Results 1 to 10 of about 826,759 (374)

Studies on the Hemoglobin of Cooley's Anemia and Cooley's Trait [PDF]

, 1952
The diseases sickle cell anemia and Cooley's anemia (also known as thalassemia or Mediterranean anemia) have associated with them "minor" or "trait" forms of the disease in which the symptomatology is minimal, and the abnormalities in the red cells are ...
Rich, Alexander
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Patients with sickle cell disease taking hydroxyurea in the Hemocentro Regional de Montes Claros

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: The development of therapies for sickle cell disease has received special attention, particularly those that reduce the polymerization of hemoglobin S.
Fernanda Kelle de Souza Santos, Caroline Nogueira Maia   +1 more
doaj   +1 more source

Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases. [PDF]

, 2016
We examined the efficiency, specificity, and mutational signatures of zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 systems designed to
Bjurström, Carmen F, Cooper, Aaron, Hollis, Roger P, Kaufman, Michael, Kohn, Donald B, Kuo, Caroline, Lai, Stephen, Lill, Georgia R, Mojadidi, Michelle, Phillips, John, Urbinati, Fabrizia, Wang, Xiaoyan   +11 more
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Fetal hemoglobin silencing in humans

Blood, 2006
AbstractInterruption of the normal fetal-to-adult transition of hemoglobin expression should largely ameliorate sickle cell and beta-thalassemia syndromes. Achievement of this clinical goal requires a robust understanding of gamma-globin gene and protein silencing during human development.
Naomi L. C. Luban, Naomi L. C. Luban, Nicole M. Gantt, Nicole M. Gantt, Joseph D. Schwartz, Joseph D. Schwartz, Natarajan V. Bhanu, Natarajan V. Bhanu, John W. Moroney, John W. Moroney, Jeffery L. Miller, Jeffery L. Miller, Christopher H. Reed, Christopher H. Reed, Patricia A. Oneal, Patricia A. Oneal, Alan N. Schechter, Alan N. Schechter, Y. Terry Lee, Y. Terry Lee   +19 more
openaire   +4 more sources

Abnormal hemoglobins in Malta : the significance of two fetal and an adult variant [PDF]

, 1972
The study of human hemoglobin variants has a special place in hemoglobin research. The discovery of hemoglobin F (Malta) by Cauchi et al. (1969) and the high incidence of this hemoglobin in Maltese newborns gave us the opportunity to initiate a ...
Bannister, William H., Grech, J.L., Huisman, Titus Hendrik Jan, Schroeder, W.A.   +3 more
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Joint analysis of functional genomic data and genome-wide association studies of 18 human traits

, 2014
Annotations of gene structures and regulatory elements can inform genome-wide association studies (GWAS). However, choosing the relevant annotations for interpreting an association study of a given trait remains challenging.
Pickrell, Joseph K.
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Disorders of the synthesis of human fetal hemoglobin [PDF]

IUBMB Life, 2008
AbstractFetal hemoglobin (HbF), the predominant hemoglobin in the fetus, is a mixture of two molecular species (α2Gγ2 and α2Aγ2) that differ only at position 136 reflecting the products of two nonallelic γ‐globin genes. At the time of birth, HbF accounts for ∼70% of the total Hb.
MANCA, Laura, MASALA, Bruno Lucio
openaire   +4 more sources

Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population [PDF]

, 2013
Haptoglobin's (Hp) antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular disease risk and treatment response to antioxidant vitamins in some non-pregnant populations.
Alan M. Peaceman, Anthony Sciscione, AP Levy, AP Levy, AP Levy, AR Rumbold, Brian M. Mercer, Catherine Y. Spong, Cees Oudejans, D Altman, D Beazley, DD Waters, DM Jensen, EM Wendland, George Saade, H Goldenstein, HK Ury, HT Depypere, J Villar, JA Simon, JC Hauth, JM Roberts, JM Roberts, JNK Rao, John M. Thorp, Jorge E. Tolosa, Kenneth J. Leveno, L Mosca, L Myatt, L Poston, LC Chappell, LC Chappell, LE Cahill, Leslie Myatt, M Knuist, Margaret Harper, Marshall W. Carpenter, MB Landon, MC Cid, MR Langlois, MT Raijmakers, Paula L. McGee, Philip Samuels, R Asleh, RE Gaensslen, RN Sammour, Robin E. Gandley, S Blum, S Blum, S Blum, S Gupta, S Yusuf, SE Maynard, Susan M. Ramin, Tracey L. Weissgerber, U Milman, Yoram Sorokin, YW Park   +57 more
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Índice cárdio-femoral para avaliação da anemia de fetos de gestantes isoimunizadas Cardiofemoral index for the evaluation of fetal anemia in isoimmunized pregnancies

Revista Brasileira de Ginecologia e Obstetrícia, 2005
OBJETIVO: estabelecer novo marcador não invasivo na detecção da anemia fetal, em gestantes isoimunizadas por antígenos eritrocitários. MÉTODOS: em estudo transversal o índice ecográfico obtido pela razão entre a medida ecográfica do diâmetro ...
Antônio Carlos Vieira Cabral, Thales Bittencourt de Barcelos, Isabela Gomes Melo Apocalipse, Henrique Vitor Leite, Zilma Silveira Nogueira Reis   +4 more
doaj   +1 more source

Variants of hemoglobin F and observations on hemoglobin F (Malta) [PDF]

, 1970
The major hemoglobin component found in the blood of humans at birth is fetal hemoglobin, hemoglobin F. In common with most other human hemoglobins it has a tetrameric structure, each molecule being made up of two different pairs of polypeptide chains ...
Brown, I.R.F., Grech, J.L.
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