Results 21 to 30 of about 115,871 (339)
Targeting ferroptosis in osteosarcoma
Journal of Bone Oncology, 2021 Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid reactive oxygen species (ROS), is closely associated with a variety of cancers.
Benzheng Zhang +4 more
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A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]
, 2020 The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi +4 more
core +1 more source
Iron Metabolism in Ferroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly ...
Chunhua Yu +5 more
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Cell, 2020 Ferroptosis is a regulated form of cell death that occurs when phospholipids with polyunsaturated fatty acyl tails are oxidized in an iron-dependent manner. Research in recent years has uncovered complex cellular networks that induce and suppress lethal lipid peroxidation.
Hadian, K., Stockwell, B.R.
openaire +3 more sources
Ferroptosis and Liver Fibrosis [PDF]
International Journal of Medical Sciences, 2021 Ferroptosis is an iron-dependent form of regulated cell death, which is characterized by a large amount of lipid peroxide accumulation and the imbalance of redox state in cells. Ferroptosis is usually accompanied with the dysfunction of lipid repair enzyme (glutathione peroxidase 4, GPX4), large masses of iron accumulation and lipid peroxidation of ...
Qiang Xia, Yi Luo, Qi Pan, Kang He
openaire +2 more sources
Ferroptosis in Neurological Diseases [PDF]
Frontiers in Cellular Neuroscience, 2020 Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is crucially involved in neurological diseases, including neurodegeneration, stroke and neurotrauma.
Jia-Xin Ren +5 more
openaire +4 more sources
Opportunities and challenges related to ferroptosis in glioma and neuroblastoma
Frontiers in Oncology, 2023 A newly identified form of cell death known as ferroptosis is characterized by the peroxidation of lipids in response to iron. Rapid progress in research on ferroptosis in glioma and neuroblastoma has promoted the exploitation of ferroptosis in related ...
Huizhong Chi +13 more
doaj +1 more source
NFE2L1-mediated proteasome function protects from ferroptosis
Molecular Metabolism, 2022 Objective: Ferroptosis continues to emerge as a novel modality of cell death with important therapeutic implications for a variety of diseases, most notably cancer and degenerative diseases.
Stefan Kotschi +6 more
doaj +1 more source
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]
, 2017 Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E +11 more
core +1 more source
The diversified role of mitochondria in ferroptosis in cancer
Cell Death and Disease, 2023 Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012.
Yu’e Liu +5 more
doaj +1 more source