Results 11 to 20 of about 109,999 (379)

The diversified role of mitochondria in ferroptosis in cancer

Cell Death and Disease, 2023
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012.
Yu’e Liu, Shiping Lu, Lei-lei Wu, Liang Yang, Lixue Yang, Jinghan Wang   +5 more
doaj   +2 more sources

The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis [PDF]

Nature, 2019
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
K. Bersuker, Joseph M. Hendricks, Zhipeng Li, Leslie Magtanong, Breanna Ford, P. Tang, Melissa A. Roberts, Bingqi Tong, T. Maimone, R. Zoncu, M. Bassik, Daniel K. Nomura, S. Dixon, James A. Olzmann   +13 more
semanticscholar   +3 more sources

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy [PDF]

Nature, 2019
Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin–granzyme and Fas–Fas ligand ...
Weimin Wang, Michael D. Green, Jae Eun Choi, Miguel A. Gijón, Paul D. Kennedy, Jeffrey Johnson, Peng Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gaopeng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, Wei Gu, Rebecca Liu, Theodore S. Lawrence, Candice Lamb, Yuri Tanno, Marcin Cieślik, Everett Stone, George Georgiou, Timothy A. Chan, Arul M. Chinnaiyan, Weiping Zou   +29 more
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Targeting ferroptosis opens new avenues for the development of novel therapeutics

Signal Transduction and Targeted Therapy, 2023
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation.
Shumin Sun, Jie Shen, Jianwei Jiang, Fudi Wang, Junxia Min   +4 more
doaj   +2 more sources

Ferroptosis in health and disease. [PDF]

Redox Biology
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane ...
Alborzinia, Hamed, Amen, Vera, Ayton, Scott, Barayeu, Uladzimir, Bartelt, Alexander, Bayir, Hülya, Bebber, Christina, Berndt, Carsten, Birsoy, Kivanc, Brabletz, Simone, Brabletz, Thomas, Brown, Ashley, Bruneau, Alix, Brüne, Bernhard, Bulli, Giorgia, Böttcher, Jan, Chen, Quan, Conrad, Marcus, DeNicola, Gina, Dick, Tobias, Distéfano, Ayelén, Dixon, Scott, Engler, Jan, Esser-von Bieren, Julia, Fedorova, Maria, Friedmann Angeli, José, Friese, Manuel, Fuhrmann, Dominic, Garbowicz, Karolina, García-Sáez, Ana, Gu, Wei, Götz, Magdalena, Hammerich, Linda, Hassannia, Behrouz, Jeridi, Aicha, Jiang, Xuejun, Kagan, Valerian, Kang, Yun, Konrad, David, Kotschi, Stefan, Le Tertre, Marlène, Lei, Peng, Lev, Sima, Liang, Deguang, Linkermann, Andreas, Lohr, Carolin, Lorenz, Svenja, Luedde, Tom, Methner, Axel, Michalke, Bernhard, Milton, Anna, Min, Junxia, Mishima, Eikan, Motohashi, Hozumi, Muckenthaler, Martina, Murakami, Shohei, Müller, Sebastian, Olzmann, James, Pagnussat, Gabriela, Pan, Zijan, Papagiannakopoulos, Thales, Pedrera Puentes, Lohans, Pratt, Derek, Proneth, Bettina, Ramsauer, Lukas, Rodriguez, Raphael, Saito, Yoshiro, Schmidt, Felix, Schmitt, Carina, Schulze, Almut, Schwab, Annemarie, Schwantes, Anna, Soula, Mariluz, Spitzlberger, Benedikt, Stockwell, Brent, Thewes, Leonie, Thorn-Seshold, Oliver, Tonnus, Wulf, Toyokuni, Shinya, Trumpp, Andreas, Vanden Berghe, Tom, Vandenabeele, Peter, Venkataramani, Vivek, Vogel, Felix, von Karstedt, Silvia, Wang, Fudi, Westermann, Frank, Wientjens, Chantal, Wilhelm, Christoph, Wu, Katherine, Wölk, Michele, Yang, Xin, Yu, Fan, Zou, Yilong   +93 more
core   +10 more sources

Ferroptosis: machinery and regulation [PDF]

Autophagy, 2020
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron-containing enzyme lipoxygenase is the main promoter of ferroptosis by
Xin Chen, Jingbo Li, R. Kang, D. Klionsky, D. Tang   +4 more
semanticscholar   +4 more sources

Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies

Signal Transduction and Targeted Therapy
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid peroxides.
Qian Zhou, Yu Meng, Daishi Li, Lei Yao, Jiayuan Le, Yihuang Liu, Yuming Sun, Furong Zeng, Xiang Chen, Guangtong Deng   +9 more
doaj   +2 more sources

Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma [PDF]

, 2017
Recent data have indicated a fundamental role of iron in mediating a non-apoptotic and non-necrotic oxidative form of programmed cell death termed ferroptosis that requires abundant cytosolic free labile iron to promote membrane lipid peroxidation ...
Alessandro Fanzani, Maura Poli
openalex   +3 more sources

FSP1 is a glutathione-independent ferroptosis suppressor [PDF]

Nature, 2019
Sebastian Doll, Florêncio Porto Freitas, Ron Shah, Maceler Aldrovandi, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Thamara Nishida Xavier da Silva, Elena Panzilius, Christina Scheel, André Mourão, Katalin Buday, Mami Sato, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Markus Rehberg, Andrew Flatley, Aloys Schepers, Andreas Kurz, Daniel A. White, Markus Sauer, Michael Sattler, Edward W. Tate, Werner Schmitz, Almut Schulze, Valerie B. O’Donnell, Bettina Proneth, Grzegorz M. Popowicz, Derek A. Pratt, José Pedro Friedmann Angeli, Marcus Conrad   +31 more
openalex   +2 more sources

Recent Advances in Nanotechnology-Based Approaches for Ferroptosis Therapy and Imaging Diagnosis in Pancreatic Cancer [PDF]

Pharmaceutics
Pancreatic cancer is a highly lethal malignant tumor characterized by challenges in early diagnosis and limited therapeutic options, leading to an exceptionally low clinical cure rate.
Xiaoyan Yang, Wangping Luo, Yining Wang, Yongzhong Du, Risheng Yu   +4 more
doaj   +2 more sources