Results 31 to 40 of about 819,369 (331)

Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34+ HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin

Scientific Reports, 2020
β-hemoglobinopathies are caused by abnormal or absent production of hemoglobin in the blood due to mutations in the β-globin gene (HBB). Imbalanced expression of adult hemoglobin (HbA) induces strong anemia in patients suffering from the disease. However,
Andrés Lamsfus-Calle, A. Daniel-Moreno, J. Antony, T. Epting, Lukas Heumos, Praveen Baskaran, Jakob Admard, Nicolas Casadei, Ngadhnjim Latifi, Darina M. Siegmund, M. Kormann, R. Handgretinger, Markus Mezger   +12 more
semanticscholar   +1 more source

Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes: A Comparative Analysis of the Current Reference Values

Anemia, 2013
Objectives. To compare current criteria for severe fetal anemia diagnosis. Methodology. A cohort study analyzed 105 alloimmunized fetuses that underwent cordocentesis due to risk of anemia.
Zilma Silveira Nogueira Reis, Gabriel Costa Osanan, Tiago Lanfernini Ricardo Coelho, Cezar Alencar De Lima Rezende, Henrique Vitor Leite, Antônio Carlos Vieira Cabral   +5 more
doaj   +1 more source

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease

Haematologica, 2020
While ineffective erythropoiesis has long been recognized as a key contributor to anemia in thalassemia, its role in anemia of sickle cell disease (SCD) has not been critically explored.
Sara El Hoss, S. Cochet, A. Godard, Hongxia Yan, M. Dussiot, G. Frati, B. Boutonnat-Faucher, Sandrine Laurance, O. Renaud, L. Joseph, A. Miccio, V. Brousse, N. Mohandas, W. El Nemer   +13 more
semanticscholar   +1 more source

Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline

Revista Brasileira de Hematologia e Hemoterapia, 2012
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers.
Darcielle Bruna Dias Elias, Lilianne Brito da Silva Rocha, Maritza Barbosa Cavalcante, Alano Martins Pedrosa, Izabel Cristina Bandeira Justino, Romélia Pinheiro Gonçalves   +5 more
doaj   +1 more source

Genome editing strategies for fetal hemoglobin induction in beta-hemoglobinopathies.

Human Molecular Genetics, 2020
Genome editing to correct a defective β-globin gene or induce fetal globin (HbF) for patients with beta-hemoglobinopathies has the potential to be a curative strategy available to all.
Selami Demirci, Alexis Leonard, J. Tisdale   +2 more
semanticscholar   +1 more source

Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies. [PDF]

Int J Mol Sci
Stephanou C, Menzel S, Philipsen S, Kountouris P, International Hemoglobinopathy Research Network (INHERENT).   +4 more
europepmc   +3 more sources

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.

Blood Advances, 2019
Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic repeats/Cas9-mediated disruption of DNA regulatory elements that repress γ-globin gene (HBG1 and HBG2) expression is a promising therapeutic strategy for sickle ...
J. Métais, Phillip A. Doerfler, Thiyagaraj Mayuranathan, Daniel E. Bauer, S. Fowler, M. Hsieh, Varun Katta, Sagar Keriwala, C. Lazzarotto, Kevin Luk, Michael D. Neel, S. Scott Perry, Samuel T. Peters, Shaina N. Porter, Byoung Y. Ryu, Akshay Sharma, Devlin N. Shea, J. Tisdale, N. Uchida, S. Wolfe, Kaitly J. Woodard, Yuxuan Wu, Yu Yao, Jing Zeng, S. Pruett-Miller, S. Tsai, Mitchell J. Weiss   +26 more
semanticscholar   +1 more source

TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction

Molecular Therapy: Methods & Clinical Development, 2019
Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clinically
Christopher T. Lux, Sowmya Pattabhi, Mason Berger, Cynthia Nourigat, David A. Flowers, Olivier Negre, Olivier Humbert, Julia G. Yang, Calvin Lee, Kyle Jacoby, Irwin Bernstein, Hans-Peter Kiem, Andrew Scharenberg, David J. Rawlings   +13 more
doaj   +1 more source

STUDY OF FETAL HEMOGLOBIN WITH GESTATIONAL AGE, BIRTH WEIGHT AND RETINOPATHY OF PREMATURITY IN PRETERM INFANTS

IJRETINA (International Journal of Retina), 2023
Introduction: The objective of this study was to find an association of fetal hemoglobin (HbF) with gestational age, birth weight and retinopathy of prematurity (ROP) in preterm infants. Methods: Observational prospective study. We included a total of
Nishi Prasad, Aditi Dubey, Kavita Kumar, Jyotsna Shrivastava   +3 more
doaj   +1 more source

Association of HMIP1 C-893A polymorphism and disease severity in patients with sickle cell anemia

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Sickle cell anemia (SCA) is a Mendelian disorder with a heterogeneous clinical course. The reasons for this phenotypic diversity are not entirely established, but it is known that high fetal hemoglobin levels lead to a milder course of the ...
Diego A. Pereira-Martins, Igor F. Domingos, Edis Belini-Junior, Juan L. Coelho-Silva, Isabel Weinhäuser, Aderson S. Araújo, Clarisse L. Lobo, Claudia R. Bonini-Domingos, Marcos A. Bezerra, Antonio R. Lucena-Araujo   +9 more
doaj   +1 more source