Results 21 to 30 of about 147,915 (338)
Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries
Antioxidants, 2023 Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases.
Wentao Duan +11 more
doaj +1 more source
A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]
, 2020 The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi +4 more
core +1 more source
Cross Talk Between Ferroptosis and Cerebral Ischemia
Frontiers in Neuroscience, 2020 Recently, ferroptosis has been revealed as a new form of regulated cell death. Distinct from apoptosis and necrosis, ferroptosis is evoked by iron-dependent lipid peroxidation.
Xu She, Bin Lan, Haomei Tian, Biao Tang
doaj +1 more source
Role of ferroptosis on tumor progression and immunotherapy
Cell Death Discovery, 2022 Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation consequent promotion of cell death. Cancer cell exhibits ability to evade ferroptosis by activation of antioxidant signaling pathways such as SLC7A11/GPX4 axis ...
Deting Gong +4 more
doaj +1 more source
Ferroptosis: past, present and future
Cell Death and Disease, 2020 Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent ...
Jie Li +7 more
semanticscholar +1 more source
The Mechanism of Ferroptosis and Applications in Tumor Treatment
Frontiers in Pharmacology, 2020 Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of glutathione peroxidase 4 (GPX4) is characteristic of the ...
Xinyue Lin +4 more
doaj +1 more source
Ferroptosis: molecular mechanisms and health implications
Cell Research, 2020 Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been mounting interest in the process and function of ferroptosis.
D. Tang, Xin Chen, R. Kang, G. Kroemer
semanticscholar +1 more source
Opportunities and challenges related to ferroptosis in glioma and neuroblastoma
Frontiers in Oncology, 2023 A newly identified form of cell death known as ferroptosis is characterized by the peroxidation of lipids in response to iron. Rapid progress in research on ferroptosis in glioma and neuroblastoma has promoted the exploitation of ferroptosis in related ...
Huizhong Chi +13 more
doaj +1 more source
Autophagy mediates an amplification loop during ferroptosis
Cell Death and Disease, 2023 Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is ...
Seunghee Lee +5 more
doaj +1 more source
NFE2L1-mediated proteasome function protects from ferroptosis
Molecular Metabolism, 2022 Objective: Ferroptosis continues to emerge as a novel modality of cell death with important therapeutic implications for a variety of diseases, most notably cancer and degenerative diseases.
Stefan Kotschi +6 more
doaj +1 more source