagnostic Research, 2013 Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red
Subha Palaneeswari M. +4 more
doaj +1 more source