Results 1 to 10 of about 51,897 (312)
Transcriptional regulators of fetal hemoglobin [PDF]
Hematology, Transfusion and Cell TherapySickle cell anemia is a hereditary disease caused by sickle-shaped red blood cells that can lead to vaso-occlusive crises. Treatment options are currently limited, highlighting the need to develop new clinical approaches.
Gabriela Pereira dos Santos +5 more
doaj +4 more sources
Hereditary persistence of fetal hemoglobin
Asian Journal of Transfusion Science, 2020 Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.
Dharmesh Chandra Sharma +5 more
doaj +3 more sources
A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds [PDF]
HemaSphereReactivation of fetal hemoglobin expression alleviates the symptoms associated with β‐globinopathies, severe hereditary diseases with significant global health implications due to their high morbidity and mortality rates.
Thijs C. J. Verheul +15 more
doaj +2 more sources
Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in β0-thalassemia/HbE erythroid cells. [PDF]
PLoS ONE, 2023 Imbalanced globin chain output contributes to thalassemia pathophysiology. Hence, induction of fetal hemoglobin in β-thalassemia and other β-hemoglobinopathies are of continuing interest for therapeutic approaches.
Sukanya Chumchuen +4 more
doaj +2 more sources
The Clinical Approach toward Hereditary Persistence of Fetal Hemoglobin: A Case Report
Iranian Journal of Allergy, Asthma and Immunology, 2022 Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin.
Afshin Ghaderi +3 more
doaj +1 more source
Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. [PDF]
PLoS ONE, 2013 Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease,
Nancy S Green +12 more
doaj +1 more source
Sickle cell disease and fetal hemoglobin
Saudi Journal of Medicine and Medical Sciences, 2018 Alicia Rivera
doaj +3 more sources
Fetomaternal hemorrhage - case report
Journal of Education, Health and Sport, 2022 Maternal fetal leakage (FMH) is a well-known cause of fetal anemia. We define it as the transition of the fetal erythrocytes into the maternal circulation. Its severity is determined by measuring the level of fetal hemoglobin in the mother's blood using
Jakub Gruszka +3 more
doaj +1 more source
Keeping fetal hemoglobin in the loop [PDF]
Cell Cycle, 2014 Sickle cell disease (SCD) is caused by a point mutation in the adult type β-globin gene. The faulty β-globin chain triggers hemoglobin polymerization, promoting red blood cell sickling. Altered red blood cell shape causes occlusion of small blood vessels, leading to multi-organ damage and limiting life expectancy to 40–50 y of age.
Gerd A. Blobel, Jeremy D. Grevet
openaire +3 more sources
Perspective: A novel prognostic for sickle cell disease
Saudi Journal of Medicine and Medical Sciences, 2018 Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski +3 more
doaj +1 more source