Results 11 to 20 of about 832,435 (375)
The Clinical Approach toward Hereditary Persistence of Fetal Hemoglobin: A Case Report
Iranian Journal of Allergy, Asthma and Immunology, 2022 Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin.
Afshin Ghaderi +3 more
doaj +1 more source
Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. [PDF]
PLoS ONE, 2013 Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease,
Nancy S Green +12 more
doaj +1 more source
Sickle cell disease and fetal hemoglobin
Saudi Journal of Medicine and Medical Sciences, 2018 Alicia Rivera
doaj +3 more sources
Fetal Hemoglobin in Sickle Cell Anemia.
Blood, 2020 Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course and offer prospects for curative therapy of sickle cell disease. This review focuses on: 1.
M. Steinberg
semanticscholar +1 more source
Science Advances, 2020 Editing the fetal γ-globin promoters in hematopoietic stem cells from sickle cell disease patients induces therapeutic γ-globin levels. Sickle cell disease (SCD) is caused by a single amino acid change in the adult hemoglobin (Hb) β chain that causes Hb ...
Leslie Weber +18 more
semanticscholar +1 more source
Fetomaternal hemorrhage - case report
Journal of Education, Health and Sport, 2022 Maternal fetal leakage (FMH) is a well-known cause of fetal anemia. We define it as the transition of the fetal erythrocytes into the maternal circulation. Its severity is determined by measuring the level of fetal hemoglobin in the mother's blood using
Jakub Gruszka +3 more
doaj +1 more source
ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression
bioRxiv, 2020 Metazoan transcription factors typically regulate large numbers of genes. Here we identify via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA binding protein that in human erythroid cells directly and measurably activates only one gene, the NuRD ...
Xianjiang Lan +19 more
semanticscholar +1 more source
Keeping fetal hemoglobin in the loop [PDF]
Cell Cycle, 2014 Sickle cell disease (SCD) is caused by a point mutation in the adult type β-globin gene. The faulty β-globin chain triggers hemoglobin polymerization, promoting red blood cell sickling. Altered red blood cell shape causes occlusion of small blood vessels, leading to multi-organ damage and limiting life expectancy to 40–50 y of age.
Gerd A. Blobel, Jeremy D. Grevet
openaire +3 more sources
Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes
Journal of Clinical Medicine, 2020 Fetal hemoglobin (HbF) usually consists of 4 to 10% of total hemoglobin in adults of African descent with sickle cell anemia. Rarely, their HbF levels reach more than 30%.
M. Steinberg
semanticscholar +1 more source
Perspective: A novel prognostic for sickle cell disease
Saudi Journal of Medicine and Medical Sciences, 2018 Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski +3 more
doaj +1 more source