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Ferroptosis in health and disease [PDF]
Redox BiologyFerroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane ...
Carsten Berndt +93 more
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Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma [PDF]
, 2017 Recent data have indicated a fundamental role of iron in mediating a non-apoptotic and non-necrotic oxidative form of programmed cell death termed ferroptosis that requires abundant cytosolic free labile iron to promote membrane lipid peroxidation ...
Alessandro Fanzani, Maura Poli
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Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 [PDF]
, 2017 学位記番号 ...
Ryosuke Shintoku +7 more
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Current Biology, 2020 Iron is an essential micronutrient for microorganisms, plants, animals, and humans. However, iron overload can damage the organism through a variety of mechanisms, including the induction of cell death. Ferroptosis is defined as an iron-dependent form of regulated cell death caused by unrestricted lipid peroxidation and subsequent membrane damage ...
Daolin, Tang, Guido, Kroemer
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Lipid Metabolism and Ferroptosis [PDF]
Biology, 2021 Ferroptosis is a type of iron-dependent regulated necrosis induced by lipid peroxidation that occurs in cellular membranes. Among the various lipids, polyunsaturated fatty acids (PUFAs) associated with several phospholipids, such as phosphatidylethanolamine (PE) and phosphatidylcholine (PC), are responsible for ferroptosis-inducing lipid peroxidation ...
Ji-Yoon Lee +4 more
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Characteristics and Biomarkers of Ferroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2021 The induction and consequences of regulated cell death (RCD) are accompanied by changes in gene and protein expression, biochemical pathways, as well as cell morphology and size. Such RCDs have a significant impact on development, tissue homeostasis, and the occurrence and progression of disease.
Xin Chen +6 more
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Life, 2023 Quercetin is a flavonoid present in apples, onions, tea, red wines, and berries, and it has shown different beneficial effects, such as providing cardiovascular protection, possessing anti-inflammatory properties, and demonstrating anticancer activity, among others.
Alfredo Cruz-Gregorio +1 more
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Mechanisms of ferroptosis [PDF]
Cellular and Molecular Life Sciences, 2016 Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4). This lethal process is defined by the iron-dependent accumulation of lipid reactive oxygen species and depletion of plasma ...
Jennifer Yinuo Cao, Scott J. Dixon
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Implication of ferroptosis in aging [PDF]
Cell Death Discovery, 2021 AbstractLife is indeed continuously going through the irreversible and inevitable process of aging. The rate of aging process depends on various factors and varies individually. These factors include various environmental stimuli including exposure to toxic chemicals, psychological stress whereas suffering with various illnesses specially the chronic ...
Maryam Mazhar +7 more
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Ferroptosis in life: To be or not to be
Biomedicine & Pharmacotherapy, 2023 Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria and aberrant accumulation of excessive iron as well as loss of the cysteine-glutathione-GPX4 axis.
Ling Xu +4 more
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