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Ferroptosis in health and disease. [PDF]

Redox Biology
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane ...
Alborzinia, H., Amen, V.S., Ayton, S., Barayeu, U., Bartelt, A., Bayir, H., Bebber, C.M., Berndt, C., Birsoy, K., Brabletz, S., Brabletz, T., Brown, A.R., Bruneau, A., Brüne, B., Bulli, G., Böttcher, J.P., Chen, Q., Conrad, M., DeNicola, G.M., Dick, T.P., Distéfano, A., Dixon, S.J., Engler, J.B., Esser-von Bieren, J., Fedorova, M., Friedmann Angeli, J.P., Friese, M.A., Fuhrmann, D.C., Garbowicz, K., García-Sáez, A.J., Gu, W., Götz, M., Hammerich, L., Hassannia, B., Jeridi, A., Jiang, X., Kagan, V.E., Kang, Y.P., Konrad, D.B., Kotschi, S., Le Tertre, M., Lei, P., Lev, S., Liang, D., Linkermann, A., Lohr, C., Lorenz, S., Luedde, T., Methner, A., Michalke, B., Milton, A.V., Min, J., Mishima, E., Motohashi, H., Muckenthaler, M.U., Murakami, S., Müller, S., Olzmann, J.A., Pagnussat, G., Pan, Z., Papagiannakopoulos, T., Pedrera Puentes, L., Pratt, D.A., Proneth, B., Ramsauer, L., Rodriguez, R., Saito, Y., Schmidt, F., Schmitt, C., Schulze, A., Schwab, A., Schwantes, A., Soula, M., Spitzlberger, B., Stockwell, B.R., Thewes, L., Thorn-Seshold, O., Tonnus, W., Toyokuni, S., Trumpp, A., Vanden Berghe, T., Vandenabeele, P., Venkataramani, V., Vogel, FCE, von Karstedt, S., Wang, F., Westermann, F., Wientjens, C., Wilhelm, C., Wu, K., Wölk, M., Yang, X., Yu, F., Zou, Y.   +93 more
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Ferroptosis [PDF]

Current Biology, 2020
Iron is an essential micronutrient for microorganisms, plants, animals, and humans. However, iron overload can damage the organism through a variety of mechanisms, including the induction of cell death. Ferroptosis is defined as an iron-dependent form of regulated cell death caused by unrestricted lipid peroxidation and subsequent membrane damage ...
Daolin, Tang, Guido, Kroemer
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Lipid Metabolism and Ferroptosis [PDF]

Biology, 2021
Ferroptosis is a type of iron-dependent regulated necrosis induced by lipid peroxidation that occurs in cellular membranes. Among the various lipids, polyunsaturated fatty acids (PUFAs) associated with several phospholipids, such as phosphatidylethanolamine (PE) and phosphatidylcholine (PC), are responsible for ferroptosis-inducing lipid peroxidation ...
Ji-Yoon Lee, Won Kon Kim, Kwang-Hee Bae, Sang Chul Lee, Eun-Woo Lee   +4 more
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Quercetin and Ferroptosis

Life, 2023
Quercetin is a flavonoid present in apples, onions, tea, red wines, and berries, and it has shown different beneficial effects, such as providing cardiovascular protection, possessing anti-inflammatory properties, and demonstrating anticancer activity, among others.
Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera   +1 more
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Characteristics and Biomarkers of Ferroptosis [PDF]

Frontiers in Cell and Developmental Biology, 2021
The induction and consequences of regulated cell death (RCD) are accompanied by changes in gene and protein expression, biochemical pathways, as well as cell morphology and size. Such RCDs have a significant impact on development, tissue homeostasis, and the occurrence and progression of disease.
Xin Chen, Xin Chen, Xin Chen, Paul B. Comish, Daolin Tang, Daolin Tang, Rui Kang   +6 more
openaire   +3 more sources

Mechanisms of ferroptosis [PDF]

Cellular and Molecular Life Sciences, 2016
Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4). This lethal process is defined by the iron-dependent accumulation of lipid reactive oxygen species and depletion of plasma ...
Jennifer Yinuo Cao, Scott J. Dixon
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Implication of ferroptosis in aging [PDF]

Cell Death Discovery, 2021
AbstractLife is indeed continuously going through the irreversible and inevitable process of aging. The rate of aging process depends on various factors and varies individually. These factors include various environmental stimuli including exposure to toxic chemicals, psychological stress whereas suffering with various illnesses specially the chronic ...
Maryam Mazhar, Ahmad Ud Din, Hamid Ali, Guoqiang Yang, Wei Ren, Li Wang, Xiaohui Fan, Sijin Yang   +7 more
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Ferroptosis in life: To be or not to be

Biomedicine & Pharmacotherapy, 2023
Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria and aberrant accumulation of excessive iron as well as loss of the cysteine-glutathione-GPX4 axis.
Ling Xu, Yu’e Liu, Xi Chen, Hua Zhong, Yi Wang   +4 more
openaire   +2 more sources

Predicting prognosis and clinical features of the tumor microenvironment based on ferroptosis score in patients with breast cancer

Scientific Reports, 2022
Ferroptosis genes have recently been reported to be involved in regulating the development of cancer, but their potential role in breast cancer (BRCA) is not fully understood.
Lianli Yin, Yinghua Tang
doaj   +1 more source

A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]

, 2020
The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi, Demuynck, Robin, Efimova, Iuliia, Krysko, Dmitri, Lin, Abraham   +4 more
core   +1 more source