Results 11 to 20 of about 51,897 (312)
Haematologica, 2019 Hematologic responses to hypomethylating agents are often delayed in patients with myelodysplastic syndrome or acute myeloid leukemia. Fetal hemoglobin is a potential novel bio-marker of response: recently, we demonstrated that a high fetal hemoglobin ...
Julia Stomper +10 more
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Breaking Free from Your Fetal Chains: A Case-Based Review of the Literature on Gamma Chain Variant Hemoglobinopathies [PDF]
Neonatal Medicine, 2023 Methemoglobinemia is a dyshemoglobinemia characterized by cyanosis and reduced oxygen saturation with increased methemoglobin values. The etiology may be congenital or acquired, with the latter being more common.
Pearl Mary Varughese +3 more
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Hydroxyurea ameliorates mouse hypoxia through inducing embryonic hemoglobin
陆军军医大学学报, 2023 Objective To investigate the ameliorative effect and mechanism of hydroxyurea (HU) on hypoxia mice in a closed environment. Methods Sixty male C57BL/6J mice (6~8 weeks old, weighing 18~22 g) were randomly divided into normoxia control group (NC, n=10 ...
ZHOU Xiaoying +4 more
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Effect of hydroxyurea on G gamma chain fetal hemoglobin synthesis by sickle-cell disease patients
Brazilian Journal of Medical and Biological Research, 2003 Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis and consequently decrease the severity of pain episodes.
S.M. Teixeira +2 more
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Deep Learning Fetal Ultrasound Video Model Match Human Observers in Biometric Measurements [PDF]
Physics in Medicine & Biology, 67(4), 045013 (2022), 2022 Objective. This work investigates the use of deep convolutional neural networks (CNN) to automatically perform measurements of fetal body parts, including head circumference, biparietal diameter, abdominal circumference and femur length, and to estimate gestational age and fetal weight using fetal ultrasound videos. Approach. We developed a novel multi-
arxiv +1 more source
Haematologica, 2016 Increased fetal hemoglobin levels lessen the severity of symptoms and increase the lifespan of patients with sickle cell disease. Hydroxyurea, the only drug currently approved for the treatment of sickle cell disease, is not effective in a large ...
Angela Rivers +9 more
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eLife, 2022 Naturally occurring point mutations in the HBG promoter switch hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary persistence of fetal hemoglobin (HPFH) and ameliorate the clinical severity.
Nithin Sam Ravi +24 more
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Analytical theory of oxygen transfer in the human placenta [PDF]
J. Theor. Biol. 368 (2015), 133-44, 2014 We propose an analytical approach to solving the diffusion-convection equations governing oxygen transport in the human placenta. We show that only two geometrical characteristics of a placental cross-section, villi density and the effective villi radius, are needed to predict fetal oxygen uptake.
arxiv +1 more source
Anemia, 2013 Objectives. To compare current criteria for severe fetal anemia diagnosis. Methodology. A cohort study analyzed 105 alloimmunized fetuses that underwent cordocentesis due to risk of anemia.
Zilma Silveira Nogueira Reis +5 more
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Molecular Dynamics Simulations Indicate that Deoxyhemoglobin, Oxyhemoglobin, Carboxyhemoglobin, and Glycated Hemoglobin under Compression and Shear Exhibit an Anisotropic Mechanical Behavior [PDF]
Journal of Biomolecular Structure and Dynamics, 2017, 2017 We developed a new mechanical model for determining the compression and shear mechanical behavior of four different hemoglobin structures. Previous studies on hemoglobin structures have focused primarily on overall mechanical behavior; however, this study investigates the mechanical behavior of hemoglobin, a major constituent of red blood cells (RBCs),
arxiv +1 more source