Results 11 to 20 of about 819,369 (331)
Pharmaceuticals, 2022 A significant amount of attention has recently been devoted to the mechanisms involved in hemoglobin (Hb) switching, as it has previously been established that the induction of fetal hemoglobin (HbF) production in significant amounts can reduce the ...
R. Bou-Fakhredin +4 more
semanticscholar +1 more source
The Clinical Approach toward Hereditary Persistence of Fetal Hemoglobin: A Case Report
Iranian Journal of Allergy, Asthma and Immunology, 2022 Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin.
Afshin Ghaderi +3 more
doaj +1 more source
A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin
bioRxiv, 2022 Proximity-based strategies to degrade proteins have enormous therapeutic potential in medicine, but the technologies are limited to proteins for which small molecule ligands exist.
Fangfang Shen +8 more
semanticscholar +1 more source
Nature Genetics, 2021 Hereditary persistence of fetal hemoglobin (HPFH) ameliorates β-hemoglobinopathies by inhibiting the developmental switch from γ-globin (HBG1/HBG2) to β-globin (HBB) gene expression.
Phillip A. Doerfler +9 more
semanticscholar +1 more source
Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch [PDF]
Cell, 2018 Nan Liu +15 more
openalex +2 more sources
Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. [PDF]
PLoS ONE, 2013 Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease,
Nancy S Green +12 more
doaj +1 more source
Fetal Hemoglobin in Sickle Cell Anemia.
Blood, 2020 Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course and offer prospects for curative therapy of sickle cell disease. This review focuses on: 1.
M. Steinberg
semanticscholar +1 more source
Perspective: A novel prognostic for sickle cell disease
Saudi Journal of Medicine and Medical Sciences, 2018 Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski +3 more
doaj +1 more source
Fetomaternal hemorrhage - case report
Journal of Education, Health and Sport, 2022 Maternal fetal leakage (FMH) is a well-known cause of fetal anemia. We define it as the transition of the fetal erythrocytes into the maternal circulation. Its severity is determined by measuring the level of fetal hemoglobin in the mother's blood using
Jakub Gruszka +3 more
doaj +1 more source
Sickle cell disease and fetal hemoglobin
Saudi Journal of Medicine and Medical Sciences, 2018 Alicia Rivera
doaj +3 more sources