Results 31 to 40 of about 51,897 (312)
What influences Hb fetal production in adulthood?
Revista Brasileira de Hematologia e Hemoterapia, 2011 Human hemoglobin genes are located in α and β globin gene clusters in chromosomes 16 and 11, respectively. Different types of hemoglobin are synthesized according to the stage of development with fetal hemoglobin (α2γ2) (Hb F) being ...
Gisele Cristine de Souza Carrocini +2 more
doaj +1 more source
Oxidative stress in preeclampsia and the role of free fetal hemoglobin
Frontiers in Physiology, 2015 Preeclampsia is a leading cause of pregnancy complications and affects 3–7 % of pregnant women. This review summarizes the current knowledge of a new potential etiology of the disease, with a special focus on hemoglobin-induced oxidative stress ...
Stefan Rocco Hansson +2 more
doaj +1 more source
A new target for fetal hemoglobin reactivation
Haematologica, 2019 Angela Rivers +2 more
doaj +4 more sources
BMC Pregnancy and Childbirth, 2018 Background Complete blood count is one of the routinely advised blood investigation during pregnancy. It is also utilized as a diagnostic tool for neonatal anemia, sepsis and determining hemostatic status of the newborn.
Sameer Timilsina +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Diabetes/Metabolism Research and Reviews, Volume 39, Issue 1, January 2023., 2023 Abstract Background Women with type 1 diabetes (T1D) are more susceptible than men to cardiovascular disease (CVD). Signs of increased risk may already appear among adolescent girls. Objectives We explored the contribution of body composition to the development of CVD risk factors among youth with T1D.
Avivit Brener +10 more
wiley +1 more source
Fetal hemoglobin silencing in humans
Blood, 2006 AbstractInterruption of the normal fetal-to-adult transition of hemoglobin expression should largely ameliorate sickle cell and beta-thalassemia syndromes. Achievement of this clinical goal requires a robust understanding of gamma-globin gene and protein silencing during human development.
Naomi L. C. Luban +19 more
openaire +4 more sources
Fetal cardiovascular decompensation during labor predicted from the individual heart rate: a prospective study in fetal sheep near term and the impact of low sampling rate [PDF]
Front. Pediatr. 2021, 2019 We present a novel computerized fetal heart rate intrapartum algorithm for early and individualized prediction of fetal cardiovascular decompensation, a key event in the causal chain leading to brain injury. This real-time machine learning algorithm performs well on noisy fetal heart rate data and requires ~2 hours to train on the individual fetal ...
arxiv +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
eLife, 2021 Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named hereditary persistence of fetal ...
Pamela Himadewi +10 more
doaj +1 more source