Results 21 to 30 of about 109,999 (379)
Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 [PDF]
, 2017 学位記番号 ...
Ryosuke Shintoku +7 more
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Genomic analysis uncovers prognostic and immunogenic characteristics of ferroptosis for clear cell renal cell carcinoma [PDF]
Molecular Therapy: Nucleic Acids, 2021 In this study, the characteristic patterns of ferroptosis in clear cell renal cell carcinoma (ccRCC) were systematically investigated with the interactions between ferroptosis and the tumor microenvironment (TME).
Dan Bai +6 more
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Current Biology, 2020 Iron is an essential micronutrient for microorganisms, plants, animals, and humans. However, iron overload can damage the organism through a variety of mechanisms, including the induction of cell death. Ferroptosis is defined as an iron-dependent form of regulated cell death caused by unrestricted lipid peroxidation and subsequent membrane damage ...
Daolin, Tang, Guido, Kroemer
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Lipid Metabolism and Ferroptosis [PDF]
Biology, 2021 Ferroptosis is a type of iron-dependent regulated necrosis induced by lipid peroxidation that occurs in cellular membranes. Among the various lipids, polyunsaturated fatty acids (PUFAs) associated with several phospholipids, such as phosphatidylethanolamine (PE) and phosphatidylcholine (PC), are responsible for ferroptosis-inducing lipid peroxidation ...
Ji-Yoon Lee +4 more
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Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease
Frontiers in Pharmacology, 2023 Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various diseases, particularly tumors, organ injury, and degenerative pathologies.
Fei Li, Pei-Feng Li, Xiao-Dan Hao
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Characteristics and Biomarkers of Ferroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2021 The induction and consequences of regulated cell death (RCD) are accompanied by changes in gene and protein expression, biochemical pathways, as well as cell morphology and size. Such RCDs have a significant impact on development, tissue homeostasis, and the occurrence and progression of disease.
Xin Chen +6 more
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Life, 2023 Quercetin is a flavonoid present in apples, onions, tea, red wines, and berries, and it has shown different beneficial effects, such as providing cardiovascular protection, possessing anti-inflammatory properties, and demonstrating anticancer activity, among others.
Alfredo Cruz-Gregorio +1 more
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Exosomes and ferroptosis: roles in tumour regulation and new cancer therapies [PDF]
PeerJ, 2022 Research on the biological role of exosomes is rapidly developing, and recent evidence suggests that exosomal effects involve ferroptosis. Exosomes derived from different tissues inhibit ferroptosis, which increases tumour cell chemoresistance. Therefore,
Yixin Shi +7 more
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Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors
Frontiers in Oncology, 2023 The brain tumor is a kind of malignant tumor with brutal treatment, high recurrence rate, and poor prognosis, and the incidence and death rate is increasing yearly.
Yansheng Yao +7 more
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Mechanisms of ferroptosis [PDF]
Cellular and Molecular Life Sciences, 2016 Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4). This lethal process is defined by the iron-dependent accumulation of lipid reactive oxygen species and depletion of plasma ...
Jennifer Yinuo Cao, Scott J. Dixon
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