Results 11 to 20 of about 147,915 (338)

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. [PDF]

Nature, 2019
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
A Arroyo, Bingqi Tong, BR Stockwell, Breanna Ford, Daniel K. Nomura, DL Tribble, DW Morgens, I Ingold, James A. Olzmann, JL Macdonald, Joseph M. Hendricks, K Bersuker, K Shimada, Kirill Bersuker, KR Marshall, L Magtanong, Leslie Magtanong, M Hayano, M Wu, Melissa A. Roberts, MG Rees, Michael C. Bassik, MJ Hangauer, Peter H. Tang, PH Tang, R Stocker, Roberto Zoncu, Scott J. Dixon, SJ Dixon, SJ Dixon, SJ Dixon, T Inoue, T Inoue, T Takahashi, TB Nguyen, Thomas J. Maimone, VS Viswanathan, WS Yang, WS Yang, X Sun, Y Ohiro, Y Zhang, Y Zou, Zhipeng Li   +43 more
core   +2 more sources

The diversified role of mitochondria in ferroptosis in cancer

Cell Death and Disease, 2023
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012.
Yu’e Liu, Shiping Lu, Lei-lei Wu, Liang Yang, Lixue Yang, Jinghan Wang   +5 more
doaj   +2 more sources

ZK53 enhances tumor cell susceptibility to ferroptosis via ClpP-mediated mitochondrial dysfunction [PDF]

Frontiers in Oncology
Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. This process has garnered increasing attention due to its potential as a promising therapeutic strategy for cancer.
Songjun Dai, Tingting Zhang, Xiaoyan Dai, Keke Zheng, Hong Qian, Zhou Tong, Qiang Zhang   +6 more
doaj   +2 more sources

Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation

Cell Death Discovery
Ferroptosis represents a distinct form of programmed cell death triggered by excessive iron accumulation and lipid peroxidation-induced damage. This mode of cell death differentiates from classical programmed cell death in terms of morphology and ...
Xin Jin, Jiuren Tang, Xiangyu Qiu, Xiaoya Nie, Shengming Ou, Geyan Wu, Rongxin Zhang, Jinrong Zhu   +7 more
doaj   +2 more sources

HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1

Cell Reports, 2023
Summary: Solid tumors have developed robust ferroptosis resistance. The mechanism underlying ferroptosis resistance regulation in solid tumors, however, remains elusive.
Zhou Yang, Wei Su, Xiyi Wei, Shuang Qu, Dan Zhao, Jingwan Zhou, Yunjun Wang, Qing Guan, Chao Qin, Jun Xiang, Ke Zen, Bing Yao   +11 more
doaj   +1 more source

Exosomes and ferroptosis: roles in tumour regulation and new cancer therapies [PDF]

PeerJ, 2022
Research on the biological role of exosomes is rapidly developing, and recent evidence suggests that exosomal effects involve ferroptosis. Exosomes derived from different tissues inhibit ferroptosis, which increases tumour cell chemoresistance. Therefore,
Yixin Shi, Bingrun Qiu, Linyang Huang, Jie Lin, Yiling Li, Yiting Ze, Chenglong Huang, Yang Yao   +7 more
doaj   +2 more sources

Oxidative stress as a nexus: Integrating mitophagy and ferroptosis in endometrial carcinogenesis (Review). [PDF]

Oncol Lett
Yu Q, Ren L, Ren F, Li F.
europepmc   +3 more sources

Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors

Frontiers in Oncology, 2023
The brain tumor is a kind of malignant tumor with brutal treatment, high recurrence rate, and poor prognosis, and the incidence and death rate is increasing yearly.
Yansheng Yao, Peng Ji, Hao Chen, Jianwen Ge, Yajing Xu, Peng Wang, Li Xu, Zhirong Yan   +7 more
doaj   +1 more source

Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease

Frontiers in Pharmacology, 2023
Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various diseases, particularly tumors, organ injury, and degenerative pathologies.
Fei Li, Pei-Feng Li, Xiao-Dan Hao
doaj   +1 more source

Induction and application of ferroptosis in cancer therapy

Cancer Cell International, 2022
At present, more than one cell death pathways have been found, one of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid peroxidation-driven regulated cell death pathway.
Qing Nie, Yue Hu, Xiao Yu, Xiao Li, Xuedong Fang   +4 more
doaj   +1 more source